Cyclophosphamide
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Cyclophosphamide
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CAS No:
50-18-0
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Formula:
C7H15Cl2N2O2P
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Chemical Name:
Cyclophosphamide
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Synonyms:
2H-1,3,2-Oxazaphosphorin-2-amine,N,N-bis(2-chloroethyl)tetrahydro-,2-oxide;2H-1,3,2-Oxazaphosphorine,2-[bis(2-chloroethyl)amino]tetrahydro-,2-oxide;B 518;NSC 26271;Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester;N,N-Bis(2-chloroethyl)-N′,O-propylenephosphoric acid ester diamide;N,N-Bis(β-chloroethyl)-N′,O-trimethylenephosphoric acid ester diamide;Cyclophosphamid;Cyclophosphamide;Cyclophosphan;Cyclophosphane;Cytoxan;Endoxan;Genoxal;Clafen;Cytophosphan;Claphene;Asta B 518;2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide;Procytox;Sendoxan;(±)-Cyclophosphamide;(RS)-Cyclophosphamide;Cyclostin;Cycloblastin;Neosar;Neosar (antineoplastic);Endoxanal;CP;Senduxan;Zyklophosphamid;NCI C04900;Endoxan R;Endoxan-Asta;Endoxana;Mitoxan;Endoxane;Enduxan;CB 4564;SK 20501;CPA;CY;Hexadrin;Cyclophosphamidum;CTX;Semdoxan;Revimmune;Ledoxan;Cytophosphane;Eldamide;Neophos;Cyphos;Cydoxan;Cycrame;Oncomide;Cyclocel;Cycloxan;60007-95-6;75526-90-8
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CAS No:
Description
Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
Characteristics
41.6
0.63
Cyclophosphamide is a fine white crystalline powder. Odorless with a slightly bitter taste. Melting point 41-45°C. A 2% solution has pH of 4 to 6. Used medicinally as an antineoplastic agent.
1.48 g/cm³
49.5-53 °C
336°C
113°C c.c.
1.506
H2O: soluble . 1-5 g/100 mL at 23 ºC
Storage site should be as close as practicable to lab in which carcinogens are to be used, so that only small quantities required for expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion proof refrigerator or freezer (depending on chemicophysical properties ) that bears appropriate label. An inventory should be kept, showing quantity of carcinogen & date it was acquired Facilities for dispensing should be contiguous to storage area.
Vapour pressure, Pa at 25°C: 0.006 (calculated)
LD50 oral in rat: 100mg/kg
Odorless
Slightly bitter
Safety Information
III
6.1(b)
UN 1851
22-24/25
RP5950000
Separated from food and feedstuffs. Dry. Keep in the dark. Well closed. See Chemical Dangers.
Stable, but light sensitive. Incompatible with oxidizing agents.
P201, P202, P260, P263, P264, P270, P281, P301+P310, P307+P311, P308+P313, P314, P321, P330, P405, P501
H301
Cyclophosphamide Use and Manufacturing
An anti-proliferative agent that regulates Bax and Bcl-2 expression.
Computed Properties
Molecular Weight:261.08
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:260.0248201
Monoisotopic Mass:260.0248201
Topological Polar Surface Area:41.6
Heavy Atom Count:14
Complexity:212
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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