"DRI" in FOXO4-DRI is short for "D-retro-inverso": "Retro-inverso peptides are linear peptides whose amino acid sequence is reversed and the α-center chirality of the amino acid subunits is inverted as well.
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Semaglutide is a new generation GLP-1 (glucagon-like peptide-1) analogues. Semaglutide is a long-acting dosage form based on the basic structure of liraglutide, which is more effective in the treatment of type 2 diabetes mellitus. Compared with lilarlutide, somalutide has a longer aliphobic chain and an increased hydrophobicity, but somalutide is modified with a short chain of PEG, and its hydrophilicity is greatly enhanced.PEG modification can not only tightly bind to albumin, cover up the DPP-4 enzymatic hydrolysis site, but also reduce renal excretion, prolong the biological half-life, and achieve the effect of long circulation.
Molecular Weight: 4813.45
Appearance: White Powder
Purity (HPLC): ≥99.0%
Single Impurity (HPLC): ≤1.0%
Moisture Content (Karl Fischer): ≤10.0%
Peptide Content: ≥80.0%
Storage: Store at -20℃ degrees Celsius in a dry and cool place.
Storage Condition: Store at -20°C Solubility in DMSO: 3mg/mL (0.73 mM)
SEMAGLUTIDE & TIRZEPATIDE
GLP-1 agonists were approved by the FDA for weight loss in late 2014. It's a newer class of drugs better known for its ability to improve blood sugar control. These medications were actually designed to treat type II diabetes, but some have also been FDA approved to treat weight loss. The GLP-1 agonists we work with are called Semaglutide & Tirzepatide.
Tirzepatide is dosed at 5-15mg per week
Semaglutide is dosed at 0.5-2.4mg per week
Product Function:
- Helps slow food leaving your stomach
- Helps prevent your liver from making too much sugar
- Helps the pancreas produce more insul when your blood sugar levels are high
- Can help control blood glucose
- Can reduce hyperglycemia, especially after meals
- Can reduce fasting insul and fasting glucose
- Can reduce hemoglobin A1c
- Can decrease appetite and caloric intake, while inhibiting weight gain
- Has been shown to lower triglyceride levels and oxidative stress from high LDL
- Has been shown to help induce weight loss in obese patients with higher dosing
- Helps decrease leptin and increase leptin sensitivity
- Can increase the conversion of white fat to brown fat
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Peptide Storage Guidelines: General Tips
When storing peptides, remember to:
• Store peptide in a cold, dry, dark place
• Avoid repeated freezing and thawing of peptide
• Avoid overexposure to the air
• Avoid light exposure
• Avoid storing peptides in solution long term
• Aliquot peptide according to experimental requirements
1. All peptides and raws purity >=99% purity
Many HPLC test reports are available (Janoshik).
2. 100% Safe delivery
3. Oversea warehouses and stocks: USA, Canada, Europe and Australia.
4. Cheapest prices in the market, unbeatable！
5. Payment options: Credit card, bank transfer, wise, alipay, apple pay, google pay, wechat, bitcoin,usdt,Remitly,Money gram
Hazard Identification
Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Reproductive toxicity, Category 1A
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 4
GHS label elements, including precautionary statements
| Pictogram(s) |  |
| Signal word | Danger |
| Hazard statement(s) | H302 Harmful if swallowed H360 May damage fertility or the unborn child H413 May cause long lasting harmful effects to aquatic life |
| Precautionary statement(s) |
| Prevention | P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P273 Avoid release to the environment. |
| Response | P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P318 IF exposed or concerned, get medical advice. |
| Storage | P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
Other hazards which do not result in classification
Handling and Storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
Packing and shipping:
Company Profile
FAQ
Q1: May I get one sample before placing order?
Re: Yes, Sample are available. For normal products, samples are for free and you just need to bear the freight; For those high value products, you just need to freight and certain product cost. When we both cooperate for some times or when you are our VIP customer, free sample will be offered when you need.
Q2: Which payment is available for your company?
Re: Credit card, bank transfer, wise, alipay, apple pay, google pay, wechat, bitcoin,usdt,Remitly,Money gram etc. You can choose the one which is convenient for you.
Q3: How and when can I get my goods after payment?
Re: For small quantity products, they will be delivered to you by international courier(DHL, FedEx, TNT etc.) or by air. Usually it will cost 5-7days that you can get the goods after delivery.For large quantity products, shipping by see is worthwhile.It will cost 15 to 30 days to come to your destination port, which depends on where the port is.
Q4: Is there any possible to use my appointed label or package?
Re: Yes. If needed, we'd like to.
1. How to make payment?
We accept Alibaba trade assurance; Delivery after payment only.
2. How and when to deliver goods?
We delivery goods by Express, USA & EU special line/Royal Mail/UPS/USPS/DHL/Fedex/EMS/E packet.
By sea or by air are also used.
3. How to distinguish product quality?
You get what you paid for, we can't be the cheapest but product must be safe and good.
We can provide COA and HPLC test reports for your reference, and COA for the acutal lot before delivery for your evaluation. We always recommend testing quality first with trail order.
4. what can you buy from us？
hemical products、Industrial textile products、Plastic products、Rubber products、cosmetics、mechanical equipment、Hardware products.
5. why should you buy from us not from other suppliers?
Before-sale service, after sale technical consultancy service.
6. How to place order online?
Performa invoice will be sent after confirmation from the client along with our bank details. In the same time we also accept PO as an confirmation to prepare the shipment.
FOXO4-DRI (Retro-Inverso) is a synthetic, slightly modified version of the standard FOXO4 protein. The modification prolongs half-life of the protein and allows it to interfere with normal FOXO4 function. FOXO4-DRI has been shown in research to prevent normal FOXO4 binding to p53, thereby allowing for elimination of senescent cells, improved organ function, and younger tissue “biological age.” FOXO4-DRI impacts insulin signaling, cell cycle regulation, and oxidative stress signaling pathways. FOXO4-DRI is a cell penetrating peptide shown to selectively induce apoptosis of senescent cells thereby reversing effects of aging in animal studies.
Research & Reference Note
factory supply Cosmetic Peptide Foxo4-DRI/ FOXO4 D-Retro-Inverso 99.5% Powder CAS 2460055-10-9 is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals
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