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High quality High Cardiovascular CAS NO 138402-11-6 Irbesartan with Discount

Name: High quality High Cardiovascular CAS NO 138402-11-6 Irbesartan with Discount
Brand: QSC=Qingdao Baishiwei Chemical
SKU: pr2408201627
Price: 3.09 USD
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CAS No.:

138402-11-6

Grade:

Pesticide Grade

Content:

99%

Port:

QINGDAO

Brand:

QSC=Qingdao Baishiwei Chemical

Packaging:

25kg drum

Price valid (until):

2025-01-24

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Description

Shop High quality High Cardiovascular CAS NO 138402-11-6 Irbesartan with Discount-Detailed Image 1

Description

Product Information

Product name	Irbesartan
CAS No.	138402-11-6
Molecular Formula	C25H28N6O
Molecular Weight	428.53
Quality Standard	98% up, USP/ EP
Appearance	White to almost white powder

COA of Irbesartan

ITEMS	STANDARDS	RESULTS
Appearance	White to off-white powder	White powder
Identification	Infrared absorption: The IR spectrum is consistent with that obtained with the reference	Conforms
Identification	The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the assay	Conforms
Water	NMT 0.5%	0.24%
Limit or Azide	NMT10ppm	Not detected
Heavy metals	NMT0.002%	Conforms
Related compounds (HPLC)	Compound A NMT0.2%	0.01%
	Any other impurity NMT0.1%	0.04%
	Total impurity NMT0.5%	0.09
Residual solvents(GC)	Ethanol NMT 5000ppm	2307 ppm
	Toluene NMT 890ppm	238 ppm
	Dichloromethane NMT3000 ppm	Not detected
	N,N-Dimethylformamide NMT880 ppm	Not detected
	T-butyl Methyl Ether NMT 5000 ppm	Not detected
Assay	98.0—102.0%	99.2%
Conclusion	The analysis results show that this batch of irbesartan conforms to USP

Function of Irbesartan

Irbesartan is an angiotensin Ⅱ (Angiotensin Ⅱ, Ang Ⅱ) receptor inhibitor, can inhibit the conversion of Ang Ⅰ to Ang Ⅱ, can specifically antagonize the angiotensin converting enzyme 1 receptor (AT1), the antagonism of AT1 is greater than AT28500 Double, by selectively blocking the binding of AngⅡ and AT1 receptors, inhibiting vasoconstriction and the release of aldosterone, resulting in a hypotensive effect. This product does not inhibit angiotensin converting enzyme (ACE), renin, other hormone receptors, nor does it inhibit ion channels related to blood pressure regulation and sodium balance. It is mainly used for the treatment of essential hypertension and type 2 diabetic nephropathy with hypertension.

Product Description

Celecoxib is a selective Cox-2(cyclooxygenase-2) inhibitor (IC50 of 40 nM). Celecoxib shows low sensitivity against Cox-1 (IC50 of 15 μM). Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 (IC50of 32.86 μM) and CNE1-LMP1 (IC50 of 61.31 μM).Celecoxib

Celecoxib is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain in adults, painful menstruation, and juvenile rheumatoid arthritis in people .

Celecoxibis a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain.

Product Detail

Celecoxib is a nonsteroidal antiinflammatory drug (NSAID) first launched as Celebrex in the US for the treatment of symptoms in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Celecoxib belongs to a new class of 1, 5-diarylpyrazoles and can be synthesized by heat-promoted heterocyclization of a trifiuoro-l,3-dione with appropriate arylhydrazine. Celecoxib is a highly selective inhibitor of COX-2, the inducible form of cyclooxygenase expressed during inflammatory processes; it does not block the constitutive form COX-1, thus suppressing the gastric and intestinal toxicity of most non-selective NSAIDs. The potency ratio COX1/COX2 on purified human enzymes was about 400. In several in vivo models of acute and chronic inflammation, Celecoxib demonstrated potent antiinflammatory activity without affecting gastric or urinary prostaglandin PGE2. In several clinical studies performed with patients suffering from osteoarthritis or rheumatoid arthritis, Celecoxib was shown to be well tolerated and to relieve pain and inflammation more efficiently compared with other standard NSAIDs; the gastrointestinal safety profile was significantly better than that of other NSAIDs. Interestingly, Celecoxib was approved for another indication in patients with familial adenomatous polyposis (FAP). A six-month clinical trial demonstrated a 28% reduction in the number of colorectal polyps with Celecoxib, compared to a 5% reduction with placebo.

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Shop Raw Materials Chemical China Supplier Price Pure Telmisartan Powder 144701-48-4-Detailed Image 4

Basic Info

Product Name:

Irbesartan

Other Name:

1,3-Diazaspiro[4.4]non-1-en-4-one,2-butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-;1,3-Diazaspiro[4.4]non-1-en-4-one,2-butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-;2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one;SR 47436;2-Butyl-3-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]-1,3-diazaspiro[4.4]non-1-en-4-one;Irbesartan;BMS 186295;Avapro;Aprovel;Karvea;2-Butyl-3-[[2′-(tetrazol-5-yl)biphenyl-4-yl]-methyl]-1,3-diazaspiro[4.4]non-1-en-4-one;Irbetan;Irbest;Kansartan;X-Tension;3-Butyl-2-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,4-diazaspiro[4.4]non-3-en-1-one;2-Butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one;2-Butyl-3-[2′-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1,3-diaza-spiro[4.4]non-1-en-4-one;Sabervel;200762-06-7

CAS No.:

138402-11-6

Molecular Formula:

C25H28N6O

InChIKeys:

InChIKey=YOSHYTLCDANDAN-UHFFFAOYSA-N

Molecular Weight:

428.53

Exact Mass:

428.53

EC Number:

1592732-453-0

UNII:

J0E2756Z7N

NSC Number:

758696

DSSTox ID:

DTXSID0023169

NCI Thesaurus Code:

C29130

Color/Form:

Crystals from 96% ethanol

ATC Code:

C09CA04|C09DA04|C - Cardiovascular system

HScode:

29332900

Categories:

Inhibitors

Characteristics

PSA:

87.1

XLogP3:

4.1

Appearance:

white to off-white

Density:

1.3±0.1 g/cm3

Melting Point:

180-181 °C

Boiling Point:

648.6±65.0 °C(Predicted)

Flash Point:

346.0±34.3 °C

Refractive Index:

1.690

Water Solubility:

DMSO: >25mg/mL

Storage Conditions:

-20°C Freezer

Vapor Pressure:

1.23X10-15 mm Hg at 25 deg C (est)

Henrys Law Constant:

Henry's Law constant = 7.04X10-15 atm-cu m/mol at 25 °C (est)

Collision Cross Section:

200.8 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|201.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|214.21 Å² [M-H]-

Experimental Properties:

Hydroxyl radical reaction rate constant = 3.72X10-11 cu cm/molec-sec at 25 °C (est)

See More Irbesartan Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Irbesartan Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
ghk cu

Location:
No. 33688 Jingshi East Road, High-tech Zone, Jinan City, Shandong Province, Jinan Comprehensive Bonded Zone Customs supervision warehouse supporting office area 101-B3

Payment Terms:
100% TT in advance

Average lead Time:
120

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
11-50

Year of Establishment:
2021
Country Product Purchase Quantity Date Posted

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High quality High Cardiovascular CAS NO 138402-11-6 Irbesartan with Discount

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