Methimazole CAS NO 60-56-0
2 Inquiries
60-56-0
Reagent Grade
99%
Shanghai
Dideu
100mg;1g;5g;10g
2024-10-13
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceMethimazole(Tapazole, Northyx) is an antithyroid medicine.Target: OthersMethimazole is an antithyroid drug, and part of the thioamide group. Like its counterpart propylthiouracil, a major side effect of treatment is agranulocytosis. Methimazole is a drug used to treat hyperthyroidism, a condition that occurs when the thyroid gland begins to produce an excess of thyroid hormone. The drug may also be taken before thyroid surgery to lower thyroid hormone levels and minimize the effects of t
Solid
Methimazole is a member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen. It has a role as an antithyroid drug.|Methimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones. It was first introduced as an antithyroid agent in 1949 and is now commonly used in the management of hyperthyroidism, particularly in those for whom more aggressive options such as surgery or radioactive iodine therapy are inappropriate. On a weight basis, methimazole is 10 times more potent than the other major antithyroid thionamide used in North America, [propylthiouracil], and is the active metabolite of the pro-drug [carbimazole], which is an antithyroid medication used in the United Kingdom and parts of the former British Commonwealth. Traditionally, methimazole has been preferentially used over propylthiouracil due to the risk of fulminant hepatotoxicity carried by the latter, with propylthiouracil being preferred in pregnancy due to a perceived lower risk of teratogenic effects. Despite documented teratogenic effects in its published labels, the true teratogenicity of methimazole appears to be unclear and its place in therapy may change in the future.|Methimazole is a Thyroid Hormone Synthesis Inhibitor. The mechanism of action of methimazole is as a Thyroid Hormone Synthesis Inhibitor.|Methimazole is an antithyroid medication which is now considered the first line agent for medical therapy of hyperthyroidism and Graves disease. Methimazole has been linked to serum aminotransferase elevations during therapy as well as to a clinically apparent, idiosyncratic liver injury that is typically cholestatic and self-limited in course.|Methimazole is a thioamide inhibitor of the enzyme thyroid peroxidase (TPO), with antithyroid activity. Upon administration, methimazole inhibits the metabolism of iodide and the iodination of tyrosine residues in the thyroid hormone precursor thyroglobulin by TPO; this prevents the synthesis of the thyroid hormones triiodothyronine (T3) and thyroxine (T4).|A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.Basic Info-
Product Name:
Methimazole
Other Name:2H-Imidazole-2-thione,1,3-dihydro-1-methyl-;Imidazole-2-thiol,1-methyl-;4-Imidazoline-2-thione,1-methyl-;1,3-Dihydro-1-methyl-2H-imidazole-2-thione;Basolan;Danantizol;Favistan;Frentirox;Mercaptazole;2-Mercapto-1-methylimidazole;Mercazole;Mercazolyl;Metazolo;Methimazole;1-Methyl-2-mercaptoimidazole;Metothyrine;Tapazole;Thacapzol;Thiamazole;Metothyrin;Thycapzol;Methimazol;Thymidazole;1-Methyl-1H-imidazole-2-thiol;1-Methylimidazole-2-thiol;Metotirin;Strumazol;Thiamazol;Thymidazol;N-Methyl-2-mercaptoimidazole;1-Methyl-4-imidazoline-2-thione;1-Methyl-2-mercapto-1H-imidazole;1-Methylimidazole-2(3H)-thione;2-Mercapto-1-methyl-1H-imidazole;N-Methylimidazolethiol;1-Methyl-1,3-dihydroimidazole-2-thione;1-Methylimidazole-2-thione;2-Mercapto-N-methylimidazole;NSC 38608;MMI;Methylmercaptoimidazole;Metizol;Thyrozol;1-Methyl-2,3-dihydro-1H-imidazole-2-thione;3-Methyl-1H-imidazole-2-thione;4708-61-6;85916-84-3
CAS No.:60-56-0
Molecular Formula:C4H6N2S
InChIKeys:InChIKey=PMRYVIKBURPHAH-UHFFFAOYSA-N
Molecular Weight:114.17
Exact Mass:114.17
BRN:108646
EC Number:200-482-4
UNII:554Z48XN5E
NSC Number:757111|38608
DSSTox ID:DTXSID4020820
NCI Thesaurus Code:C641
Color/Form:LEAFLETS FROM ALCOHOL|WHITE TO PALE BUFF, CRYSTALLINE SUBSTANCE; STARCH-LIKE IN APPEARANCE & TO TOUCH
ATC Code:H03BB02|H - Systemic hormonal preparations, excl. sex hormones and insulins
HScode:29332990
Categories:
Characteristics-
PSA:
47.4
XLogP3:-0.3
Appearance:White to slightly cream or pale buff Crystalline Powder
Density:1.35 g/cm3
Melting Point:146-148 °C
Boiling Point:280 °C
Flash Point:280°C
Refractive Index:1.633
Water Solubility:H2O: soluble
Storage Conditions:Refrigerator
Odor:FAINT, CHARACTERISTIC
PH:SOLN ARE PRACTICALLY NEUTRAL TO LITMUS
Collision Cross Section:117.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|117.1 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin sensitization, Category 1
Eye irritation, Category 2
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H317 May cause an allergic skin reaction
H319 Causes serious eye irritation
H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
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Certifications:
ISO Certificate,REACH
">Company Profile -
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
Philippines
Methimazole
200 KG Jan 31, 2024 
Nigeria
Methimazole
1 KG Sep 12, 2024 Post an enquiry for this product
