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HOE 140 Acetate Cas 138614-30-9 For treating hereditary angioedema with The Best Price

Name: HOE 140 Acetate Cas 138614-30-9 For treating hereditary angioedema with The Best Price
Brand: XINKAIYUE
SKU: pr2409241647
Price: 88 USD
Availability: InStock

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CAS No.:

138614-30-9

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Guangzhou port

Brand:

XINKAIYUE

Packaging:

10mg 20mg/vial,10 vials/box

Sample Available:

Yes

Price valid (until):

2024-10-24

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Haikou Mingheng Technology Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

L/C,O/A,100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

Tirzepatide,Retatrutide,Peptides

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Product Details
Seller Information

Description

Product Details

Product name	HOE-140	color	White
Product synonyms	HOE-140(Icatibant);HOE140;ICATIBANT;HOE140;CS-1399;Firazyr;HOE140SYNTHETIC>99% SELECTIVEB2BRADYKIN;HOE140Acetate	Paypment ways	Paypal; BankTransfer; MoneyGram;T/T
CAS number	138614-30-9	Shipping ways	UPS;FedEx;DHL;EMS;by air;by sea
Molecular formula	C59H89N19O13S.C2H4O2	Specification	5mg 10mg 15mg/vial
Molecular weight	1364.59	Origin	China
EINECS number	206-141-6	Production Capacity	5000kg/month
Storage conditions	-20°C	Customized	Acceptable
Solubility	DMSO: 65.0 (max concentration mg/mL); 47.63 (max concentration mM) Etha**l: 0.25 (max concentration mg/mL); 0.18 (max concentration mM) PBS (pH 7.2): 10.0 (max concentration mg/mL); 7.33 (max concentration mM)	MOQ	1 box

HOE-140

Biological activity
Icatibant Acetate is an antagonist of the bradykinin B2 receptor and can be used to treat hereditary angioedema.
In vitro study
Icatibant(10-30μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors).
In vivo study
Icatibant(10-30μM) potentiates angiotensin III, but not angiotensin II (contraction mediated by angiotensin AT1 receptors), and Lys-des-Arg9-bradykinin, but not des-Arg9-bradykinin (effects mediated by the bradykinin B1 receptors).
Animal Model:Female mice of the CBA/J(H-2k) strain.
Dosage:0.06,0.3,or1.5mg/kg.
Administration:Subcutaneous administration twice daily.
Result:The The length of the large intestine was 93.6±6.8mm with the 1.5mg/kg dosage and 94.0±4.1mm with the 0.3mg/kg dosage, showing a significant preventive effect on shortening.

Company Introduction

XINKAIYUE is mainly engaged in the export of fine chemicals, cosmetic raw materials, food additives, pharmaceutical intermediates and other products,  which are widely used in medicine, health products, cosmetics, nutritional supplements, food additives and other fields.
Our company has its own research and development team and production plant. Our company is dedicated to the development of  international markets. Our products are mainly exported to many countries and regions,
such as Europe, America, South-east Asia, the Middle East and Africa etc.
In addition，we have professional and experienced engineers and scientists, providing new polypeptide drug biosynthesis solutions, which help partners stay  ahead of the polypeptide drug discovery, clinical development and market production.

Company photos

Our advantage

rich experience
1. Our company is a professional and leading factory with many years of experience in the pharmaceutical field in China.
2. We have good feedback from customers all over the world.
OEM service
1.Add customer logo
2. Redesign labels and packaging boxes according to customer requirements
3. Bottle cap color can be customized
Shipping service
1. Shipped within 48 hours after payment is received.
2. Small orders are shipped via express door-to-door.
3. The goods arrive in 7-10 days
24 hours service
1.Reply your inquiry within 10 hours
2. Continuously track goods and update information to customers
3. After-sales service at any time

Packaging and shipping

FAQ:

Q: How to order this product?
A: You can click "chat now" , or write an email to my inbox, and send us a inquiry, leave your number if possible, we will contact with you as soon as possible, then we can talk order details.

Q: How long can I receive my ordered goods?
A: We ship by express door to door; you can receive it in 7-10 workdays.

Q: What liquid should I add into the vial? And how much liquid needed?
A: You can add sterile water or saline, 1 vial add 1ml liquid is ok.（Depends on the specific product situation）

Q: Will I have any side effects after using peptide?
A: If you just begin to use, it is better to follow doctor's prescription. And if there is no allergy or any uncomfortable symptom, you can continue to use but take it in a suitable dosage. A few people will have slight allergy reaction, but after your body get used to it, the allergy will be disappear and back to normal.

Q: How to store it?
A: If it hasn't been opened, just put it in cool dry place, if it is opened, you may put it in cold storage for 2-5 degree condition.

ECHEMI Editorial Reference

Although it is a rare disease, HAE is an autosomal dominant disorder that can be potentially life-threatening when swelling manifests itself within the upper airways. Antagonism of the constitutively expressed B2 receptor, therefore, would not only be beneficial in the treatment of HAE but also find application in inflammatory, allergic, and hyperalgesic disorders.Designed to possess enhanced metabolic stability with the inclusion of five non-proteinogenic amino acids, icatibant is a competitive and selective B2 receptor antagonist (devoid of activity against the inducible B1 receptor) with a Kiof 2.2±0.7 nM, and it is the first downstream targeting agent to receive regulatory approval. It joins purified C1 esterase inhibitor, danazol (an attenuated androgen), and tranexamic acid (an antifibrinolytic agent) as acute and prophylactic treatments for HAE.
ChEBI: An acetate salt obtained by combining icatibant with acetic acid. Used for the treatment of acute attacks of hereditary angioedema in adult patients.

Certificates

Basic Info

Product Name:

Icatibant Acetate

Other Name:

HOE-140 (Icatibant);HOE140; ICATIBANT;HOE 140;CS-1399;Firazyr;HOE 140 SYNTHETIC >99% SELECTIVE B2 BRAD YKIN;d-arg-l-arg-l-pro-l-hyp-gly-l-(2-thienyl)ala-l-ser-d-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-l-(2α,3β,7aβ)-octahydro-1h-indole-2-carbonyl-l-arg;Icatibant acetate, D-Arg-L-Arg-L-Pro-L-Hyp-Gly-L-(2-thienyl)Ala-L-Ser-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3β,7aβ)-octahydro-1H-indole-2-carbonyl-L-Arg;HOE 140 Acetate

CAS No.:

138614-30-9

Molecular Formula:

C59H89N19O13S.C2H4O2

InChIKeys:

HKMZRZUEADSZDQ-SUJPMXFINA-N

Molecular Weight:

1364.59

EC Number:

206-141-6

Color/Form:

White to off-white

Categories:

Polypeptide

Characteristics

Critical Temperature & Pressure:

-20°C

See More Icatibant Acetate Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Icatibant Acetate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Tirzepatide,Retatrutide,Peptides

Location:
Shop No. 47, Jixin Plaza, No. 26 Renmin Avenue, Renmin Street, Meilan District, Haikou City, Hainan Province

Payment Terms:
L/C,O/A,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
51-100

Year of Establishment:
2019
Haikou Mingheng Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of pharmaceutical intermediates, plant extracts, and other products. Products are widely used in health products, peptides and other fields. Our plant covers an area of 1000 m². The proposed workshop will be built according to GMP standards. We provide our customers with quality products and first-class service. Now, we can provide G-KG service to our customers.
- High-Quality Peptides: Our company specializes in premium-grade peptides, ensuring the highest standards of purity and efficacy. Each product undergoes rigorous testing to guarantee superior quality and performance.
- Cutting-Edge Technology: We leverage the latest advancements in peptide synthesis and production technology. Our state-of-the-art facilities and innovative processes enable us to deliver peptides with exceptional precision and consistency.
- Custom Solutions: We offer tailored peptide solutions to meet the specific needs of our clients. Whether you require bespoke formulations or custom quantities, our experienced team is dedicated to providing personalized support and solutions.
- Extensive Expertise: With years of experience in the peptide industry, our team of experts is well-versed in the complexities of peptide development and applications. We are committed to providing insightful guidance and technical support to help you achieve your goals.
- Comprehensive Product Range: Our diverse portfolio of peptide products covers a wide range of applications, including research, pharmaceutical development, and cosmetic formulations. This allows us to cater to various industries and meet different customer needs.
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HOE 140 Acetate Cas 138614-30-9 For treating hereditary angioedema with The Best Price

Product Details

Seller Information

Product Details

HOE-140

Company Introduction

Company photos

Our advantage

Packaging and shipping

FAQ:

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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