Busulfan CAS 55-98-1
1 Inquiries
55-98-1
Pharmaceutical Grade
99%
Shanghai
1kg/bag;25kg/Cardboard Drum
2025-01-31
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceBusulfan is a potent alkylator, with chemotherapeutic activity.
Myleran appears as white crystals or powder. (NTP, 1992)|Solid
Myleran appears as white crystals or powder. (NTP, 1992)|Busulfan is a methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant. It has a role as an insect sterilant, an antineoplastic agent, a teratogenic agent, a carcinogenic agent and an alkylating agent. It derives from a butane-1,4-diol.|Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.|Busulfan is an Alkylating Drug. The mechanism of action of busulfan is as an Alkylating Activity.|Busulfan is an orally administered anticancer alkylating agent used in the treatment of chronic myelogenous leukemia, as well as a parenterally administered myeloablative agent used in preparation of hematopoietic cell transplantation (HCT). Busulfan has been linked to transient serum enzyme elevations during therapy, to rare cases of cholestatic hepatitis, instances of nodular regenerative hyperplasia and, when given in high doses, to sinusoidal obstruction syndrome which can be severe and fatal.|Busulfan is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)|An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.Basic Info-
Product Name:
Busulfan
Other Name:1,4-Butanediol,1,4-dimethanesulfonate;1,4-Butanediol,dimethanesulfonate;Methanesulfonic acid,tetramethylene ester;GT 41;NSC 750;CB 2041;1,4-Bis(methanesulfonoxy)butane;Busulphan;1,4-Dimethanesulfonoxybutane;1,4-Dimethylsulfonyloxybutane;Mablin;Mitostan;Myelosan;Myleran;Tetramethylene bis[methanesulfonate];Busulfan;Misulban;Mielosan;Mileran;Milecitan;Sulfabutin;1,4-Bis(methanesulfonyloxy)butane;Leucosulfan;Mylecytan;Mielucin;1,4-Butanediol dimesylate;Glyzophrol;Butane-1,4-diyl bis(methanesulfonate);1,4-Dibutanediol dimethanesulfonate;Busulfex;GT 2041;Myeloleukon;X 149;Sulphabutin;2041CB;AN 33501;Mielevcin;NCI C01592;Citosulfan;Busilvex;Myran;4-Methylsulfonyloxybutyl methanesulfonate
CAS No.:55-98-1
Molecular Formula:C6H14O6S2
InChIKeys:InChIKey=COVZYZSDYWQREU-UHFFFAOYSA-N
Molecular Weight:246.3
Exact Mass:246.30
EC Number:200-250-2
UNII:G1LN9045DK
NSC Number:755916|750
UN Number:2811
DSSTox ID:DTXSID3020910
NCI Thesaurus Code:C321
Color/Form:White needles|Crystals
ATC Code:L01AB01|L - Antineoplastic and immunomodulating agents
HScode:2942000000
Categories:
Characteristics-
PSA:
104
XLogP3:-0.5
Appearance:Pale Brown Crystalline Powder
Density:1.56 g/cm3
Melting Point:114-118 °C
Boiling Point:464ºC at 760 mmHg
Flash Point:9℃
Refractive Index:1.471
Water Solubility:Decomposes in water
Storage Conditions:Hygroscopic, Refrigerator, Under Inert Atmosphere
Vapor Pressure:6.56X10-6 mm Hg at 25 deg C (est)
Toxicity:Peritoneal-rat LD50: 22 mg/kg; oral-mouse LD50: 110 mg/kg
Flammability characteristics:Thermal decomposition to emit toxic sulfur oxide fumes
Henrys Law Constant:Henry's Law constant = 5.16X10-10 atm-cu m/mol at 25 °C (est)
Experimental Properties:Hydroxyl radical reaction rate constant = 4.70X10-12 cu cm/molec-sec at 25 °C (est)
Air and Water Reactions:This compound is an alkylating agent which hydrolyzes in water. (NTP, 1992).
Reactive Group:Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
Reactivity Profile:MYLERAN is an alkylating agent which hydrolyzes in water. (NTP, 1992). Strong reducers may yield hydrogen sulfide.
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 2, Dermal
Acute toxicity - Category 2, Inhalation
Carcinogenicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H310 Fatal in contact with skin
H330 Fatal if inhaled
H350 May cause cancer
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
P203 Obtain, read and follow all safety instructions before use.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P320 Specific treatment is urgent (see ... on this label).
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Commercially available busulfan for injection concentrate should be stored in unopened ampules at 2-8 deg C. The manufacturer states that, when diluted as directed in 0.9% sodium chloride injection or 5% dextrose injection, busulfan solutions are stable for up to 8 hours when stored at room temperature (approximately 25 deg C), and the busulfan infusion must be completed during the 8-hour time period. Solutions of busulfan diluted in 0.9% sodium chloride injection also have been shown to be stable when refrigerated at 2-8 deg C for up to 12 hours, during which time the infusion must be completed.
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Seller Information
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Business Type:
Trader
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Main Products:
Estradiol,Progesterone,GS441524,4-Butylresorcinol,DeoxyArbutin,Coenzyme Q10
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Location:
XINYUAN DADUHUI PHASE 1, NO.258 TAOYUAN NORTH ROAD, LIANHU DISTRICT, XI 'AN , SHAANXI CHINA
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Payment Terms:
TT against copy of documents,100% TT in advance
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Average lead Time:
30
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2023
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
Taiwan, China
Busulfan
1 KG Oct 10, 2024 Post an enquiry for this product
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