High Purity Pharmaceutical Grade Antipsychotic Drug Material Clozapine Powder CAS 5786-21-0 Clozapine
3 Inquiries
5786-21-0
Industrial Grade
99.9%
Shanghai
SX
25kg/bag
2025-02-28
HPMC,Lithium Carbonate,Cellulose Acetate Tow,EVA resin,Terpene Resin,PP fiber
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceClozapine (HF 1854) is an antipsychotic used to treat schizophrenia. Clozapine is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for M1 receptor.
Solid
Clozapine is a benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia. It has a role as a serotonergic antagonist, a dopaminergic antagonist, an adrenergic antagonist, a histamine antagonist, a muscarinic antagonist, a second generation antipsychotic, a GABA antagonist, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, a xenobiotic and an environmental contaminant. It is a benzodiazepine, a N-methylpiperazine, a N-arylpiperazine and an organochlorine compound.|A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.|Clozapine is an Atypical Antipsychotic.|Clozapine was the first atypical antipsychotic approved for treatment of schizophrenia. Because it is associated with severe and potentially fatal side effects (agranulocytosis), its use is restricted to refractory schizophrenia, and monitoring during therapy is required. Clozapine therapy is associated with serum aminotransferase elevations and in rare instances has been linked to clinically apparent acute liver injury.|Clozapine is a synthetic dibenzo-diazepine derivative, atypical antipsychotic Clozapine blocks several neurotransmitter receptors in the brain (dopamine type 4, serotonin type 2, norepinephrine, acetylcholine, and histamine receptors). Unlike traditional antipsychotic agents, it weakly blocks dopamine type 2 receptors. It relieves schizophrenic symptoms (hallucinations, delusions, dementia). (NCI04)|A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.Basic Info-
Product Name:
Clozapine
Other Name:5H-Dibenzo[b,e][1,4]diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-;8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine;HF 1854;Clozapine;Leponex;Clozapin;Iprox;Clozaril;Asaleptin;Azaleptine;Cloril;Fazaclo;Klozapol;Azaleptin;Sizopin;Clozapex;Apo-Clozapine
CAS No.:5786-21-0
Molecular Formula:C18H19ClN4
InChIKeys:InChIKey=QZUDBNBUXVUHMW-UHFFFAOYSA-N
Molecular Weight:326.82
Exact Mass:326.82
EC Number:227-313-7
UNII:J60AR2IKIC
NSC Number:757429
DSSTox ID:DTXSID5022855
NCI Thesaurus Code:C28936
Color/Form:Yellow crystals from acetone-petroleum ether
ATC Code:N05AH02|N - Nervous system
HScode:2933990090
Categories:
Characteristics-
PSA:
30.9
XLogP3:3.23
Appearance:pale yellow
Density:1.3±0.1 g/cm3
Melting Point:183-184 °C
Boiling Point:489.2±55.0 °C at 760 mmHg
Flash Point:9℃
Refractive Index:1.681
Water Solubility:ethanol: 1 mg/mL
Storage Conditions:Store at RT
Vapor Pressure:1.12X10-8 mm Hg at 25 deg C (est)
Toxicity:LD50 in mice, rats (mg/kg): 61, 58 i.v.; 199, 260 orally (Lindt)
PKA:7.5None
Henrys Law Constant:Henry's Law constant = 9.29X10-15 atm-cu m/mol at 25 °C (est)
Dissociation Constants:7.5|pKa = 7.50|pKa1 3.70; pKa2 7.60|pKa1 = 3.92 (imine); pKa2 = 7.75 (amine); pKa3 = 15.90 (secondary amine) (est)
Collision Cross Section:178.8 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|177.5 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Hydroxyl radical reaction rate constant = 3.76X10-10 cu cm/molecule-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Germ cell mutagenicity, Category 2
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H341 Suspected of causing genetic defects
H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry and well-ventilated place.
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Seller Information
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Business Type:
Trader
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Main Products:
HPMC,Lithium Carbonate,Cellulose Acetate Tow,EVA resin,Terpene Resin,PP fiber
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Location:
Building 4, Feicui Building, No. 366 Xinshi North Road, Qiaoxi District, Shijiazhuang City, Hebei Province
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Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
51-100
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Year of Establishment:
2024
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Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
United Kingdom
Clozapine
25 KG Oct 30, 2024 
Netherlands
Clozapine powder
25 KG Oct 21, 2024 
India
Clofozine
1.00 KG Feb 20, 2024 Post an enquiry for this product
