Factory Supply High Quality Docetaxel Anhydrous API CAS 114977-28-5

Product Description:

Product Name	Docetaxel
Synonyms	Benzenepropanoicacid,β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester,(αR,βS)-;DocetaxelN-debenzoyl-N-tert-butoxycarbonyl-10-deacetyltaxol;Taxotereanhydrous;Decetaxel;TAXOTERE;n-debenzoyl-n-tChemicalbookert-butoxycarbonyl-10-deacetyltaxol;)benz(1,2-b)oxet-9-ylester,(2ar-(2a-alpha,4-beta,4a-beta,6-beta,9-alpha(alph;Benzenepropanoicacid,b-[[(1,1-dimethylethoxy)carbonyl]amino]-a-hydroxy-,(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester,(aR,bS)-
MOQ	1kg
CAS	114977-28-5
Appearance	NEAT
Molecular Formula	C43H53NO14
Molecular Weight	807.88
Assay	>99%
Application	For research purpose only
Packing	25kg/drum
Storage	Store in a well-closed,light-resistant container

Docetaxel is a semi synthetic derivative of paclitaxel, which is extracted from the European yew tree as a monomer 10 deacetylated berry gibberellin and is a hydrophilic anti-tumor drug. Similar to the mechanism of action of paclitaxel, it binds to microtubule proteins, promotes microtubule stability, and leads to G2/M cell cycle arrest.
Docetaxel is a paclitaxel class drug that promotes the assembly of microtubule dimers into microtubules, while stabilizing microtubules by preventing depolymerization, blocking cells in the G2 and M phases, thereby inhibiting cancer cell mitosis and proliferation. Docetaxel has stronger pharmacological effects than paclitaxel, with a concentration three times higher in cells and a longer retention time. Its affinity for microtubules is twice that of paclitaxel; As a microtubule stabilizer and assembly promoter, its activity is twice that of paclitaxel; As a microtubule depolymerization inhibitor, its activity is twice that of paclitaxel. In vitro anti-tumor activity tests have confirmed that the anti-tumor activity of docetaxel is 1.3-12 times that of paclitaxel. Clinical studies have shown that docetaxel is more effective than paclitaxel in anthracycline resistant breast cancer. Docetaxel is by far the most effective drug in the second-line treatment of anthracycline resistant breast cancer; Docetaxel is one of the most effective drugs in monotherapy and combination chemotherapy for non-small cell lung cancer. Genetic toxicity: Docetaxel showed a mutagenic effect in CHO-K1 cell chromosome aberration assay and mouse bone marrow micronucleus assay, but no mutagenic effect was observed in Ames assay and CHO/HGPRT gene mutation assay. Reproductive toxicity: Intravenous injection of docetaxel 0.3mg/kg in rats (approximately 1/50 of the clinically recommended dose based on body surface area) did not cause any damage to fertility, but could lead to a reduction in testicular weight. This result is correlated with the results of repeated administration trials in rats and dogs for 10 cycles (once every 21 days for 6 consecutive months); When rats and dogs were intravenously injected at doses of 5mg/kg and 0.375mg/kg, respectively (equivalent to approximately 1/3 and 1/15 of the clinically recommended dose, respectively, based on body surface area), testicular atrophy and degeneration were observed. Increasing the frequency of administration at low doses also showed similar effects in rats. The use of docetaxel during pregnancy can cause fetal damage. During organ formation, rats and rabbits were given docetaxel at doses of ≥ 0.3mg/kg/day and 0.03mg/kg/day, respectively (equivalent to 1/50 and 1/300 of the recommended clinical daily dose, respectively, based on body surface area). Embryotoxicity and fetal toxicity were observed, manifested as intrauterine death, increased fetal absorption, decreased fetal weight, and delayed ossification. The above doses can also cause maternal toxicity. There is currently insufficient and strictly controlled clinical research data on pregnant women. If patients use this product during pregnancy or become pregnant while using this product, they should be informed of the potential harm to the fetus and the potential risk of miscarriage. Women who have the potential to conceive should avoid pregnancy during the use of this product for treatment. It is not yet clear whether docetaxel is excreted from human milk. Given that many drugs can be excreted from human milk and docetaxel may cause serious adverse reactions in nursing infants, mothers should stop breastfeeding before using this product.


Product Function:
1. It is applicable to the treatment of locally advanced or metastatic breast cancer.
2. Suitable for the treatment of locally advanced or metastatic non-small cell lung cancer, even after the failure of cisplatin based chemotherapy.


Application:
1. Anti cancer drugs. Used for uterine cancer.
2. Antineoplastic plant medicine, used for the treatment of metastatic breast cancer and non-small cell lung cancer
3. Docetaxel can be used in the study of antibiotics, cell biology, cell signaling, neuroscience, cell apoptosis, and cell cycle. Docetaxel is also used to study hair loss caused by docetaxel chemotherapy, prevent and treat non-small cell lung cancer in patients with contraindications to standard chemotherapy. Docetaxel has also been used to investigate the effects of hypoxia inducible factor-1 α and 2 α on androgen insensitive prostate cancer cells.

FAQ:

1. What's the MOQ?

Generally the MOQ is 1kg, Best 25KG/DRUM

1. Is there any discount?

Yes, we will give you the best discount according to the size of your order!

1. How can I confirm the product quality before placing orders?

We will send you the existing sample or prepare the sample according to your request and send it to you for your confirmation!

1. How do you treat quality complaint?

If the quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately!

1. How to contact with us ?

Through SKYPE, WHATSAPP, WeChat, and E-mail.

1. How to place an order & payment ?

(1). Conduct product consultation,
(2). Determine the sample,
(3).After the sample quality meets the requirements, send us the PO,
(4). We reply to PI
(5). The customer completes the payment,
(6). Receive payment for goods, export products,
(7). The customer receives the goods and completes the order.

Cooperative customers:
Our products are exported to European and American countries.
It also has a large customer base in Southeast Asia and other regions.

After-sale service:
If the quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately!
100% responsible person, safe and reliable, integrity first.