Supply High Quality USP/EP White Powder Docetaxel CAS 114977-28-5 for Anti-cancer

Docetaxel More Info

Docetaxel is a semi-synthetic chemotherapeutic agent belonging to the taxane family, primarily used in the treatment of various cancers, including breast, lung, prostate, and head and neck cancers. 

Mechanism of Action

Docetaxel's mechanism of action involves binding to β-tubulin, a component of microtubules, which stabilizes the microtubule structure and prevents their depolymerization. This stabilization disrupts the normal dynamic reorganization of the microtubule network necessary for cell division, leading to cell cycle arrest at the G2/M phase. Additionally, docetaxel downregulates the expression of the anti-apoptotic protein BCL-2, promoting apoptosis in malignant cells. By interfering with microtubule dynamics, docetaxel effectively induces programmed cell death (apoptosis) in cancer cells.

Applications

Breast Cancer: Used in both adjuvant and metastatic settings.
Non-Small Cell Lung Cancer (NSCLC): Effective as a first-line treatment or in combination with other agents.
Prostate Cancer: Utilized in cases of hormone-refractory prostate cancer.
Ovarian Cancer: Often part of combination chemotherapy regimens.
Head and Neck Cancers: Employed in various treatment protocols.

Routes of Administration

Docetaxel is administered intravenously, typically as an infusion over a period of 1 hour. The standard dosing regimen is often 100 mg/m² every three weeks, although variations exist based on specific clinical circumstances.

Safety and Side Effects

Docetaxel is associated with a range of potential side effects:
Common Side Effects:
Fatigue
Nausea and vomiting
Hair loss
Neutropenia (low white blood cell count)
Fluid retention (edema)
Serious Side Effects:
Allergic reactions, including anaphylaxis
Severe gastrointestinal complications (e.g., enterocolitis)
Pneumonitis (lung inflammation)
Cardiac effects such as changes in heart rate or blood pressure
Neurological effects including peripheral neuropathy
Patients are monitored closely for these adverse effects, especially during the first few cycles of treatment.

Pharmacokinetics

Absorption: Following intravenous administration, docetaxel exhibits pharmacokinetics consistent with a three-compartment model. The area under the curve (AUC) is dose-proportional within the therapeutic range.
Distribution: It has a mean volume of distribution of approximately 74 L/m² after standard dosing. Docetaxel is highly protein-bound (>90%).
Metabolism: Primarily metabolized by the liver via the cytochrome P450 enzyme CYP3A4, leading to several metabolites. The clearance rate can be affected by factors such as age, liver function, and concurrent medications.
Elimination: Renal excretion is minimal (<5%), with biliary excretion being the primary route for elimination.

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FAQ

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We can send you a samll free sample, and you only need to pay for the shipping cost.

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For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

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Suitable for more than 50kg 
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For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

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