Benzhexol hydrochloride.
3 Inquiries
52-49-3
98%
SHANGHAI
25KG
2024-11-30
Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate
-
Product Description
-
Seller Information
-
Inquiry History
-
DescriptionECHEMI Editorial ReferenceTrihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class, binds to the M1 muscarinic receptor.
Trihexyphenidyl hydrochloride is an aralkylamine.|One of the centrally acting MUSCARINIC ANTAGONISTS used for treatment of PARKINSONIAN DISORDERS and drug-induced extrapyramidal movement disorders and as an antispasmodic.
Trihexyphenidyl is an antagonist of M1muscarinic acetylcholine receptors. It binds to rat M1receptors in cerebral cortex selectively over rat M2receptors in heart tissue (IC50s = 3.7 and 31 nM, respectively). Trihexyphenidyl inhibits contractions induced by acetylcholine in guinea pig ileum (IC50= 22 nM). It also inhibits oxotremorine-induced tremors and physostigmine-induced mortality in mice (ED50s = 2 and 3.6 mg/kg, respectively). Trihexyphenidyl (20 mg/kg) improves abnormal movement in a mouse model of L-3,4-dihydroxyphenylalanine (L-DOPA) responsive dystonia (DRD) that expresses mutant tyrosine hydroxylase (TH). Formulations containing trihexyphenidyl have been used in the symptomatic treatment of Parkinson''s disease.
Benzhexol hydrochloride is White Solid
ChEBI: Trihexyphenidyl hydrochloride is an aralkylamine.Basic Info-
Product Name:
Benzhexol hydrochloride
Other Name:TRIHEXYLPHENIDYL HYDROCHLORIDE;1-phenyl-1-cyclohexyl-3-piperidyl-1-propanolhydrochloride;3-(1-piperidyl)-1-cyclohexyl-1-phenyl-1-propanolhydrochloride;alpha-cyclohexyl-alpha-phenyl-1-piperidinepropanohydrochloride;artanehydrochloride;benzhexolchloride;cyclodol;pacitane
CAS No.:52-49-3
Molecular Formula:C20H31NO.ClH
InChIKeys:QDWJJTJNXAKQKD-UHFFFAOYSA-N
Molecular Weight:337.93
Exact Mass:337.217255
EC Number:200-142-5
NSC Number:757357
DSSTox ID:DTXSID8045802
Color/Form:white
HScode:2933399090
Categories:
Characteristics-
PSA:
23.47000
XLogP3:5.07040
Appearance:white solid
Density:0.9801 (rough estimate)
Melting Point:Free base, mp 114.3-115.0°
Boiling Point:447.9ºC at 760mmHg
Flash Point:211ºC
Refractive Index:1.5790 (estimate)
Water Solubility:670.9ug/L(22.5 ºC)
Toxicity:TDLo orl-wmn: 800 mg/kg:BAH BJPYAJ 145,300,84
Flammability characteristics:Combustion produces toxic nitrogen oxides and hydrogen chloride fumes; drug side effects: misinterpretation, hallucinations, eye diseases, confusion
Collision Cross Section:174.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Critical Temperature & Pressure:Inert atmosphere,Room Temperature
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Agrochemicals,Daily Chemicals,Catalysts & Chemical Auxiliary Agents,Extract,Inorganic Chemicals,Organic Intermediate
-
Location:
hisense intelligence valley,no 2116,of phoenix road
-
Payment Terms:
TT against copy of documents,D/P,L/C
-
Average lead Time:
7
-
Total Annual Revenue:
Less than $1 million
-
Total Employees:
11-50
-
Year of Establishment:
2017
-
-
Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
Indonesia
Benzhexol Hydrochloride
20 KG Nov 19, 2024 
Sri Lanka
Benzhexol Hydrochloride BP 2024 / BP 2025
100 KG Jun 13, 2026
Indonesia
Benzhexol HCl
100 MT Oct 30, 2024 Post an enquiry for this product
