API Tilmicosin

Name	Tilmicosin
CAS number	108050-54-0
Synonym	Micotil; Tilmicosine; Tilmicosinum
Related CAS	137330-13-3 (phosphate)   108050-54-0 (free base)
Description	Tilmicosin is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia haemolytica.
Structure
Molecular Formula	C46H80N2O13
Molecular Weight	869.147
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>3 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Tobramycin More Info

Tilmicosin is a macrolide antibiotic widely used in veterinary medicine.

Chemical Structure and Properties

Tilmicosin has a unique chemical structure within the macrolide family. It consists of a large macrocyclic lactone ring with specific side groups attached. This structure confers it certain physical and chemical properties. It is usually in the form of a white to off - white powder, and has specific solubility characteristics. For example, it has limited solubility in water but better solubility in some organic solvents.

Mechanism of Action

It acts by binding to the 50S ribosomal subunit of bacteria, which inhibits protein synthesis. This interference with the bacterial protein - making machinery results in the suppression of the growth and reproduction of susceptible bacteria. It is particularly effective against Gram - positive bacteria such as Staphylococcus, Streptococcus, and some mycoplasmas.

Applications in Veterinary Medicine

Respiratory Tract Infections

In livestock, especially in cattle and pigs, tilmicosin is commonly used to treat respiratory infections. For instance, in cases of bovine respiratory disease complex (BRDC), which is often caused by a combination of viral and bacterial pathogens including Mannheimia haemolytica and Pasteurella multocida, tilmicosin can be very effective in controlling the bacterial component of the infection. It helps to reduce symptoms such as coughing, fever, and nasal discharge.

Mycoplasma Infections

It is also a key drug for mycoplasma - related diseases. In poultry, it can be used to combat mycoplasma infections that affect the respiratory and reproductive systems. In swine, it can treat mycoplasma pneumonia, improving the growth performance and overall health of the animals by reducing the negative impact of the infection on the lungs and respiratory function.

Dosage and Administration

The appropriate dosage of tilmicosin depends on the species, age, and weight of the animals, as well as the severity of the infection. It can be administered through various routes, including injection and oral administration. For injection, it is usually given intramuscularly. When administered orally, it may be in the form of a medicated feed or water additive. However, strict adherence to the recommended dosage is crucial as incorrect dosing can lead to potential toxicity issues.

Precautions and Side Effects

Tilmicosin can be toxic at high doses. In some animals, it may cause adverse reactions such as transient salivation, vomiting, or diarrhea. Special care should be taken when handling tilmicosin, as accidental self - injection in humans can cause severe local reactions and potential systemic toxicity. It is also important to consider withdrawal times when using tilmicosin in food - producing animals to ensure that residues in meat, milk, or eggs do not pose a risk to human consumers.