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Paliperidone- ECHEMI

5 Inquiries

Unit Price: Get Latest Price
CAS No.:

144598-75-4

Grade:

Pharmaceutical Grade

Port:

Any China Port

Packaging:

25 KGS/DRUM

Price valid (until):

2024-12-04

Company Type:
Distributor
Location:
China
Qualification:
Main Products:

API,Intermediate

  • Product Description

  • Seller Information

  • Inquiry History

  • Description


      Product Detail  


    Paliperidone is an atypical antipsychotic used in the treatment of schizophrenia and other schizoaffective or delusional disorders.

    Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. Paliperidone was approved by the FDA for treatment of schizophrenia on December 20, 2006. It is available as an extended-release tablet, a once-monthly intramuscular injection, an every-three-month intramuscular injection, and a twice-yearly gluteal injection.

    Items Specifications
    Type Small Molecule
    Groups Approved
    Weight Average: 426.4839
    Monoisotopic: 426.206718955
    Chemical Formula C23H27FN4O3

    Basic Info
    Product Name:

    Paliperidone

    Other Name:

    4H-Pyrido[1,2-a]pyrimidin-4-one,3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-;1,2-Benzisoxazole,4H-pyrido[1,2-a]pyrimidin-4-one deriv.;3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one;R 76477;9-Hydroxyrisperidone;Paliperidone;RO 76477;Invega;130049-86-4;130049-84-2;147687-18-1

    CAS No.:

    144598-75-4

    Molecular Formula:

    C23H27FN4O3

    InChIKeys:

    InChIKey=PMXMIIMHBWHSKN-UHFFFAOYSA-N

    Molecular Weight:

    426.48

    Exact Mass:

    426.48

    EC Number:

    1806241-263-5

    DSSTox ID:

    DTXSID7049059

    Color/Form:

    Crystals from 2-propanol

    ATC Code:

    N05AX13|N - Nervous system

    HScode:

    29349990

    Categories:

    Other Chemical Drugs

    Characteristics
    PSA:

    82.2

    XLogP3:

    2.2

    Appearance:

    white to brown

    Density:

    1.45±0.1 g/cm3(Predicted)

    Melting Point:

    158-160°C

    Boiling Point:

    612.3±65.0 °C(Predicted)

    Flash Point:

    9℃

    Refractive Index:

    1.692

    Water Solubility:

    Practically insoluble in water;DMSO: soluble 2mg/mL, clear (warmed)

    Storage Conditions:

    room temp

    Vapor Pressure:

    1.3X10-15 mm Hg at 25 deg C (est)

    Henrys Law Constant:

    Henry's Law constant = 7.92X10-21 atm-cu m/mol at 25 °C (est)

    Dissociation Constants:

    pKa = 8.76 (est)

    Collision Cross Section:

    209.9 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

    Experimental Properties:

    Crystals from isopropanol /Paliperidone palmitate/

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 3, Oral

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    Response

    P301+P316 IF SWALLOWED: Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Distributor

    Main Products:

    API,Intermediate

    Payment Terms:

    TT against copy of documents,L/C

    Average lead Time:

    30

    Total Annual Revenue:

    Above $100 million

    Total Employees:

    201-300

    About Echemi Pharmaceutical 

    Echemi’s philosophy is to seek for higher quality, to explore frontier area. The progress of human society, the extension of life expectancy, and the conquest of disease are all derived from the numerous businesses and individuals who have quietly dedicated themselves in the pharmaceutical industry. It’s the controlling of supply chain quality that ensures the efficacy. It’s the continuous exploration that promotes the development of the pharmaceutical industry and benefits more future generations. The pursuit of high quality requires all partners of Echemi Pharmaceutical to be screened, whether its certificate, qualification or scale. In the field of renewal, we will embrace all new changes and make more contributions to the development of pharmaceutical industry.

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    Advantage for Pharmaceutical 

    • Having been working in pharmaceutical field for more then 15 years, we have experienced regulatory team, quality control team, sourcing team, technical support team, and logistics team. And we are familiar with the regulatory requirements from different areas, can offer tailored service for our customers.

    • We have hundreds of strategic partners for APIs, intermediates, and custom synthesis. All of our partners are ready to support our customers with documents, and be audited.

    • We can offer custom synthesis for some new chemical structures and some materials which there are no reliable suppliers.

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    Product Category 

    We care for human and animal health and we are committed to creating a better social environment.

    •  Human API

    • Intermediate

    • Veterinary API

    • Agrochemical

    • Fine Chemical

    • Custom Synthesis



  • Inquiry History
    5 Inquiries
    Country Product Purchase Quantity Date Posted
    Bahrain

    99% Raw Material Paliperidone CAS 144598-75-4 Pharmaceutical Powder Paliperidone

    42 KG Nov 14, 2023
    United States

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