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99% Paliperidone CAS 144598-75-4 Powder Fast Shipping Good Price

Name: 99% Paliperidone CAS 144598-75-4 Powder Fast Shipping Good Price
Brand: HyperChem
SKU: pr2502141026
Price: 120 USD
Availability: InStock

5 Inquiries

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CAS No.:

144598-75-4

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/Bag

Price valid (until):

2025-03-14

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Paliperidone
CAS number	144598-75-4
Synonym	Paliperidone; 9-Hydroxyrisperidone; Invega; 9-OH-risperidone; Invega Sustenna;
Description	Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class of medications. It is developed by Janssen Pharmaceutica. Invega is an extended release formulation of paliperidone that uses the OROS extended release system to allow for once-daily dosing.Paliperidone has antagonist effect at α1 and α2 adrenergic receptors and at H1 histamine receptors. It does not bind to muscarinic acetylcholine receptors. In addition, it binds with dopamine and serotonin receptors.
Structure
Molecular Formula	C23H27FN4O3
Molecular Weight	426.48 g/mol
Appearance	White Powder
Quality Standard	99%
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 2~8 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag, Bottle
Commercial package	Aluminium Tin
Origin	China

Paliperidone More Info

Mechanism of Action

Paliperidone is the primary active metabolite of risperidone. Its therapeutic activity is believed to be mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. Additionally, it acts as an antagonist at alpha-1 and alpha-2 adrenergic receptors and H1 histaminergic receptors.

Uses

Paliperidone is indicated for the treatment of schizophrenia and schizoaffective disorder. It helps reduce hallucinations, improve cognitive function, and enhance overall quality of life for patients. It is available in extended-release tablet form and as a long-acting injectable formulation.

Pharmacokinetics

Bioavailability: The absolute bioavailability of paliperidone is 28%.

Protein Binding: Approximately 74% bound to plasma proteins.

Metabolism: Metabolized via dealkylation, hydroxylation, dehydrogenation, and scission of the benzoxazole ring.

Excretion: Primarily excreted by the kidneys, with 59% of the dose excreted unchanged in urine.

Half-life: Terminal elimination half-life is approximately 23 hours.

Safety and Side Effects

Common side effects include dizziness, headache, somnolence, and weight gain. Paliperidone has a lower potential for drug interactions compared to other antipsychotics due to its lack of significant metabolism via cytochrome P450 enzymes.

Storage Conditions

Paliperidone should be stored in a cool, dry place, protected from moisture and light.

Conclusion

Paliperidone is an effective atypical antipsychotic medication with a favorable pharmacokinetic profile and reduced potential for drug interactions. Its availability in extended-release and long-acting formulations enhances patient compliance and makes it a valuable option for the treatment of schizophrenia and related disorders.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service

By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders:
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Basic Info

Product Name:

Paliperidone

Other Name:

4H-Pyrido[1,2-a]pyrimidin-4-one,3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-;1,2-Benzisoxazole,4H-pyrido[1,2-a]pyrimidin-4-one deriv.;3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one;R 76477;9-Hydroxyrisperidone;Paliperidone;RO 76477;Invega;130049-86-4;130049-84-2;147687-18-1

CAS No.:

144598-75-4

Molecular Formula:

C23H27FN4O3

InChIKeys:

InChIKey=PMXMIIMHBWHSKN-UHFFFAOYSA-N

Molecular Weight:

426.48

Exact Mass:

426.48

EC Number:

1806241-263-5

DSSTox ID:

DTXSID7049059

Color/Form:

Crystals from 2-propanol

ATC Code:

N05AX13|N - Nervous system

HScode:

29349990

Categories:

Other Chemical Drugs

Characteristics

PSA:

82.2

XLogP3:

2.2

Appearance:

white to brown

Density:

1.45±0.1 g/cm3(Predicted)

Melting Point:

158-160°C

Boiling Point:

612.3±65.0 °C(Predicted)

Flash Point:

9℃

Refractive Index:

1.692

Water Solubility:

Practically insoluble in water;DMSO: soluble 2mg/mL, clear (warmed)

Storage Conditions:

room temp

Vapor Pressure:

1.3X10-15 mm Hg at 25 deg C (est)

Henrys Law Constant:

Henry's Law constant = 7.92X10-21 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa = 8.76 (est)

Collision Cross Section:

209.9 Å² [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]

Experimental Properties:

Crystals from isopropanol /Paliperidone palmitate/

See More Paliperidone Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Paliperidone Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

5 Inquiries

Country	Product	Purchase Quantity	Date Posted
Bahrain	99% Raw Material Paliperidone CAS 144598-75-4 Pharmaceutical Powder Paliperidone	42 KG	Nov 14, 2023
United States	Paliperidone (generic Invega)	100 G	Jun 12, 2024
United States	Imiquimod (generic Aldara)	100 G	Jun 12, 2024
United States	Olanzapine (generic Zyprexa)	100 G	Jun 12, 2024
United States	Amlodipine (generic Norvasc) besylate	100 G	Jun 12, 2024

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