High Quality BP/USP Diphenhydramine Hydrochloride CAS 147-24-0 Pharmaceutical Raw Powder for anti-allergic

Diphenhydramine Hydrochloride More Info

Diphenhydramine is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic, and sedative properties that is mainly used to treat allergies. It is also used in the management of drug-induced parkinsonism and other extrapyramidal symptoms.

Mechanism of Action

Diphenhydramine primarily acts as an H1 receptor antagonist. By blocking histamine from binding to H1 receptors, it mitigates the effects of histamine in allergic reactions, leading to reduced symptoms such as sneezing, itching, and runny nose. It also possesses anticholinergic properties, which contribute to its sedative effects and can lead to side effects like dry mouth and urinary retention.

Applications:

Diphenhydramine is indicated for a variety of conditions:
Allergic Reactions: Effective for symptoms related to hay fever, allergic rhinitis, and urticaria.
Cold Symptoms: Alleviates sneezing, runny nose, and itchy/watery eyes.
Motion Sickness: Prevents nausea and dizziness.
Insomnia: Commonly used as a sleep aid due to its sedative effects.
Extrapyramidal Symptoms: Occasionally used to treat movement disorders associated with Parkinson's disease or antipsychotic medications.

Routes of Administration

Diphenhydramine can be administered through several routes:
Oral: Available in tablets, capsules, and liquid forms.
Topical: Creams and lotions for localized relief from itching.
Injectable: Administered intramuscularly or intravenously for acute allergic reactions or other medical conditions.

Safety and Side Effects

While diphenhydramine is generally safe when used as directed, it can cause several side effects:
Common Side Effects:
Drowsiness
Dry mouth
Dizziness
Constipation
Blurred vision
Serious Side Effects:
Hallucinations or delirium (especially at high doses)
Urinary retention
Increased heart rate
Confusion in older adults
Caution is advised when using diphenhydramine in young children due to potential safety concerns regarding cough-and-cold products.

Pharmacokinetics

Diphenhydramine is absorbed rapidly after oral administration, with peak plasma concentrations typically occurring within 1 to 2 hours. The drug has a half-life of approximately 4 to 8 hours. It is metabolized primarily in the liver and excreted through urine. Due to its ability to cross the blood-brain barrier, it exerts central nervous system effects leading to sedation.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
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Suitable for more than 50kg 
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Suitable for more than 500kg      
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We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

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