High Purity 99% Minocycline HCl CAS 13614-98-7 With Fast Delivery and Best Price

Minocycline More Info

Minocycline hydrochloride is a semi-synthetic antibiotic belonging to the tetracycline class. It is widely used for treating various bacterial infections and has additional properties that make it useful in several non-infectious conditions. 

Mechanism of Action

Minocycline exerts its antibacterial effects primarily through the inhibition of protein synthesis in bacteria. It achieves this by binding to the 30S ribosomal subunit, which prevents the attachment of aminoacyl-tRNA to the ribosome, thereby blocking the addition of new amino acids to the growing peptide chain. This action is bacteriostatic, meaning it inhibits bacterial growth rather than killing bacteria outright.

Applications:

Bacterial Infections:

Effective against both gram-positive and gram-negative bacteria, including:
Respiratory tract infections (e.g., pneumonia)
Urinary tract infections
Skin infections (e.g., severe acne)
Chlamydia and other sexually transmitted infections
Tick-borne diseases (e.g., Rocky Mountain spotted fever)
Non-Infectious Conditions:
Acne vulgaris: Often used as part of combination therapy.
Periodontitis: Helps reduce inflammation in gum disease.
Neurodegenerative diseases: Investigated for potential neuroprotective effects.
Additional Properties:
Anti-inflammatory Effects: Reduces inflammation in conditions like acne and periodontitis.
Antioxidant Properties: Scavenges free radicals, potentially offering neuroprotective benefits.
Immunomodulatory Effects: Modulates immune responses, which can be beneficial in treating autoimmune conditions.

Routes of Administration

Minocycline can be administered through various routes:
Oral: Available in capsules, tablets, and liquid forms. This is the most common method for outpatient treatment.
Injectable: Administered intravenously for severe infections or when oral administration is not feasible.
Topical: Formulations exist for localized treatment of acne or skin infections.

Safety and Side Effects

While generally well-tolerated, minocycline can cause side effects, including:
Common Side Effects:
Dizziness
Nausea
Vomiting
Diarrhea
Skin discoloration (blue-gray pigmentation)
Serious Side Effects:
Hypersensitivity reactions (e.g., rash, anaphylaxis)
Autoimmune reactions (e.g., drug-induced lupus)
Intracranial hypertension
Liver toxicity
Due to these potential side effects, monitoring is advised during treatment, especially in long-term use.

Pharmacokinetics

Minocycline exhibits distinct pharmacokinetic properties:
Absorption: Rapidly absorbed from the gastrointestinal tract; food may affect absorption by chelating with divalent cations (e.g., calcium).
Distribution: Highly lipophilic, allowing it to penetrate tissues effectively, including the central nervous system and skin.
Metabolism: Primarily metabolized in the liver; minor pathways involve conjugation with glucuronic acid.
Half-Life: Approximately 11 to 22 hours in healthy individuals; this extended half-life allows for less frequent dosing compared to other tetracyclines.
Excretion: Excreted mainly through urine as metabolites; a small percentage is eliminated unchanged.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
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Cosmetic Ingredients
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Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.