High-Quality Glycinamide Hydrochloride (CAS 1668-10-6) Supplied by China's Leading Professional Factory

Glycinamide hydrochloride More Info

Chemical Profile and Structural Characteristics

Glycinamide hydrochloride (CAS 1668-10-6) is the hydrochloride salt of glycinamide, a simple amino acid derivative with the molecular formula C₂H₆N₂O·HCl. This compound features a primary amide group adjacent to the amino function, creating a versatile molecular scaffold for chemical synthesis. The hydrochloride salt form enhances stability, improves crystallinity, and increases water solubility compared to the free base. With a molecular weight of 110.54 g/mol, it typically appears as a white to off-white crystalline powder with excellent purity characteristics suitable for pharmaceutical applications.

Synthetic Applications and Industrial Utility

As a key building block in organic synthesis, glycinamide hydrochloride serves as a fundamental precursor in numerous pharmaceutical manufacturing processes. It is extensively utilized in peptide synthesis as a C-terminal amide component and in the preparation of heterocyclic compounds including imidazoles, purines, and pyrimidines. The compound finds particular importance in nucleoside chemistry for the synthesis of glycineamide ribonucleotide (GAR) and in the production of various antiviral and anticancer agents. Its reactivity in acylation, alkylation, and condensation reactions makes it valuable for constructing complex molecular architectures.

Pharmaceutical Intermediates and Drug Synthesis

Glycinamide hydrochloride occupies a critical position in the synthesis of several important therapeutic agents. It serves as a key intermediate in the manufacturing of HIV protease inhibitors, particularly in the synthesis of amprenavir and related compounds. The pharmaceutical industry also employs it in the production of glycine receptor ligands, neuromodulatory agents, and various small molecule therapeutics targeting neurological conditions. Its incorporation into drug molecules often enhances water solubility and improves pharmacokinetic properties of the final active pharmaceutical ingredients.

Quality Specifications and Analytical Methods

We supply glycinamide hydrochloride meeting stringent quality standards with comprehensive specifications including identification by IR and HPLC, assay (98.0-101.0%), and of related substances. Critical quality parameters encompass chloride content, residue on ignition, heavy metals limits, and specific tests for ammonium salts and free glycine. Our analytical methods employ titration for assay determination and HPLC for impurity profiling, ensuring consistent quality and compliance with pharmaceutical grade requirements. Each batch is accompanied by a detailed Certificate of Analysis documenting compliance with all specified parameters.

Safety Profile and Handling Considerations

Glycinamide hydrochloride demonstrates a favorable safety profile with low acute toxicity, though standard laboratory precautions should be observed during handling. The compound may cause mild irritation to skin, eyes, and respiratory system upon direct contact or dust inhalation. Appropriate personal protective equipment including gloves, safety glasses, and dust masks is recommended when handling the material in industrial quantities. Proper ventilation and engineering controls should be implemented to maintain airborne concentrations below exposure limits in manufacturing environments.

Stability Profile and Storage Requirements

The compound exhibits excellent long-term stability when stored in well-closed containers protected from moisture and excessive heat at controlled room temperature. Glycinamide hydrochloride is hygroscopic and requires protection from high humidity conditions to prevent caking and maintain flow characteristics. Under recommended storage conditions, the material maintains chemical integrity for extended periods, with comprehensive stability data supporting a minimum shelf life of 36 months from the date of manufacture.

Regulatory Status and Compliance

Our glycinamide hydrochloride production complies with current Good Manufacturing Practices and is supported by comprehensive regulatory documentation. The compound is not classified as a controlled substance and is approved for use in pharmaceutical manufacturing in major international markets. We maintain detailed manufacturing records, quality control documentation, and provide necessary support for customer regulatory submissions including Drug Master Files and Certificates of Suitability where required.

Manufacturing Process and Scale-up Capabilities

We employ efficient synthetic routes starting from glycine derivatives through controlled ammonolysis and salt formation processes. Our manufacturing facilities utilize state-of-the-art reaction control systems and purification technologies to ensure high yield and exceptional purity. Scale-up capabilities support production from kilogram quantities to multi-ton batches, with rigorous in-process controls and comprehensive quality assurance throughout the manufacturing process. Multiple production sites ensure supply chain reliability for our global customer base.

Market Position and Supply Chain

As a fundamental building block in pharmaceutical synthesis, glycinamide hydrochloride maintains consistent demand across the fine chemical and pharmaceutical industries. The market is characterized by stable growth driven by ongoing drug development activities and the compound's versatility in synthetic applications. We maintain strategic inventory levels and robust logistics networks to ensure reliable supply, with flexible packaging options available to meet specific customer requirements from research quantities to bulk industrial scales.

Technical Support and Custom Solutions

We provide comprehensive technical support including synthetic pathway development, analytical method transfer, and regulatory consultation. Our research and development team offers custom synthesis services for specialized derivatives and tailored quality specifications to meet unique customer requirements. Collaborative partnerships are available for developing innovative applications and optimizing manufacturing processes, supported by our extensive experience in amino acid chemistry and pharmaceutical intermediates.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.