Supply 99% USP Standard Praziquantel White Powder CAS 55268-74-1 Ready Stock & Fast Delivery

Praziquantel More Info

Praziquantel is an anthelmintic medication primarily used to treat infections caused by parasitic worms, particularly those belonging to the Schistosoma genus, as well as other trematodes and cestodes. It is widely recognized for its efficacy, affordability, and minimal side effects, making it a crucial component in global health initiatives aimed at eliminating schistosomiasis by 2030.

Mechanism of Action

The exact mechanism of action of praziquantel (PZQ) is not fully understood, but several hypotheses have been proposed:
Calcium Ion Disruption: PZQ is believed to disrupt calcium ion homeostasis in the parasite by antagonizing voltage-gated calcium channels. This leads to an uncontrolled influx of calcium ions, resulting in muscle contraction and paralysis of the worms.
Targeting Specific Channels: Research indicates that PZQ may specifically target the β subunits of these calcium channels in schistosomes, which could explain its selective action against trematodes and cestodes.
Host Interaction: PZQ may also interact with host proteins, contributing to its overall anthelmintic effects. Activation of certain host receptors can lead to physiological responses that aid in displacing the worms from blood vessels.

Applications

Praziquantel is primarily used for treating:
Schistosomiasis: Effective against various species such as Schistosoma mansoni, S. japonicum, S. haematobium, and S. mekongi.
Cestode Infections: Including taeniasis and cysticercosis.
Other Trematode Infections: Such as clonorchiasis and opisthorchiasis.

Routes of Administration

Praziquantel is administered orally. The typical dosage varies based on the type of infection but generally involves a single dose or a short course of treatment.

Safety and Side Effects

While praziquantel is generally well-tolerated, some side effects may occur, including:
Common Side Effects: Abdominal pain, nausea, vomiting, headache, dizziness, malaise, and myalgia.
Serious Reactions: Allergic reactions such as urticaria or elevated liver enzymes have been reported.
Contraindications: Patients with hypersensitivity to praziquantel should avoid its use. Caution is advised in cases of ocular cysticercosis due to potential irreversible damage from parasite destruction.

Pharmacokinetics

Absorption: Approximately 80% of an oral dose is absorbed. Food intake can enhance bioavailability significantly.
Distribution: The volume of distribution is around 7695 L after a single dose, with about 80% bound to plasma proteins like albumin.
Metabolism: Praziquantel undergoes rapid metabolism via the cytochrome P450 enzyme system (primarily CYP3A) with a first-pass effect after oral administration.
Elimination: About 80% of the drug is excreted through the kidneys as metabolites. The elimination half-life ranges from 0.8 to 1.5 hours post-administration.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.