High Qulaity Dydrogesterone CAS 152-62-5 Pharmaceutical Grade White Powder

Dydrogesterone More Info

Dydrogesterone is a synthetic progestogen, primarily used in various gynecological and reproductive health applications. It mimics the action of natural progesterone, making it effective in managing conditions related to progesterone deficiency.

Mechanism of Action

Dydrogesterone acts as an agonist of the progesterone receptor (PR), selectively binding to both PR-A and PR-B isoforms. This selective binding allows it to promote uterine functions essential for maintaining pregnancy, such as decidualization and endometrial receptivity, without inhibiting ovulation or affecting the corpus luteum . Unlike other progestogens, dydrogesterone has minimal interactions with other hormonal pathways, which reduces the risk of unwanted side effects associated with androgenic or glucocorticoid activity.

Applications

Dydrogesterone is indicated for a variety of conditions, including:
Threatened or recurrent miscarriage
Dysfunctional uterine bleeding
Infertility due to luteal insufficiency
Dysmenorrhea (painful menstruation)
Endometriosis
Secondary amenorrhea
Irregular menstrual cycles
Premenstrual syndrome (PMS)
Menopausal hormone therapy

Routes of Administration

Dydrogesterone is administered orally. It is available in tablet form, typically dosed between 10 mg to 20 mg per day depending on the condition being treated.

Safety and Side Effects

Dydrogesterone is generally considered safe for use, especially during pregnancy when prescribed appropriately. Common side effects include:
Menstrual irregularities
Headaches
Nausea
Breast tenderness
Bloating
Weight gain.
Serious side effects may include:
Abnormal vaginal bleeding
Severe abdominal pain
Symptoms indicating potential overdose, such as vomiting or diarrhea.
While some concerns have been raised regarding the risk of venous thromboembolism and breast cancer associated with progestin use, studies specifically involving dydrogesterone have not confirmed these risks conclusively.

Pharmacokinetics

Dydrogesterone exhibits favorable pharmacokinetic properties:
Absorption: Rapidly absorbed after oral administration with a peak plasma concentration (Tmax) occurring between 0.5 to 2.5 hours.
Bioavailability: The absolute bioavailability is approximately 28% when taken orally compared to intravenous administration.
Metabolism: It is primarily metabolized by cytochrome P450 enzymes (notably CYP3A4), producing an active metabolite known as 20α-dihydrodydrogesterone (DHD), which has lower potency but significant progestogenic activity.
Half-life: The terminal half-lives are approximately 5 to 7 hours for dydrogesterone and 14 to 17 hours for DHD.
Excretion: About 63% of the dose is excreted in urine within 72 hours post-administration.

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