High Quality 99% White Powder Ezetimibe CAS 163222-33-1 with good price and fast delivery

Ezetimibe More Info

Ezetimibe is a lipid-lowering medication primarily used to manage hypercholesterolemia by selectively inhibiting intestinal cholesterol absorption.

Mechanism of Action

Ezetimibe works by targeting the Niemann-Pick C1-Like 1 (NPC1L1) sterol transporter located at the brush border of the small intestine. It inhibits the interaction between the NPC1L1/cholesterol complex and the clathrin/AP2 endocytic machinery, thereby preventing the endocytosis and uptake of cholesterol into enterocytes. This leads to reduced intestinal absorption of dietary and biliary cholesterol without affecting the absorption of fat-soluble vitamins or triglycerides.
The reduced cholesterol absorption decreases the delivery of cholesterol to the liver, which in turn increases hepatic clearance of cholesterol from the blood, lowering plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (apo B), and non-high-density lipoprotein cholesterol (non-HDL-C). Ezetimibe typically lowers LDL-C by 13% to 20% when used as monotherapy and has additive effects when combined with statins or fenofibrate.

Applications

Primary hyperlipidemia (high cholesterol)
Mixed hyperlipidemia
Homozygous familial hypercholesterolemia (HoFH)
Homozygous sitosterolemia (phytosterolemia)
Adjunct therapy with statins or fenofibrate to enhance cholesterol lowering
Used in fixed-dose combinations with statins such as simvastatin or rosuvastatin for enhanced effect.

Routes of Administration and Dosage

Route: Oral tablets
Dose: Usually 10 mg once daily
Can be taken with or without food; food does not significantly affect the extent of absorption, though high-fat meals can increase peak plasma concentration by about 38%.
When combined with bile acid sequestrants, ezetimibe should be taken at least 2 hours before or 4 hours after the sequestrant to avoid interference with absorption.

Safety and Side Effects

Generally well tolerated with a low incidence of adverse effects.
Common side effects may include headache, diarrhea, abdominal pain, and fatigue.
Does not significantly affect fat-soluble vitamin levels.
Caution in patients with moderate to severe hepatic impairment; use is not recommended in this population.
No dose adjustment is required for renal impairment.
Pregnancy Category C: Use only if potential benefits justify risks; bile acid sequestrants are preferred during pregnancy.
Avoid breastfeeding due to insufficient data on excretion in human milk.

Pharmacokinetics

Absorption: Rapidly absorbed and extensively conjugated in the intestine and liver to its active metabolite, ezetimibe-glucuronide.
Peak plasma concentrations: Ezetimibe peaks at 4 to 12 hours post-dose; ezetimibe-glucuronide peaks earlier, at 1 to 2 hours.
Protein binding: Both ezetimibe and its glucuronide metabolite are highly bound to plasma proteins (>90%).
Metabolism: Undergoes phase II glucuronidation primarily by UGT1A1, UGT1A3, and UGT2B15 enzymes.
Elimination: Excreted mainly via feces and urine as metabolites.
Half-life: Approximately 22 hours, supporting once-daily dosing.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.