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High Quality Mifepristone CAS 84371-65-3 with best price and fast delivery

Name: High Quality Mifepristone CAS 84371-65-3 with best price and fast delivery
Brand: HyperChem
SKU: pr2412251415
Price: 1000 USD
Availability: InStock

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CAS No.:

84371-65-3

Grade:

Pharmaceutical Grade

Content:

99%

Port:

SHANGHAI

Brand:

HyperChem

Packaging:

1kg/Bag, 25kg/drum

Sample Available:

Yes

Price valid (until):

2025-01-25

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Details
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Inquiry History

Description

Name	Mifepristone
CAS number	84371-65-3
EINECS number	617-559-7
Synonym	RU-486; RU 486; RU486; C-1073; C 1073; C1073; C-1073; Mifegyne; Mifepriston; Pictovir; Mifepristonum; Mifepristona; Corlux; (8S,11R,13S,14S,17S)-11-(4-(dimethylamino)phenyl)-17-hydroxy-13-methyl-17-(prop-1-yn-1-yl)-6,7,8,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Description	Mifepristone is a synthetic steroid compound used as a pharmaceutical. It is used as an abortifacient in the first two months of pregnancy, and in smaller doses as an emergency contraceptive. During early trials, it was known as RU-486, its designation at the Roussel Uclaf company, which designed the drug. The drug was initially made available in France, and other countries then followed—often amid controversy. It is marketed under tradenames Mifegyne and Mifeprex.
Structure
Molecular Formula	C29H35NO2
Molecular Weight	429.6 g/mol
Appearance	Solid powder
Quality Standard	CP Standard
Assay	≥98%
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Store in cool place. Keep container tightly closed in a dry and well ventilated place.
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China
HS Code	2937239090

Mifepristone More Info

Mifepristone, commonly known by its brand name Mifeprex, is a synthetic steroid with antiprogestational and antiglucocorticoid properties. It is primarily used for medical termination of early pregnancy and has applications in treating conditions related to excessive cortisol levels, such as Cushing's syndrome.

Mechanism of Action

Mifepristone acts primarily as a progesterone receptor antagonist. By binding to progesterone receptors, it inhibits the effects of progesterone, a hormone crucial for maintaining pregnancy. This antagonism leads to:
Termination of Pregnancy: Mifepristone disrupts the endometrial lining and induces uterine contractions, facilitating the expulsion of the pregnancy.
Glucocorticoid Antagonism: At higher doses, mifepristone also blocks cortisol at the glucocorticoid receptor, which can help manage conditions like hyperglycemia associated with Cushing's syndrome by counteracting the effects of excess cortisol.

Applications

Medical Termination of Pregnancy: Approved for use within 70 days (10 weeks) of gestation.
Cushing's Syndrome: Used to control hyperglycemia in patients with Cushing's syndrome who are not candidates for surgery or other treatments.
Other Potential Uses: Research is ongoing into its applications in conditions like uterine fibroids and certain hormone-dependent cancers.

Routes of Administration

Mifepristone is administered orally, typically as a single dose for medical abortion or in multiple doses for managing Cushing's syndrome.

Safety and Side Effects

Mifepristone can cause a range of side effects:
Common Side Effects:
Vaginal bleeding or spotting
Abdominal pain or cramps
Fatigue
Nausea
Headache
Serious Side Effects:
Severe vaginal bleeding
Infections (including severe bacterial infections post-abortion)
Anaphylactic reactions
Toxic epidermal necrolysis
Adrenal insufficiency due to glucocorticoid antagonism
Patients are advised to monitor for signs of severe complications such as heavy bleeding, persistent abdominal pain, or signs of infection following administration.

Pharmacokinetics

Absorption: Mifepristone is rapidly absorbed after oral administration, with peak plasma concentrations occurring approximately 90 minutes post-dose.
Distribution: It has high plasma protein binding (approximately 98%), primarily to albumin and alpha-1-acid glycoprotein. It can cross the blood-brain barrier.
Metabolism: Mifepristone is extensively metabolized in the liver via cytochrome P450 enzymes (CYP3A4, CYP2C8, CYP2C9, CYP2B6), producing several active metabolites that retain some pharmacological activity.
Elimination: The average elimination half-life ranges from 18 to 30 hours, depending on the dose and individual metabolism. Most of the drug is eliminated via feces.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service

By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

ECHEMI Editorial Reference

Mifepristone is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
Solid
Mifepristone is a 3-oxo-Delta(4) steroid, an acetylenic compound and a tertiary amino compound. It has a role as an abortifacient, a contraceptive drug, a synthetic oral contraceptive and a hormone antagonist. It derives from a hydride of an estrane.|Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary cushing syndrome. The two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials).|Mifepristone is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.|Mifepristone, also known as RU-486, is a potent synthetic steroidal antiprogesterone which is used as a single dose in combination with misoprostol, a prostaglandin analogue, to induce medical abortion. Mifepristone with misoprostol have not been associated with serum enzyme elevations or with clinically apparent liver injury.|Mifepristone is a derivative of the synthetic progestin norethindrone with antiprogesterone activity. Mifepristone competitively binds to the progesterone receptor, resulting in inhibition of the effects of endogenous or exogenous progesterone. This agent also exhibits antiglucocorticoid and weak antiandrogenic activities.|A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.

Certificates

Basic Info

Product Name:

Mifepristone

Other Name:

Estra-4,9-dien-3-one,11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1-propyn-1-yl)-,(11β,17β)-;Estra-4,9-dien-3-one,11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-,(11β,17β)-;(11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propyn-1-yl)estra-4,9-dien-3-one;RU 486;RU 38486;RU 486-6;R 38486;Mifepristone;Mifegyne;Mifestone;CDB 2477;Mifeprex;17β-Hydroxy-11β-[4-(dimethylamino)-phenyl]-17α-(prop-1-ynyl)-estra-4,9-dien-3-one;C 1073;VGX 410;MTPill;Pencrofton;122742-25-0;83203-42-3

CAS No.:

84371-65-3

Molecular Formula:

C29H35NO2

InChIKeys:

InChIKey=VKHAHZOOUSRJNA-GCNJZUOMSA-N

Molecular Weight:

429.59

Exact Mass:

429.59

EC Number:

1806241-263-5

UNII:

320T6RNW1F

DSSTox ID:

DTXSID5023322

NCI Thesaurus Code:

C655

Color/Form:

Yellow powder

ATC Code:

G03XB01|G - Genito urinary system and sex hormones

HScode:

29372900

Categories:

Hormones and the Endocrine System

Characteristics

PSA:

40.5

XLogP3:

4.5

Appearance:

Density:

1.2±0.1 g/cm3

Melting Point:

150 °C

Boiling Point:

628.6±55.0 °C at 760 mmHg

Flash Point:

334.0±31.5 °C

Refractive Index:

1.623

Water Solubility:

Poorly soluble

Storage Conditions:

2-8°C

Vapor Pressure:

8.0X10-14 mm Hg at 25 deg C /Estimated/

Specific rotation:

D20 +138.5° (c = 0.5 in chloroform)

Henrys Law Constant:

Henry's Law constant = 5.0X10-13 atm-cu m/mole at 25 °C /Estimated/

Experimental Properties:

Hydroxyl radical reaction rate constant = 5.1X10-10 cu cm/molec-sec at 25 °C /Estimated/|Ozone reaction rate constant = 1.4X10-14 cu cm/molec-sec at 25 °C /Estimated/

See More Mifepristone Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H360 May damage fertility or the unborn child
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Mifepristone Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Mifepristone	1 G	May 24, 2024

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High Quality Mifepristone CAS 84371-65-3 with best price and fast delivery

Product Details

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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