High Purity Azaperone Veterinary Grade Raw Material Powder CAS 1649-18-9 USP/EP Standard

Azaperone More Info

Azaperone is a synthetic compound belonging to the butyrophenone class of antipsychotic agents, structurally related to haloperidol. Chemically designated as 1-(4-fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone, it has the molecular formula C₁₉H₂₂FN₃O and a molecular weight of approximately 327.4 g/mol. The compound appears as a solid crystalline powder with a melting point of 91-93°C and is typically stored in cool, dry conditions for long-term stability. Azaperone is also known by synonyms such as Stresnil, Suicalm, and the developmental code R-1929.

The primary mechanism of action of azaperone involves antagonism of dopamine D₂ receptors in the central nervous system, producing a strong anticholinergic effect and neuroleptic sedation. As a dopaminergic antagonist, it binds to but does not activate dopamine receptors, thereby blocking the actions of endogenous dopamine or exogenous agonists. This pharmacological profile underlies its sedative and antiemetic properties, making it effective for calming animals without inducing full surgical anesthesia. The compound is classified as both an antipsychotic agent and a sedative-hypnotic.

In veterinary medicine, azaperone is primarily used as a tranquilizer for pigs, where it is administered to control aggression, reduce stress during transport, and facilitate handling. It is also occasionally used in other large animals including elephants. The drug is marketed under trade names including Stresnil for swine applications. In human medicine, azaperone has been used historically in the treatment of psychoses, though its clinical application in humans has largely been superseded by other antipsychotic agents.

Clinical research has investigated the pharmacodynamics of azaperone in pigs, including dose-response relationships for oral administration. Studies demonstrate that increasing oral doses of azaperone (4, 8, and 12 mg/kg body weight) produce faster onset of sedation, later termination of sedation, and longer overall sedation duration. However, higher doses are associated with adverse effects including decreased respiratory rate, reduced body temperature, altered biochemical parameters, and excessive immobility, indicating that elevated oral doses are not suitable for piglets. The pharmacokinetic profile shows that azaperone is partially metabolized to azaperol, and regulatory maximum residue limits are established for the sum of both compounds in porcine tissues.

The safety profile of azaperone has been evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Based on a no-observed-adverse-effect level (NOAEL) of 630 µg/kg body weight per day for neurobehavioral effects in dogs, an acceptable daily intake (ADI) of 0-6 µg/kg body weight was established with a 100-fold safety factor. Maximum residue limits (MRLs) in pigs are set at 60 µg/kg for muscle and fat, and 100 µg/kg for liver and kidney, expressed as the sum of azaperone and its metabolite azaperol. For laboratory handling, azaperone is classified as a hazardous material under DOT/IATA transport regulations (UN2811, Hazard Class 6.1, Packing Group III), indicating it is a toxic substance requiring appropriate safety precautions.

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.