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Factory Supply Estradiol/17-Beta Estradiol/ CAS:50-28-2 99% USP Raw Material

Name: Factory Supply Estradiol/17-Beta Estradiol/ CAS:50-28-2 99% USP Raw Material
Brand: HyperChem
SKU: pr2608171342
Price: 1.8 USD
Availability: InStock

TDS 36 Inquiries

Unit Price:

$1.8-2.2/G FOB

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CAS No.:

50-28-2

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/bag, 5kg/bag, 25kg/Drum

Price valid (until):

2028-06-30

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	17β-Estradiol
CAS number	50-28-2
Synonym	estradiol beta-Estradiol 50-28-2 17beta-Estradiol Oestradiol
Related APIs #	1. Estrone CAS:53-16-7 2. Estriol CAS:50-27-1 3. Ethinyl Estradiol CAS:57-63-6 4. Norethisterone CAS:68-22-4 5. Progesterone CAS:57-83-0 6. Mestranol CAS:72-33-3
Description	Our premium 17β-Estradiol (CAS 50-28-2) is a high-purity, laboratory-grade steroid compound tailored for academic research, biochemical experimentation, and pharmaceutical intermediate formulation. Also widely known as Oestradiol, this product features strict purity control, stable chemical properties, and precise molecular structure consistency, making it a reliable core material for life science research, metabolic mechanism studies, and biological laboratory applications. Processed under standardized purification and screening procedures, it eliminates impure ingredients and unstable impurities, ensuring consistent experimental repeatability and accurate research data for all laboratory scenarios. This 17β-Estradiol product presents as a white to off-white crystalline powder with stable physical and chemical parameters that meet international laboratory testing standards. Its core molecular specifications are fixed and verifiable: molecular formula C ₁ ₈H ₂₄ O ₂ , molecular weight 272.38 g/mol, exact mass 272.1776, and topological polar surface area of 40.5 Å². The compound owns a stable planar steroid nucleus structure with two hydrogen bond donor groups and two hydrogen bond acceptor groups, featuring zero rotatable bonds and a spatial complexity of 382, which endows it with specific molecular recognition capabilities in biological environments. It has a melting point of approximately 173°C, a boiling point of 445.9±45.0°C at 760 mmHg, and a refractive index of 1.599, with extremely low vapor pressure at room temperature, ensuring long-term structural stability under standard storage conditions. One of the core product advantages of our 17β-Estradiol is its ultra-high purity, reaching ≥ 99% HPLC tested grade. Every batch undergoes strict high-performance liquid chromatography detection, elemental analysis, and impurity screening to avoid structural analogs and residual contaminants that may interfere with experimental results. Different from low-purity crude extracts, this refined product maintains accurate stereochemical configuration with five defined atomic stereocenters, ensuring highly specific binding activity with biological target receptors. The standardized purification process strictly controls residual moisture and inorganic impurities, meeting USP-grade raw material standards and fully adapting to high-precision biochemical experiments and mechanism research requirements. In terms of biological mechanism, 17β-Estradiol is a classic endogenous estrogen ligand that mediates biological activities through two core estrogen receptor subtypes, ERα and ERβ. The specific β-hydroxyl group at the C17 position of its molecular structure enables it to efficiently bind to the ligand-binding domain of estrogen receptors, triggering receptor conformational changes and dimerization. After activation, the receptor complex translocates to the cell nucleus and binds to estrogen response elements (EREs) on target gene promoters, further recruiting coregulator proteins to adjust chromatin structure and regulate the transcription and expression of downstream target genes. This unique molecular interaction mechanism enables it to participate in modulating multiple biological processes, including cell proliferation and differentiation, lipid metabolism balance, bone metabolism regulation, and neurobiological activity adjustment. This research-grade material exhibits obvious dose-dependent biological activity and high receptor affinity, showing stable binding characteristics at nanomolar concentration levels. It effectively regulates key biological indicators such as inflammatory factor expression, osteoclast activity, and cellular metabolic sensitivity, serving as an essential standard reagent and experimental tool for studying estrogen signaling pathways, endocrine regulation mechanisms, and cell physiological functions. Its stable molecular activity and precise structural specificity make it widely applicable in university laboratories, scientific research institutions, and biotech enterprise experimental projects, covering endocrinology, neurology, metabolic biology, and pharmaceutical intermediate research fields. In terms of storage and stability, 17β-Estradiol powder boasts excellent shelf stability. Sealed storage at -20°C can maintain full activity for 3 years, and stable storage at 4°C for 2 years, with stable properties during normal room-temperature transportation, no easy decomposition or structural failure. The product is a common biochemical research reagent, non-classified UN hazardous goods, with safe physical properties and no volatile, explosive or corrosive characteristics. All products are strictly manufactured and tested to meet global laboratory safety standards, ideal for long-term scientific research storage and daily experimental use.
Molecular Formula	C ₁₈ H ₂₄ O ₂
Molecular Weight	272.4 g/mol
Appearance	White or almost white powder
Quality Standard	USP/EP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0-28℃ for short term (days to weeks) or 0-8 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Double plastic bags inside, fiber drum outside, any quantity available.
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Product Image

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FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

Company profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

ECHEMI Editorial Reference

Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.

Certificates

Basic Info

Product Name:

Estradiol

Other Name:

Estra-1,3,5(10)-triene-3,17-diol (17β)-;Estradiol;(17β)-Estra-1,3,5(10)-triene-3,17-diol;Altrad;Bardiol;Beta-estradiol;Dihydrofollicular hormone;Dihydrofolliculin;Dihydromenformon;Dihydrotheelin;Dihydroxyestrin;Diogyn;Diogynets;3,17-Epidihydroxyestratriene;Estraldine;Dimenformon;Estrovite;Femestral;Femogen;Gynergon;Gynoestryl;Lamdiol;Macrodiol;Nordicol;Oestergon;Oestradiol;Oestroglandol;Ovahormon;Ovasterol;Ovastevol;Ovocyclin;Primofol;Profoliol;Progynon;Progynon DH;Syndiol;Theelin,dihydro-;Estra-1,3,5(10)-triene-3,17β-diol;Ginosedol;Estra-1,3,5(10)-triene-3,17-diol,(17β)-;β-Estradiol;(+)-3,17β-Estradiol;Oestra-1,3,5(10)-triene-3,17β-diol;3,17β-Dihydroxyestra-1,3,5(10)-triene;3,17β-Estradiol;Perlatanol;Aquadiol;Follicyclin;Corpagen;17β-Oestradiol;Estradiol-17β;Estrace;Compudose;Estraderm;Compudose 365;E 2;Compudose 200;Estrogel;Estraderm TTS;Oestrogel;Menorest;Systen;Evorel;Climaderm;13β-Methyl-1,3,5(10)-gonatriene-3,17β-ol;Estraderm TTS 50;Epiestriol 50;Estroclim 50;Dermestril;Climara;Oesclim;17β-Estradiol;Encore;Aerodiol;Divigel;Sandrena 1;Vagifem;Gelestra;Estraderm TTS 100;Zumenon;Vivelle;NSC 9895;Profoliol B;Ovocylin;Estring Vaginal Ring;Estroclim;Estradot;Femanest;Estrogel HBF;Absorlent Matrix;FemSeven;Estrapatch;Estraderm MX;Alora;Estasorb;Estredox;Estreva;Bio-E Gel;Benzogynestry;Estropause;Menostar;Evamist;Zesteem;Compudose 400;Compudose 100;Vivelle-Dot;Sprediol;Elestrim;873662-39-6;1050677-52-5;1206475-11-7

CAS No.:

50-28-2

Molecular Formula:

C18H24O2

InChIKeys:

InChIKey=VOXZDWNPVJITMN-ZBRFXRBCSA-N

Molecular Weight:

272.38200

Exact Mass:

272.38

EC Number:

200-023-8

HScode:

29372390

Categories:

Hormones and the Endocrine System

Characteristics

PSA:

40.46000

XLogP3:

3.60920

Appearance:

Solid

Density:

1.17g/cm3

Melting Point:

173-179 °C

Boiling Point:

445.9ºC at 760mmHg

Flash Point:

209.6ºC

Refractive Index:

1.599

Water Solubility:

Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.

Storage Conditions:

2-8ºC

Vapor Pressure:

6.38X10-9 mm Hg at 25 deg C (est)

Toxicity:

LD50 subcutaneous in rat: > 300mg/kg

Specific rotation:

Specific optical rotation at 25 °C for D (sodium) line: +76 deg at 25 °C/D to +83 deg at 25 °C/D (dioxane)

Odor:

Odorless

PKA:

10.46±0.03

See More Estradiol Properties 

Hazard Identification

Classification of the substance or mixture

Carcinogenicity, Category 2

Reproductive toxicity, Category 1A

Reproductive toxicity, Additional category for effects on or via lactation

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H351 Suspected of causing cancer H360 May damage fertility or the unborn child H362 May cause harm to breast-fed children H410 Very toxic to aquatic life with long lasting effects
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P263 Avoid contact during pregnancy and while nursing. P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment.
Response	P318 IF exposed or concerned, get medical advice. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Do not store unpouched. Apply immediately upon removal from the protective pouch.

See More Estradiol Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

36 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	oestrogen β-ESTRADIOL Estradiol 17β-Estradiol 17β-Oestradiol E2 98% Powder 50-28-2 Senwayer	100 MG	May 27, 2025
United States	99% β-estradiol CAS NO 50-28-2	20 G	Sep 5, 2024
United Kingdom	Factory Wholesale Estradiol Raw Materials 99% Powder CAS 50-28-2 EGC-Estradiol	3 KG	Jan 4, 2024
Australia	High Purity Beta-Estradiol Estrogen Drugs Estradiol Powder CAS 50-28-2	100 G	Nov 6, 2024
Australia	17 beta-estradiol powder (CAS 50-28-2	10 G	Sep 18, 2024
Hungary	High Purity Beta-Estradiol Estrogen Drugs Estradiol Powder CAS 50-28-2	5 G	Aug 16, 2026
Hungary	large image1 oestrogen β-ESTRADIOL Estradiol 17β-Est E2 98% Powder 50-28-2	12 G	Dec 30, 2025
Hungary	High Purity Beta-Estradiol Estrogen Drugs Estradiol Powder CAS 50-28-2	5 G	Jun 29, 2026
Hungary	High Purity Beta-Estradiol Estrogen Drugs Estradiol Powder CAS 50-28-2	12 G	Dec 30, 2025
France	Hormones Estradiol CAS No 50-28-2 with High Purity Estrogen Drugs	20000 MT	Aug 31, 2023
Switzerland	Hormones Estradiol CAS No 50-28-2 with High Purity Estrogen Drugs	10000 MT	Aug 27, 2023
United Kingdom	99% High Purity CAS 50-28-2 Estradiol with Favorable Price 99% white powder Lingding-91 Lingding	50 G	Nov 10, 2023
United States	17-Beta Estradiol	10 G	Sep 24, 2024
Japan	Estradiol	1 G	Aug 6, 2024
United Kingdom	Beta-Estradiol	10 G	Apr 16, 2026
Czech	estradiol	20 G	Nov 23, 2025
United States	bioidentical estradiol	1 KG	Dec 23, 2025
Bahamas	Estradiol	2 MT	Nov 18, 2025
Australia	Estradiol 99% Purity Estradiol Powder	100 G	Feb 13, 2025
Pakistan	Estradiol	25 G	Dec 2, 2024

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Factory Supply Estradiol/17-Beta Estradiol/ CAS:50-28-2 99% USP Raw Material

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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