High Quality Fluoxetine hydrochloride CAS 59333-67-4 with best price and fast delivery

Fluoxetine hydrochloride More Info

Fluoxetine hydrochloride, commonly known by its brand name Prozac, is a selective serotonin reuptake inhibitor (SSRI) primarily used to treat major depressive disorder, obsessive-compulsive disorder, bulimia nervosa, and panic disorder. It is one of the most widely prescribed antidepressants due to its efficacy and safety profile.

Mechanism of Action

Fluoxetine works by selectively inhibiting the reuptake of serotonin (5-hydroxytryptamine or 5-HT) in the brain. By blocking the serotonin transporter (SERT), fluoxetine increases the availability of serotonin in the synaptic cleft, enhancing serotonergic neurotransmission. This mechanism is thought to contribute to its antidepressant effects. Additionally, fluoxetine has mild activity at 5-HT2A and 5-HT2C receptors, although its primary action remains focused on serotonin reuptake inhibition.

Applications

Major Depressive Disorder: Effective in alleviating symptoms of depression.
Obsessive-Compulsive Disorder (OCD): Reduces compulsive behaviors and obsessions.
Bulimia Nervosa: Helps decrease binge-eating and purging behaviors.
Panic Disorder: Reduces the frequency and severity of panic attacks.
Premenstrual Dysphoric Disorder (PMDD): Used to alleviate severe premenstrual symptoms.

Routes of Administration

Oral Capsules: Commonly prescribed in doses of 20 mg or 40 mg.
Oral Tablets: Available in similar dosages as capsules.
Liquid Formulation: Used for patients who may have difficulty swallowing pills.

Safety and Side Effects

Common side effects associated with fluoxetine include:
Gastrointestinal Issues: Nausea, diarrhea, dry mouth, and loss of appetite.
Neurological Effects: Dizziness, headache, insomnia, tremors, and unusual dreams.
Sexual Dysfunction: Decreased libido, erectile dysfunction, and delayed orgasm.
Other Reactions: Sweating, fatigue, nervousness, and flu-like symptoms.
Serious side effects may include:
Suicidal Thoughts: Increased risk of suicidal ideation, particularly in young adults and adolescents.
Serotonin Syndrome: A potentially life-threatening condition characterized by agitation, hallucinations, rapid heart rate, fluctuations in blood pressure, increased body temperature, and muscle rigidity.
Allergic Reactions: Signs include rash, hives, difficulty breathing, or swelling of the face.

Pharmacokinetics

Absorption: Well absorbed after oral administration with a bioavailability of approximately 72%. Peak plasma concentrations are typically reached within 6 to 8 hours.
Distribution: Highly protein-bound (about 94%) primarily to albumin and alpha-1-acid glycoprotein. It has a large volume of distribution.
Metabolism: Metabolized mainly in the liver by cytochrome P450 enzymes (notably CYP2D6) to its active metabolite norfluoxetine. Fluoxetine itself also inhibits CYP2D6 and other cytochrome P450 enzymes.
Elimination Half-Life: The half-life of fluoxetine ranges from 1 to 4 days; however, its active metabolite norfluoxetine has a longer half-life of about 7 to 15 days. This long half-life contributes to a gradual onset of therapeutic effects.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.