Product description
Prucalopride CAS 179474-81-8 of Chemical Properties
Melting point 90.7°
Boiling point 481.4±45.0 °C(Predicted)
density 1.28
storage temp. 2-8°C
pka 13.65±0.20(Predicted)
form powder
color white to beige
Prucalopride is a potent and selective agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Kis = 2.5 and 8 nM for human 5-HT4A and 5-HT4B, respectively). Prucalopride is greater than 250-fold selective for 5-HT4 over a panel of 53 overexpressed receptors, including 5-HT subtypes, but does bind to human dopamine D4 and sigma-1 (σ1) receptors and mouse 5-HT3 receptors (Kis = 2.3, 3.7, and 3.8 μM, respectively). It induces contractions in guinea pig colon with an EC50 value of 33 nM, an effect that is blocked by the 5-HT4 antagonist GR113808 but not the 5-HT2A and 5-HT3 antagonists ketanserin and granisetron , respectively. It also facilitates non-cholinergic contractions induced by electrical stimulation. In fasted dogs, oral administration of prucalopride increases colonic motility by inhibiting distal colon contractions (ED50 = 0.04 mg/kg), an effect that is blocked by pretreatment with the 5-HT4 antagonist GR125487. Prucalopride (5-10 mg/kg, s.c.) increases acetylcholine and histamine levels in the rat prefrontal cortex by 2.4-fold and 3-fold, respectively, and increases the power of hippocampal theta oscillations. Formulations containing prucalopride have been used in the treatment of chronic idiopathic constipation.
Applications
Function and Application of Prucalopride CAS 179474-81-8
Procapride is an effective drug for the treatment of chronic constipation with few adverse reactions, mainly headache, dizziness and general adverse reactions such as diarrhea, abdominal pain and nausea, with no significant effect on the heart.
Product pictures
Henan Chenli Biotechnology Co., LTD. (formerly Henan Chenhui Machinery Co., LTD.) was established in 2009. It is one of the large chemical raw materials manufacturers such as Daily chemical industry，food, cosmetics, feed additives and amino acids. The companys mainstream products are mercaptans, thioether, bromine, amino acid products, benzofuranone, o-chlorobenzamide, phthalaldehyde and other pharmaceutical and pesticide intermediates, and specializes in chemical raw materials, additives (fragrances, paints, ink, plastics, food chemical, daily chemical, feed) intermediates and other industries.
Chenli Biotech now has two production bases in Zhengzhou Economic Development Zone in Henan Province and Linyi Economic and Technological Development Zone in Shandong Province. The factory covers a total area of more than 100,000 square meters, the total investment scale of 30 million , the company has more than 200 employees, of which about 30% are professional and technical personnel. The factory is fully built in accordance with GMP requirements and is equipped with standard laboratories. The laboratory is equipped with spectrophotometer, gas chromatograph, liquid chromatograph and other precision analytical instruments, to ensure that our products fully comply with AJI, USP, FCC, CP, EP and other quality standards.
Our company is a medium-sized chemical enterprise integrating R & D, production and operation, with a high-quality R & D team and an experienced management team. Currently, the company has synthetic extraction technology of multi-chemical products, and has large production lines such as mercaptan, thioether and bromine series. and the leading products are arbutin, -arbutin, kojic dipalmitic acid, vitamin C derivatives, sucrose octaacetate, Isooctyl mercaptoacetate, octadecyl mercaptan and other mercaptan series, di-sec-butyldisulfide and other sulfur ether series, bromo-octadecane and other bromo-octadecane, chlorododecane and other chlorine series, thiocarboxylic acid and its derivatives series, 2-ethylbutyric acid and its derivatives, alkyl phosphonic acid and other series products. Mainly used in rubber and plastic additives, food, medicine, pesticides, spices, metal surface treatment and polymer materials. After more than 20 years of development, it has formed several series products such as fine chemical intermediates, pharmaceutical and pesticide intermediates. Products are exported to Asia, Europe, America and other countries and regions, with a high degree of credibility and competitiveness. The company has obtained environmental protection, safety, product and other qualification certification.
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