High Quality Adenosine CAS 58-61-7 with best price and fast delivery

Adenosine More Info

Adenosine is a naturally occurring purine nucleoside that plays a crucial role in various physiological processes, including energy transfer, signal transduction, and regulation of blood flow. It is produced endogenously in the body and is involved in numerous metabolic pathways. As a pharmacological agent, adenosine is utilized primarily for its effects on the cardiovascular system, particularly in the management of certain types of tachycardia.

Mechanism of Action

Adenosine exerts its effects through the activation of purinergic adenosine receptors, which are classified into four main subtypes: A1, A2A, A2B, and A3. Each receptor subtype has distinct physiological roles:
A1 Receptors: Predominantly located in the heart, activation leads to decreased heart rate and reduced conduction through the atrioventricular (AV) node.
A2A and A2B Receptors: Found in vascular smooth muscle, these receptors mediate vasodilation and increase blood flow.
A3 Receptors: Involved in modulating immune responses and inflammation.
The rapid onset of action and short half-life of adenosine make it effective for acute interventions, particularly in cardiology.

Applications

Paroxysmal Supraventricular Tachycardia (PSVT): It is administered intravenously to restore normal heart rhythm by temporarily blocking conduction through the AV node.
Diagnostic Agent: Used during cardiac stress tests to induce controlled stress on the heart.
Research: Investigated for its potential roles in cancer therapy due to its effects on tumor microenvironments and immune modulation.

Routes of Administration

Adenosine is primarily administered via:
Intravenous Injection: For immediate therapeutic effects in acute settings such as PSVT.
Diagnostic Use: During cardiac stress testing procedures.

Safety and Side Effects

Common Side Effects
Commonly reported side effects of adenosine include:
Facial flushing
Chest discomfort or pain
Shortness of breath (dyspnea)
Dizziness or lightheadedness
Nausea
Serious Side Effects
More severe adverse reactions can occur, particularly with intravenous administration:
Cardiac Events: Risk of arrhythmias (including atrial fibrillation), hypotension, myocardial infarction, and cardiac arrest.
AV Block: Can cause first-, second-, or third-degree AV block or sinus bradycardia.
Allergic Reactions: Rarely, hypersensitivity reactions may occur.
Due to these potential side effects, adenosine should be used with caution in patients with pre-existing heart conditions or those showing signs of acute myocardial ischemia.

Pharmacokinetics

Absorption and Distribution
Adenosine has poor oral bioavailability due to rapid metabolism; thus, it is typically administered intravenously. Its effects are felt almost immediately upon administration.
Metabolism and Excretion
Adenosine is rapidly metabolized by cellular enzymes into inosine and other metabolites. The short half-life (approximately 10 seconds) limits systemic exposure and reduces the risk of prolonged side effects.
Special Considerations
Monitoring is crucial during administration, especially in patients with cardiovascular instability or those receiving concurrent medications that may affect heart rate or blood pressure.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

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Suitable for more than 50kg 
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We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

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2. Packaging photo
3. COA, MSDS, etc
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5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

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