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CAS No.:

15687-27-1

Grade:

Top Product

Content:

99%

Port:

QINGDAO

Brand:

Packaging:

5g,10g,50g or according to customer's detail requirement.

Sample Available:

Yes

Price valid (until):

2025-05-30

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Nanjing Huaman Import and Exp

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment

Average Lead Time:

5 days

Qualification:

Main Products:

Propylene glycol

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Product Description
Seller Information
Inquiry History

Description

Product Detail

Product Description

Celecoxib is a selective Cox-2(cyclooxygenase-2) inhibitor (IC50 of 40 nM). Celecoxib shows low sensitivity against Cox-1 (IC50 of 15 μM). Celecoxib shows an anti-proliferative effect on nasopharyngeal carcinoma (NPC) cell lines including HNE1 (IC50of 32.86 μM) and CNE1-LMP1 (IC50 of 61.31 μM).Celecoxib

Celecoxib is a COX-2 selective nonsteroidal anti-inflammatory drug (NSAID). It is used to treat the pain and inflammation of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain in adults, painful menstruation, and juvenile rheumatoid arthritis in people .

Celecoxibis a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain.

Product Detail

Celecoxib is a nonsteroidal antiinflammatory drug (NSAID) first launched as Celebrex in the US for the treatment of symptoms in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Celecoxib belongs to a new class of 1, 5-diarylpyrazoles and can be synthesized by heat-promoted heterocyclization of a trifiuoro-l,3-dione with appropriate. Celecoxib is a highly selective inhibitor of COX-2, the inducible form of cyclooxygenase expressed during inflammatory processes; it does not block the constitutive form COX-1, thus suppressing the gastric and intestinal toxicity of most non-selective NSAIDs. The potency ratio COX1/COX2 on purified human enzymes was about 400. In several in vivo models of acute and chronic inflammation, Celecoxib demonstrated potent antiinflammatory activity without affecting gastric or urinary prostaglandin PGE2. In several clinical studies performed with patients suffering from osteoarthritis or rheumatoid arthritis, Celecoxib was shown to be well tolerated and to relieve pain and inflammation more efficiently compared with other standard NSAIDs; the gastrointestinal safety profile was significantly better than that of other NSAIDs. Interestingly, Celecoxib was approved for another indication in patients with familial adenomatous polyposis (FAP). A six-month clinical trial demonstrated a 28% reduction in the number of colorectal polyps with Celecoxib, compared to a 5% reduction with placebo.

Name	Celecoxib
CAS NO.	169590-42-5
purity	99%
Standard packing material	Bag/Box
Appearance	White Powder
Shelf Life	2Years
storage condition and solubility	Inert atmosphere,Store in freezer, under -20°C;

Item	Standard	Result
Appearance	White or almost white crystalline powder	Almost white crystalline powder
Melting point	152-156°C	154.6-155.1°C
Specific optical rotation	-16° to -19°	-17.5°
Identification	(1)The retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation,as obtained in the assay.	Complies
	(2)UV absorption Max. at 266nm.	Complies
	(3)IR spectra is consistent with CRS.	Complies
PH	4.5-6.5	5.7
Chloride	0.02% max	<0.02%
Fluorides	4.8%min	4.9%
Related substances	Individual impurity not more than 0.5%	0.35%
Related substances	Total impurities not more than 2.0%	0.76%
Water	0.5% max	0.13%
Residue on ignition	0.1%max	0.06%
Heavy metals	Less than or egual to 20 millionths	Less than20 millionths

Function&Application:

Celecoxib is used for osteoarthritis, rheumatoid arthritis, acute pain, musculoskeletal pain, painful menstruation, ankylosing spondylitis, and to reduce the number of colon and rectal polyps in people with familial adenomatous polyposis.It may also be used in children with juvenile rheumatoid arthritis who are older than two years of age and weigh more than 10 kg (22 lb).

For postoperative pain, it is more or less equal to ibuprofen. For pain relief, it is similar to paracetamol (acetaminophen).And in osteoarthritis, acetaminophen is the first line treatment.In knee and hip osteoarthritis, acetaminophen may be ineffective.
Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.
Celecoxib is used to treat pain or inflammation caused by many conditions such as arthritis, ankylosing spondylitis, and menstrual pain.

Celecoxib is used for osteoarthritis, rheumatoid arthritis, acute pain, musculoskeletal pain, painful menstruation, ankylosing spondylitis, and to reduce the number of colon and rectal polyps in people with familial adenomatous polyposis.It may also be used in children with juvenile rheumatoid arthritis who are older than two years of age and weigh more than 10 kg (22 lb).

For postoperative pain, it is more or less equal to ibuprofen. For pain relief, it is similar to paracetamol (acetaminophen).And in osteoarthritis, acetaminophen is the first line treatment.In knee and hip osteoarthritis, acetaminophen may be ineffective.

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★ The company has been established for more than 10 years with rich export experience and experienced transportation team.

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1. By Express

------Suitable for under 50kg, Fast:3-7 days.

High cost; Door to door service. Easy to pick up the goods.

2. By Air

------Suitable for more than 50 kg, Fast:3-7 days,

High cost, airport to airport. professional broker needed.

3. By sea

------Suitable for more than 500kg. Slow: 5-45 days,

Low cost. Port to Port, professional broker needed.

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1. Any inquiries will be replied within 24 hours.

2. Dedication to quality, supply & service.

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4. OEM/ODM Available.

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ECHEMI Editorial Reference

Colourless, Crystalline SolidChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.Ibuprofen is a white, crystalline anti-infl ammatory drug used in numerous medications. It is the active ingredient marketed under various trade names including Advil, Motrin, and Nurofen. Ibuprofen is a nonsteroidal anti-infl ammatory drug (NSAID) used as a pain reliever (analgesic), fever reducer (antipyretic), and infl
Solid
Ibuprofen is a monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a cyclooxygenase 2 inhibitor, a cyclooxygenase 1 inhibitor, an antipyretic, a xenobiotic, an environmental contaminant, a radical scavenger, a drug allergen and a geroprotector. It derives from a propionic acid. It is a conjugate acid of an ibuprofen(1-).|Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 1974. It was the first available over-the-counter NSAID. On the available products, ibuprofen is administered as a racemic mixture. Once administered, the R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo by the activity of the alpha-methylacyl-CoA racemase. In particular, it is generally proposed that the S-enantiomer is capable of eliciting stronger pharmacological activity than the R-enantiomer.|Ibuprofen is a commonly used nonsteroidal antiinflammatory (NSAID) drug which is available both by prescription and over-the-counter. Ibuprofen is considered to be among the safest NSAIDs and is generally well tolerated but can, nevertheless, rarely cause clinically apparent and serious acute liver injury.|A nonsteroidal anti-inflammatory agent with analgesic properties used in the treatment of RHEUMATISM and ARTHRITIS.

Certificates

Basic Info

Product Name:

Ibuprofen

Other Name:

Benzeneacetic acid,α-methyl-4-(2-methylpropyl)-;Hydratropic acid,p-isobutyl-;α-Methyl-4-(2-methylpropyl)benzeneacetic acid;Ibuprofen;p-Isobutylhydratropic acid;2-(p-Isobutylphenyl)propionic acid;Brufen;RD 13621;Motrin;IP 82;4-Isobutylhydratropic acid;α-(4-Isobutylphenyl)propionic acid;2-(4-Isobutylphenyl)propanoic acid;Ibufen;Paduden;Nuprin;p-Isobutyl-2-phenylpropionic acid;Nurofen;Unipron;Rufin;Advil;2-(4′-Isobutylphenyl)propionic acid;Proflex;(±)-α-Methyl-4-(2-methylpropyl)benzeneacetic acid;(±)-Ibuprofen;(RS)-Ibuprofen;(±)-Ibuprophen;(±)-2-(p-Isobutylphenyl)propionic acid;dl-Ibuprofen;(4-Isobutylphenyl)-α-methylacetic acid;4-Isobutyl-α-methylphenylacetic acid;Dolgit;Librofem;Ranofen;Noritis;Bloom;Carol;Panafen;Lidifen;Fenspan;Provon;Pantrop;Ibu-Tab;Andran;Brufanic;Roidenin;Rupan;Mynosedin;Ibuprohm;Perofen;Atril 300;Ibren;Ibufug;Mensoton;Cobo;Rafen;Irfen;Tabalon 400;Brufort;Optifen;Dolofen;Fenbid;Anco;Anafen;Isodol;Ibu-slow;Ibugen;Emflam;Nobfelon;Napacetin;Ibuflamar;Act 3;Zafen;Anflagen;Adex 200;Brufen Retard;Balkaprofen;Drin;Ostofen;Betaprofen;Inflam;Urem;Nagifen-D;Inza;Inabrin;Ibugesic;Lamidon;Antiflam;Algofen;Dolocyl;Ibupirac;Alaxan;Prontalgin;Dolmaral;Lopane;Ibosure;Artril;Buburone;Syntofene;Stelar (pharmaceutical);Proartinal;Emflam 200;Dibufen;Ifen;Brofen;Ipren;Brufen 400;Ostarin;Novogent;Codral Period Pain;Paxofen;Donjust B;Dorival;Tarein;Nobafon;Ibuprocin;Am-Fam 400;139466-08-3;58560-75-1

CAS No.:

15687-27-1

Molecular Formula:

C13H18O2

InChIKeys:

InChIKey=HEFNNWSXXWATRW-UHFFFAOYSA-N

Molecular Weight:

206.28100

Exact Mass:

206.28

EC Number:

239-784-6

NSC Number:

757073|256857

DSSTox ID:

DTXSID5020732

Color/Form:

Colorless, crystalline stable solid

ATC Code:

HScode:

2924299090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

37.30000

XLogP3:

3.5

Appearance:

Solid

Density:

0.9181 g/cm³ @ Temp: 30 °C

Melting Point:

75-77 °C

Boiling Point:

141-142 °C @ Press: 100 Torr

Flash Point:

216.7ºC

Refractive Index:

1.5500 (estimate)

Water Solubility:

H2O: insoluble

Storage Conditions:

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Vapor Pressure:

0.000139mmHg at 25°C

Toxicity:

LD50 in male mice, rats (mg/kg): 495, 626 i.p.; 1255, 1050 orally (Orzalesi)

Odor:

Characteristic odor

PKA:

5.3None

Dissociation Constants:

5.3|pKa= 5.2|pKa = 4.91

Collision Cross Section:

144 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

See More Ibuprofen Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H320 Causes eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Preparations containing ibuprofen tablets should be stored in well closed, light resistant containers at 15-30 deg C.

See More Ibuprofen Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Propylene glycol

Location:
No .41 Optics Valley Avenue, East Lake High-tech Development Zone, Wuhan ,China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment

Average lead Time:
5 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2024

Nanjing Huaman Import and Export Co., Ltd was established in 2024 with strong research and development capabilities and superb synthesis technology, as well as advanced quality control measures. Effectively promote the joint venture and cooperation with the major enterprises, manufacturers, with the idea of industrial development to serve the society and the majority of users. We always adhere to the market demand as the orientation, constantly synthesizing new high-tech chemical products , mainly exported to the United States, Europe, India, South Africa, Nigeria and other countries and regions, has a wealth of export experience, to ensure transportation safety, can let each customer as soon as possible to safely receive the goods.

Inquiry History

13 Inquiries

Country	Product	Purchase Quantity	Date Posted
South Korea	Top Quality 99.7% Purity Antipyretic Analgesia Ibuprofen Powder 15687-27-1	100 G	Nov 8, 2023
China	Ibuprofen	40000 KG	Sep 25, 2025
India	IBUPROFEN IP	20 MT	Jun 21, 2025
India	IBUPROFEN API.	1000.00 KG	Mar 27, 2025
Pakistan	ibuprofen	1000.00 KG	Dec 31, 2024
Pakistan	ibuprofen	2.5 KG	Oct 29, 2024
United Kingdom	ibuprofen acid	500 G	Nov 24, 2025
India	Ibuprofen	5 TON	Dec 31, 2024
United States	Ibuprofen	1000 KG	Dec 30, 2024
India	Ibuprofen	17 MT	Sep 14, 2024
Bangladesh	Ibuprofen powder BP grade	4500 KG	Aug 20, 2026
India	IBUPROFEN	100.00 KG	Jun 16, 2025
Turkey	IBUPROFEN	1000 KG	Apr 2, 2024

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supply High Quality 99% Purity Ibuprofen 15687-27-1 for good price

Product Description

Seller Information

Inquiry History

Function&Application:

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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