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High Quality Imatinib Mesylate CAS 220127-57-1 Powder Fast Shipping Good Price

Name: High Quality Imatinib Mesylate CAS 220127-57-1 Powder Fast Shipping Good Price
Brand: HyperChem
SKU: pr2501151260
Price: 70 USD
Availability: InStock

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CAS No.:

220127-57-1

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/Bag

Price valid (until):

2025-02-15

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Imatinib Mesylate
CAS number	220127-57-1
Synonym	CGP 57148; CGP57148; CGP-57148; CGP57148B; CGP-57148B;
Description	Capecitabine is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand.
Structure
Molecular Formula	C30H35N7O4S
Molecular Weight	589.71 g/mol
Appearance	White Powder
Quality Standard	99%
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 2~8 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag, Bottle
Commercial package	Aluminium Tin
Origin	China

Imatinib Mesylate More Info

Imatinib mesylate is a targeted therapy medication primarily used in the treatment of certain types of cancer. Here are some detailed aspects of Imatinib mesylate:

Mechanism of Action

Imatinib mesylate is a tyrosine kinase inhibitor that specifically targets the BCR-ABL fusion protein, which is produced by a genetic abnormality known as the Philadelphia chromosome, commonly associated with chronic myeloid leukemia (CML) and some acute lymphoblastic leukemias. By inhibiting this protein, Imatinib blocks the signaling pathways that promote cell growth and division, thereby inducing apoptosis (programmed cell death) in the malignant cells. Additionally, it inhibits other tyrosine kinases, such as c-KIT and platelet-derived growth factor receptor (PDGFR), which contribute to its effectiveness in treating gastrointestinal stromal tumors (GISTs).

Indications

Imatinib mesylate is indicated for the treatment of:

Chronic Myeloid Leukemia (CML) : Particularly in patients with the Philadelphia chromosome-positive CML in chronic phase, accelerated phase, or blast crisis.

Acute Lymphoblastic Leukemia (ALL) : In cases that are Philadelphia chromosome-positive.

Gastrointestinal Stromal Tumors (GISTs) : For unresectable or metastatic tumors that are positive for c-KIT mutations.

Dermatofibrosarcoma Protuberans (DFSP) : As a treatment for unresectable or metastatic cases.

Administration

Imatinib mesylate is typically administered orally in the form of tablets, with the dosage depending on the specific condition being treated, the patient’s response, and tolerability. It is usually taken once daily with food to enhance absorption and minimize gastrointestinal side effects.

Side Effects

Common side effects of Imatinib mesylate may include:

Gastrointestinal issues: Such as nausea, vomiting, diarrhea, and abdominal pain.

Edema: Swelling due to fluid retention, commonly in the face and limbs.

Fatigue: Many patients report feeling unusually tired or weak.

Dermatological reactions: Skin rash or itching may occur.

Hematological effects: Such as neutropenia (low white blood cell count) and thrombocytopenia (low platelet count), leading to an increased risk of infections and bleeding.

Considerations

Patients should be monitored closely for potential side effects, particularly those involving blood counts and liver function.

In cases of renal or hepatic impairment, dosage adjustments may be necessary as these conditions can impact the metabolism and clearance of the drug.

Drug interactions: Imatinib may interact with other medications, so it is essential to inform healthcare providers of all current medications.

Conclusion

Imatinib mesylate is a pivotal therapeutic option for patients with specific types of leukemia and tumors characterized by tyrosine kinase abnormalities. Its targeted action minimizes harm to normal cells compared to traditional chemotherapy, significantly improving the quality of life and survival rates in patients with these conditions. As with all cancer treatments, it should be administered under the guidance of healthcare professionals, with careful monitoring and management of side effects.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service

By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders:
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

ECHEMI Editorial Reference

Imatinib Mesylate is a tyrosine kinases inhibitor that inhibits c-Kit, Bcr-Abl, and PDGFR (IC50=100 nM) tyrosine kinases.
Imatinib methanesulfonate is a methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours. It has a role as an antineoplastic agent, an apoptosis inducer, a tyrosine kinase inhibitor and an anticoronaviral agent. It contains an imatinib.|Imatinib Mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Inhibition of the bcr-abl TK results in decreased proliferation and enhanced apoptosis in malignant cells of Philadelphia-positive (Ph+) hematological malignancies such as CML and ALL; effects on c-kit TK activity inhibit mast-cell and cellular proliferation in those diseases overexpressing c-kit, such as mastocytosis and gastrointestinal stromal tumor (GIST).|A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors.

Basic Info

Product Name:

Imatinib mesylate

Other Name:

Benzamide,4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-,methanesulfonate (1:1);Benzamide,4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-,monomethanesulfonate;Imatinib mesilate;Imatinib mesylate;CGP 57148B;STI 571;Glivec;Gleevac;Gleevec;1-Methyl-4-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)piperazine methanesulfonate;Mitinab;ST 571

CAS No.:

220127-57-1

Molecular Formula:

C29H31N7O.CH4O3S

InChIKeys:

InChIKey=YLMAHDNUQAMNNX-UHFFFAOYSA-N

Molecular Weight:

589.70800

Exact Mass:

589.24700

EC Number:

606-892-3

UNII:

8A1O1M485B

NSC Number:

716051

DSSTox ID:

DTXSID9040502

NCI Thesaurus Code:

C1687

Color/Form:

White to off white to brownish or yellowish tinged crystalline powder

ATC Code:

L01XE01

HScode:

2933990090

Categories:

Other Chemical Drugs

Characteristics

PSA:

149.03000

XLogP3:

5.19690

Appearance:

white crystalline powder .

Density:

0.858 g/mL at 25 °C(lit.)

Melting Point:

146-148 °C

Boiling Point:

754.9ºC at 760 mmHg

Flash Point:

410.3ºC

Refractive Index:

n20/D 1.401(lit.)

Water Solubility:

In water, >100 g/l @ pH 4.2; 49 mg/l @ pH 7.4

Experimental Properties:

Lipophilic at pH 7.4|Molecular weight: 493.60; melting point: 211-213 °C; pKa1: 8.07; pKa2: 3.73; pKa3: 2.56; pKa 4: 1.52 /Imatinib/

See More Imatinib mesylate Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Imatinib mesylate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

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Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Bangladesh	Imatinib Mesylate	2100 G	Oct 27, 2025

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High Quality Imatinib Mesylate CAS 220127-57-1 Powder Fast Shipping Good Price

Product Description

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