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Anticancer API 99% TYRA-300/TYRA 300/Dabogratinib CAS:2800223-30-5 for R&D buy - image1

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Anticancer API 99% TYRA-300/TYRA 300/Dabogratinib CAS:2800223-30-5 for R&D

Name: Anticancer API 99% TYRA-300/TYRA 300/Dabogratinib CAS:2800223-30-5 for R&D
Brand: HyperChem
SKU: pr2604022368
Price: 1500 USD
Availability: InStock

COA TDS 243 Inquiries

Unit Price:

$1500-1800/G FOB

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CAS No.:

2800223-30-5

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1g/bag, 20g/bag, 50g/bags or other quantities

Sample Available:

Yes

Price valid (until):

2028-01-31

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Details
Seller Information
Inquiry History

Description

Name	Dabogratinib
CAS number	2800223-30-5
Synonym	TYRA-300 Dabogratinib 2800223-30-5 A1AV2 dabogratinib
Related APIs #	Baricitinib - CAS: 1187594-09-7 Tofacitinib - CAS : 477600-75-2 Fedratinib - CAS : 936091-14-4 Upadacitinib - CAS : 1310726-60-3 Oclacitinib - CAS: 1208319-26-9
Description	Detailed Uses & Applications (Comprehensive Overview) Dabogratinib (TYRA-300) is an investigational, oral, small-molecule inhibitor specifically designed to target the fibroblast growth factor receptor 3 (FGFR3) with high selectivity over other FGFR isoforms (FGFR1, 2, 4). Its development is strategically focused on two distinct therapeutic areas where FGFR3 dysregulation plays a central pathogenic role: oncology (specifically urothelial cancers) and skeletal dysplasias (achondroplasia). The drug's value proposition lies in its FGFR3 isoform selectivity, which aims to provide clinical efficacy while minimizing the off-target toxicities (e.g., hyperphosphatemia, retinal detachment) commonly associated with first-generation pan-FGFR inhibitors. 1. Oncology Application: FGFR3-Altered Urothelial Carcinoma In the oncology setting, TYRA-300 is being developed as a precision medicine for tumors harboring FGFR3 alterations (mutations or fusions), which are frequent drivers in urothelial carcinoma (bladder cancer). The primary mechanism here is antagonism of oncogenic signaling. Mechanism of Action in Cancer: In FGFR3-altered cancers, the receptor is constitutively active, leading to uncontrolled proliferation and survival of tumor cells. Dabogratinib binds to the ATP-binding pocket of FGFR3, inhibiting its kinase activity. This blockade suppresses downstream signaling pathways (MAPK, PI3K/AKT, STAT), resulting in cell cycle arrest and apoptosis (programmed cell death) in preclinical models. Its activity extends to certain gatekeeper mutations (e.g., FGFR3 V555M), which often confer resistance to other FGFR inhibitors, positioning it as a potential therapy for resistant disease. Clinical Context & Unmet Need: Approximately 15-20% of muscle-invasive and metastatic urothelial carcinomas harbor FGFR3 alterations. While Erdafitinib (a pan-FGFR inhibitor) is approved, its use is limited by toxicity from FGFR1 inhibition. TYRA-300's selectivity aims to offer a safer, more targeted option. It is under evaluation in multiple Phase 2 trials: SURF301: For metastatic urothelial carcinoma (mUC). SURF302: For FGFR3-altered, intermediate-risk, non-muscle invasive bladder cancer (NMIBC). SURF303: For low-grade upper tract urothelial carcinoma (UTUC). Therapeutic Goal: To provide a potent, well-tolerated oral treatment that can be used in the metastatic setting and potentially in earlier stages of disease to delay or prevent progression, improving progression-free survival (PFS) and quality of life. 2. Rare Disease Application: Achondroplasia (Skeletal Dysplasia) In a groundbreaking repurposing of its mechanism, TYRA-300 is also being studied as a potential treatment for achondroplasia, the most common form of dwarfism. In this context, the drug's role is modulation of physiological bone growth rather than cytotoxicity. Mechanism of Action in Achondroplasia: Achondroplasia is caused by a gain-of-function mutation (G380R) in FGFR3. This hyperactive receptor acts as a negative regulator of endochondral bone growth at the growth plate, inhibiting chondrocyte proliferation and differentiation, leading to shortened long bones. Dabogratinib, by inhibiting the overactive FGFR3, aims to "release the brake" on bone growth. It seeks to restore a more normal pace of chondrogenesis, thereby increasing annual growth velocity and improving final adult height potential. 3. Potential Broader Applications Preclinical data suggests potential utility in other FGFR3-driven skeletal dysplasias (e.g., hypochondroplasia, thanatophoric dysplasia) and other solid tumors where FGFR3 fusions are implicated (e.g., glioblastoma, squamous cell lung cancer), though these remain exploratory.
Molecular Formula	C ₂₅ H ₂₄ Cl ₂ N ₆ O ₃S
Molecular Weight	559.47 g/mol
Appearance	White or almost white powder
Quality Standard	Enterprise standard; 99.99%
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0-28℃ for short term (days to weeks) or 0-8℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Double plastic bags inside, fiber drum outside, any quantity available.
Commercial package	Aluminium Tin, Fiber drum
Origin	China

FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

ECHEMI Editorial Reference

Dabogratinib(TYRA-300) , a 3-pyridylindazole analog, is a reversible and selective inhibitor of FGFR3 with an IC50 of 11 nM in Ba/F3 cells. It also exhibit potent activity in human bladder cancer cell lines harboring FGFR3 activating fusions or mutations.

Certificates

Basic Info

Product Name:

TYRA-300

Other Name:

TYRA-300;2,6-Diazaspiro[3.3]heptane, 2-[5-[5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]-2-pyridinyl]-6-(methylsulfonyl)-;(R)-5-(1-(3,5-Dichloropyridin-4-yl)ethoxy)-3-(6-(6-(methylsulfonyl)-2,6-diazaspiro[3.3]heptan-2-yl)pyridin-3-yl)-1H-indazole;TYRA-300(Dabogratinib);Tyra-300 99% Shaanxi Dideu Medichem

CAS No.:

2800223-30-5

Molecular Formula:

C25H24Cl2N6O3S

InChIKeys:

JOAFWIHZEBKYQK-OAHLLOKOSA-N

Molecular Weight:

559.47

EC Number:

610-261-8

Categories:

Circulatory System Drugs

Characteristics

Density:

1.58±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

Boiling Point:

791.2±70.0 °C(predicted)

PKA:

11.87±0.40(predicted)

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

243 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Tyra-300 CAS 2800223-30-5	9 G	Jul 8, 2026
United States	TYRA-300 CAS 2800223-30-5	8 G	Jul 14, 2026
Australia	Wholesale TYRA-300 Powder CAS 2800223-30-5 with Best Price	1 G	Sep 21, 2026
United States	Wholesale TYRA-300 Powder CAS 2800223-30-5 with Best Price	5 G	Sep 11, 2026
United States	High Quality TYRA-300 99% powder 2800223-30-5 Shaanxi Dideu Medichem Co.Ltd	8 G	Aug 2, 2026
Germany	TYRA-300	5 G	Aug 1, 2026
Portugal	TYRA 300	100 G	Oct 22, 2026
Germany	TYRA-300	5 MG	Oct 19, 2026
United States	Tyra-300	1 G	Oct 18, 2026
United Kingdom	Tyra 300	1 G	Oct 17, 2026
United Kingdom	Tyra 300	1 MT	Oct 16, 2026
Taiwan, China	Tyra 300	3 G	Oct 16, 2026
Norway	Tyra 300	6 G	Oct 15, 2026
United States	Tyra 300	1 G	Oct 14, 2026
Hungary	Tyra 300	3 G	Oct 12, 2026
United States	tyra-300	1 G	Oct 12, 2026
United States	dabogratinib	10 MG	Oct 12, 2026
Canada	TYRA-300	500 G	Oct 12, 2026
United States	dabogratinib Tyra 300-2800223-30-5	5 G	Oct 12, 2026
Spain	Tyra 300	1 MT	Oct 9, 2026

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Anticancer API 99% TYRA-300/TYRA 300/Dabogratinib CAS:2800223-30-5 for R&D

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