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API Avatrombopag maleate

Name: API Avatrombopag maleate
Brand: Hyper Chem
SKU: pr2501161112
Price: 70 USD
Availability: InStock

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CAS No.:

677007-74-8

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2025-02-16

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information

Description

Name	Avatrombopag maleate
CAS number	677007-74-8
Synonym	AKR501; AKR 501; AKR-501; YM477; YM-477; YM 477; AS 1670542; AS1670542; AS-1670542; E5501; E-5501; E 5501; Avatrombopag; Avatrombopag maleate.
Related CAS	677007-74-8 (maleate) 570406-98-3 (free base) 570403-17-7 (HCl)
Description	Avatrombopag, also known as AKR-501, YM477, AS 1670542 or E5501, is a novel orally-active thrombopoietin (TPO) receptor agonist. AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501 may be useful in the treatment of patients with thrombocytopenia. Avatrombopag was first approved in 2018.
Structure
Molecular Formula	C₃₃H₃₈Cl₂N₆O₇S₂
Molecular Weight	765.720
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Avatrombopag maleate More Info

1. General information

Avatrombopag maleate is a thrombopoietin (TPO) receptor agonist. It is designed to stimulate the production of platelets. The chemical formula of avatrombopag maleate is C₂₉H₂₅N₅O₄S · C₄H₄O₄.

2. Mechanism of action

It works by binding to the TPO receptor on the surface of megakaryocytes (the bone marrow cells that produce platelets). By activating this receptor, it initiates a signaling cascade that promotes the growth and differentiation of megakaryocytes, ultimately leading to an increase in platelet production. This mechanism is beneficial for patients with thrombocytopenia (a low platelet count). For example, in patients with chronic liver disease who are about to undergo a procedure, a low platelet count can increase the risk of bleeding. Avatrombopag maleate can help to increase the platelet count and reduce this risk.

3. Medical uses

It is used for the treatment of thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a medical or dental procedure. Thrombocytopenia is a common complication in patients with liver diseases such as cirrhosis. These patients often have an increased risk of bleeding during invasive procedures. Avatrombopag maleate can help to raise the platelet count to a level that is considered safe for the procedure.

4. Dosage and administration

The dosage of avatrombopag maleate usually depends on the patient's condition and the expected platelet response. It is typically taken orally, which is a convenient administration route for patients. The treatment duration may vary depending on the individual patient's needs and the type of procedure they are undergoing.

5. Side effects

Common side effects may include headache, fatigue, and nausea. In some cases, it may also cause an increase in liver enzymes. More serious but less common side effects could potentially include thromboembolic events (formation of blood clots that can travel and block blood vessels), so careful monitoring of patients is necessary during treatment.

Certificates

Basic Info

Product Name:

Avatrombopag maleate

Other Name:

(Z)-but-2-enedioic acid,1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid;

CAS No.:

677007-74-8

Molecular Formula:

C33H38Cl2N6O7S2

InChIKeys:

MISPBGHDNZYFNM-BTJKTKAUSA-N

Molecular Weight:

765.72700

Exact Mass:

764.1620453

UNII:

GDW7M2P1IS

NCI Thesaurus Code:

C142941

ATC Code:

B02BX

Categories:

Other Chemical Drugs

Characteristics

PSA:

236.47000

XLogP3:

6.74510

See More Avatrombopag maleate Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Avatrombopag maleate Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

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Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.
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