Avatrombopag maleate CAS 677007-74-8, Purity: 98%

Avatrombopag maleate More Info

1. General information

Avatrombopag maleate is a thrombopoietin (TPO) receptor agonist. It is designed to stimulate the production of platelets. The chemical formula of avatrombopag maleate is C₂₉H₂₅N₅O₄S · C₄H₄O₄.

2. Mechanism of action

It works by binding to the TPO receptor on the surface of megakaryocytes (the bone marrow cells that produce platelets). By activating this receptor, it initiates a signaling cascade that promotes the growth and differentiation of megakaryocytes, ultimately leading to an increase in platelet production. This mechanism is beneficial for patients with thrombocytopenia (a low platelet count). For example, in patients with chronic liver disease who are about to undergo a procedure, a low platelet count can increase the risk of bleeding. Avatrombopag maleate can help to increase the platelet count and reduce this risk.

3. Medical uses

It is used for the treatment of thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a medical or dental procedure. Thrombocytopenia is a common complication in patients with liver diseases such as cirrhosis. These patients often have an increased risk of bleeding during invasive procedures. Avatrombopag maleate can help to raise the platelet count to a level that is considered safe for the procedure.

4. Dosage and administration

The dosage of avatrombopag maleate usually depends on the patient's condition and the expected platelet response. It is typically taken orally, which is a convenient administration route for patients. The treatment duration may vary depending on the individual patient's needs and the type of procedure they are undergoing.

5. Side effects

Common side effects may include headache, fatigue, and nausea. In some cases, it may also cause an increase in liver enzymes. More serious but less common side effects could potentially include thromboembolic events (formation of blood clots that can travel and block blood vessels), so careful monitoring of patients is necessary during treatment.