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Avatrombopag maleate

Avatrombopag maleate structure

CAS No:
677007-74-8
Formula:
C33H38Cl2N6O7S2
Chemical Name:
Avatrombopag maleate
Synonyms:
(Z)-but-2-enedioic acid,1-[3-chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid;
Categories:
Organic Chemistry > Carboxylic Acids and Derivatives

Description

Avatrombopag Maleate is the maleate salt form of avatrombopag, an orally available platelet thrombopoietin receptor (TPOR; MPL) agonist, with potential megakaryopoiesis stimulating activity. Upon administration, avatrombopag binds to and stimulates TPOR, which may lead to the proliferation and differentiation of megakaryocytes from bone marrow progenitor cells. This increases the production of platelets and may prevent chemotherapy-induced thrombocytopenia (CIT). TPOR is a cytokine receptor and member of the hematopoietin receptor superfamily.

Avatrombopag maleate Basic Attributes

Molecular Weight：

765.72700

Exact Mass：

764.1620453

UNII：

GDW7M2P1IS

NCI Thesaurus Code：

C142941

ATC Code：

B02BX

Characteristics

PSA：

236.47000

XLogP3：

6.74510

Drug Information

Drug Indication：

Doptelet is indicated for the treatment of severe thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo an invasive procedure.Doptelet is indicated for the treatment of primary chronic immune thrombocytopenia (ITP) in adult patients who are refractory to other treatments (e.g. corticosteroids, immunoglobulins).|Treatment of Idiopathic Thrombocytopenia Purpura (ITP), Treatment of Thrombocytopenic Purpura Secondary to Liver Disease

Avatrombopag maleate Use and Manufacturing

Use Classification：

Human drugs -> Doptelet -> EMA Drug Category|Antihemorrhagics -> Human pharmacotherapeutic group|Human Drugs -> EU pediatric investigation plans|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:765.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:9
Exact Mass:764.1620453
Monoisotopic Mass:764.1620453
Topological Polar Surface Area:233
Heavy Atom Count:50
Complexity:1050
Defined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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