Factory Supply High Quality USP/EP Standard Hydroxypropyl-β-Cyclodextrin CAS 94035-02-6

Hydroxypropyl-β-Cyclodextrin CAS 94035-02-6

Product Description:

Hydroxypropyl - β - cyclodextrin has lower toxicity than its parent cyclodextrin, is non-toxic when taken orally, and has low hemolysis. It has been proven through extensive animal and clinical experiments to be suitable for oral and injection use, and has been approved by the US Food and Drug Administration for use in food and pharmaceuticals.
The semi lethal dose of general pharmaceutical grade hydroxypropyl - β - cyclodextrin for white mice is greater than 2000mg/kg. Daily oral administration of 4400mg/kg and repeated 90 day toxicity experiments have shown no effect on the health of white mice. The stimulation experiment on the skin and eyes of experimental rabbits showed no stimulation on the skin and eyes of the test subjects. Sensitivity experiments showed that it had no sensitization to the skin of experimental pigs. Hydroxypropyl - β - cyclodextrin has shown good tolerance in animal experiments such as rats, mice, and dogs, especially when taken orally, showing only limited toxicity. In short-term experiments, the subjects only experienced very slight physiological changes, while in relatively long-term (three months) experiments, the subjects showed minor hematological changes but no histopathological changes. During intravenous administration, histopathological changes were observed in the lungs, liver, and kidneys, but these changes were reversible and quickly recovered after discontinuation without any adverse effects on the body. Carcinogenicity studies have shown an increased likelihood of tumors developing in the pancreas and intestines of experimental rats, but this is considered a rat specific phenomenon. Experiments on rats and rabbits have shown that hydroxypropyl - β - cyclodextrin has no effect on embryos. In clinical trials, the human body has a good tolerance to hydroxypropyl - β - cyclodextrin, and the main discomfort is diarrhea. Data shows that hydroxypropyl - β - cyclodextrin has no effect on human kidney function.

Product Function:

Hydroxypropyl-B-cyclodextrin is mainly used in food manufacturing to eliminate odor, improve the stability of flavor essence and pigment, and enhance emulsifying capacity and moisture resistance. Improving the taste of food is a good stabilizer and flavoring agent for the pharmaceutical, food, and cosmetics manufacturing industries. In medicine, it can improve drug solubility and bioavailability, increase the efficacy of drugs or reduce the dosage, adjust or control the release rate of drugs, reduce drug toxicity and side effects, enhance drug stability, mainly used in oral liquids, with the highest safety.