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Andrographolide | Andrographis Paniculata Extract | CAS 5508-58-7, diterpene lactone for anti-inflammatory & immune support buy - large image1

Andrographolide | Andrographis Paniculata Extract | CAS 5508-58-7, diterpene lactone for anti-inflammatory & immune support buy - image1

Andrographolide | Andrographis Paniculata Extract | CAS 5508-58-7, diterpene lactone for anti-inflammatory & immune support

Name: Andrographolide | Andrographis Paniculata Extract | CAS 5508-58-7, diterpene lactone for anti-inflammatory & immune support
Brand: PREMIUM INGREDIENT
SKU: pr2502181084
Price: 10 USD
Availability: InStock

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CAS No.:

5508-58-7

Grade:

Food Grade

Content:

98%

Port:

shanghai

Brand:

PREMIUM INGREDIENT

Packaging:

25kgs/drum

Price valid (until):

2025-03-18

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PREMIUM INGREDIENT CO.,LTD

Company Type:

Manufactory

Location:

United Kingdom

Payment Terms:

TT against copy of documents,L/C

Average Lead Time:

80 days

Qualification:

Main Products:

l-lysine monohydrochloride,dl-methionine,n-acetyl-l-cysteine,l-methionine,glycine,l-cysteine hcl monohydrate

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Product Description
Seller Information
Inquiry History

Description

Basic Information

Item	Details
Product Name	Andrographolide
Synonyms	Andrographis paniculata extract
CAS No.	5508-58-7
Main Source	Andrographis paniculata (Burm.f.) Nees
Plant Part Used	Aerial parts / Leaves and tender stems
Product Type	High-purity labdane diterpenoid monomer
Main Active Component	Andrographolide
Specification	Andrographolide 98% HPLC
Content Range	10%, 20%, 98%
Product Color	White crystalline powder
Identification	HPLC, UV, IR
Extraction Method	Isolation and purification from Andrographis paniculata

Product Overview

Andrographolide is extracted from the dried aerial parts of Andrographis paniculata . It’s the key diterpenoid lactone active compound, is standardized as the marker ingredient. This botanical ingredient is well researched for anti-inflammatory and immune-modulating properties, supporting respiratory comfort and body’s natural defense. It is supplied as brown fine powder in mainstream 10% and 20% andrographolide grades, the most widely traded specifications for dietary supplement and functional food manufacturers, with good formulation compatibility for nutritional and skincare applications.

Compounding Characteristics

Andrographolide is a botanical powder derived from dried aerial parts of Andrographis paniculata. It has a characteristic bitter taste, supplied in 10% and 20% mainstream bulk grades with stable batch-to-batch consistency. It can be combined with other botanical ingredients such as echinacea, elderberry and licorice for multi-functional immune wellness formulas, and should be stored in sealed containers in cool, dry conditions away from moisture, high temperature and strong light to preserve stability.

Main Functions

1.Anti-Inflammatory Activity: Andrographolide is widely studied for inflammatory pathway modulation and is one of the primary reasons this ingredient is used in supplement formulations.

2.Immune Support: It is commonly formulated into immune support and seasonal wellness products, especially in Asian herbal supplement markets.

3.Antioxidant Activity: The diterpenoid structure contributes to free radical scavenging and oxidative stress support.

4.Hepatoprotective Activity: Andrographolide is used in liver support formulas as a botanical active ingredient.

5.Cardiovascular Protection Research: It is also studied for vascular health and cardiovascular protection, though this remains more research-oriented.

Applications

1.Dietary Supplements : High-purity andrographolide 98% is mainly used in anti-inflammatory support, immune support, liver support and antioxidant capsules/tablets.

2.Functional Food & Beverage: Applied in herbal wellness drinks, botanical powder blends and functional food ingredients.

3. Pharmaceutical Intermediates: Used as a high-purity reference ingredient or intermediate in pharmaceutical development.

4.Cosmetic Raw Materials: Applied in antioxidant and soothing skincare formulations.

Packaging & Storage

Packing: 25kg/drum

Storage: Store in cool, dry, dark and ventilated place

Shelf Life: 24 months under standard sealed storage

Product name	Andrographis Paniculata P.E.
Latin Name	Andrographis paniculata ( Burm.f. ) Nees
Appearance	Brown or White Fine Powder
Product Specification	Andrographolide5%-98%
Loss on drying	NMT5.0%
Heavy metals	NMT10ppm
Acid insoluble Ash	NMT5.0%
CAS No	5508-58-7
Part used	whole herb or leaf
Test Method	HPLC/TLC
Particle Size	80 Meshes

ECHEMI Editorial Reference

Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation.

Certificates

Basic Info

Product Name:

Andrographolide

Other Name:

2(3H)-Furanone,3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-,(3E,4S)-;5β,9βH,10α-Labda-8(20),12-dien-16-oic acid,3α,14,15,18-tetrahydroxy-,γ-lactone;2(3H)-Furanone,3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-,[1R-[1α[E(S*)],4aβ,5α,6α,8aα]]-;Andrographis;(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone;Andrographolide;Andrographolid;3-dehydroandrographolide or 19-dehydroandrographolide? p. 1388;Andrographiside aglycon;101060-34-8;5953-53-7

CAS No.:

5508-58-7

Molecular Formula:

C20H30O5

InChIKeys:

InChIKey=BOJKULTULYSRAS-OTESTREVSA-N

Molecular Weight:

350.44900

Exact Mass:

350.45

EC Number:

226-852-5

HScode:

29322980

Categories:

Plant Extracts

Characteristics

PSA:

86.99000

XLogP3:

2.2

Appearance:

powder

Density:

1.2317 g/cm³ @ Temp: 21 °C

Melting Point:

218 °C (decomp)

Boiling Point:

557.3ºC at 760 mmHg

Flash Point:

195.5±23.6 °C

Refractive Index:

1.567

Storage Conditions:

Keep tightly closed. Store in a cool dry place.

See More Andrographolide Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Andrographolide Safety Data Sheet 

Seller Information

Business Type: Manufactory
Main Products: l-lysine monohydrochloride,dl-methionine,n-acetyl-l-cysteine,l-methionine,glycine,l-cysteine hcl monohydrate
Location: dongsheng road
Payment Terms: TT against copy of documents,L/C
Average lead Time: 80 days
Total Annual Revenue: $5 million-$10 million
Total Employees: 5-10
Year of Establishment: 2015

Premium Ingredient specializes in supplying and distributing food & feed amino acids, food additives and functional ingredients for more than a decade.

Our food additives portfolio covers phosphates, acidulants, preservatives, sweeteners, thickeners and leavening agents.

Our functional ingredients include vitamins, mineral products, botanical extracts, nutraceutical ingredients, functional fibers & bulking agents.

We serve over 100 clients across food & beverage, dietary supplement, sports nutrition, personal care, pharmaceutical and animal feed sectors, with products exported to dozens of countries worldwide. All our goods are sourced from top-tier Chinese manufacturers with proven expertise and complete management systems.

◆Amino Acids	◆ phosphates	◆ acidulants
◆ preservatives	◆ sweeteners	◆ functional fiber&bulking agent
◆ thickeners	◆ Leavening agents	◆ mineral products
◆ Botanical extracts	◆ vitamins	◆ nutritional products

Backed by over 10 years of industry experience, we provide one-stop-shop solutions combining high-grade products, prompt communication, on-time delivery and real-time market intelligence. Thanks to our long-term deep-rooted partnerships with source manufacturers, we can guarantee sufficient inventory, stable pricing and fast shipment.

Our third-party certifications include ISO9001, ISO14001, HACCP, HALAL, KOSHER, GMP, FAMI-QS and more. You can count on Premium Ingredient as your trusted global raw material supplier.

------------------------------------- Mission------------------------------------

Acting as a bridge between reliable Chinese manufacturers and global buyers, we carefully select partner factories with mature production capabilities and sound management systems. We deliver not only premium-quality raw materials, but also value-added services including market trend updates, supply chain risk alerts, product formulation consultation, consolidated sample shipment and full document support for import compliance. We timely forward overseas customers’ requirements to our partner factories to support product upgrading and achieve mutual growth.

-------------------------------------Our Quality------------------------------------

Our Quality

As a professional ingredient supplier, we do not operate manufacturing facilities. Instead, we build robust quality‑assurance workflows across our whole supply chain to safeguard consistent product performance for every shipment

Strict Supplier Due‑Diligence

Before entering any partnership, we carry out on-site factory visits and assess industry reputation, followed by multi-stage qualification reviews. We validate production qualifications, export track records, quality management systems and complete certification packages. New suppliers must pass sample evaluation, and only fully vetted top-tier factories are admitted to our approved supplier pool

Batch‑by‑batch Document Verification

For every order, we cross‑check factory‑issued test documents against agreed specifications including FCC, USP, EP, AJI, CP or your customized requirements. We will not forward documents to customers until key indicators are fully aligned with specifications. This step avoids inconsistent or mismatched documentation common in raw‑material trade.

Independent Third‑party Testing Coordination

Upon client request, we can arrange independent laboratory inspections from recognized third‑party institutions. We manage sample delivery, test protocol communication and report follow‑up to support your market compliance needs.

Quality Closure & Continuous Improvement

We keep traceable records for all delivered batches. If any quality concern arises, we act as your single point‑of‑contact to trace root causes with source factories, drive corrective actions and deliver practical resolution plans. Client feedback is systematically collected to optimize our supplier management and document‑review procedures.

We provide a comprehensive set of compliance documents to support your import and registration work. Our available documentation includes but is not limited to:

★ ISO Certification ★ Halal Certificate

★ Kosher Certificate ★ IP certificate

★ Haccp certificate ★ Allergens with Glutens

★ GRAS Statement ★ HACCP Program

★ BSE/TSE Statement ★ Certificate of Analysis

★ Country of Origin Certificate ★ Material Safety Data Sheet

★ Flow Chart (product processing) ★ Food Grade Certificate

★ Nutritional Information ★ GMO Statement

★ Specification Sheet

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Thailand	andrographolide	1 KG	Jun 26, 2024
India	andrographolidae	1 KG	Jun 25, 2026

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