Andrographolide
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Andrographolide
structure -
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CAS No:
5508-58-7
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Formula:
C20H30O5
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Chemical Name:
Andrographolide
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Synonyms:
2(3H)-Furanone,3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-,(3E,4S)-;5β,9βH,10α-Labda-8(20),12-dien-16-oic acid,3α,14,15,18-tetrahydroxy-,γ-lactone;2(3H)-Furanone,3-[2-[decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-,[1R-[1α[E(S*)],4aβ,5α,6α,8aα]]-;Andrographis;(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone;Andrographolide;Andrographolid;3-dehydroandrographolide or 19-dehydroandrographolide? p. 1388;Andrographiside aglycon;101060-34-8;5953-53-7
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CAS No:
Description
Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation.
Characteristics
86.99000
2.2
powder
1.2317 g/cm3 @ Temp: 21 °C
218 °C (decomp)
557.3ºC at 760 mmHg
195.5±23.6 °C
1.567
Keep tightly closed. Store in a cool dry place.
Safety Information
NONH for all modes of transport
3
R20/21/22
S22-S24/25
LU3490750
Xn
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
Drug Function and Efficacy
Has anti-inflammatory, antibacterial, choleretic and analgesic effects
Registered Holders
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Sichuan Wenlong Pharmaceutical Co., Ltd.
Active
China
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Sichuan PROVINCE YUXIN Pharmaceutical Co., Ltd.
Active
China
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Chengdu Tiantai Mountain Pharmaceutical Co., Ltd.
Active
China
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