Low price 4-[3-Chloro-4-(cyclopropylaminocarbonyl)aminophenoxy]- 417716-92-8

Name:Suki

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Email: suki@hnchenchi.com

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Paclitaxel is a monomeric diterpene compound extracted from the bark of the natural plant Taxus genus. It is a complex secondary metabolite and the only drug known to date that can promote microtubule polymerization and stabilize polymerized microtubules. Isotope tracing shows that paclitaxel only binds to polymerized microtubules and does not react with unpolymerized tubulin dimers. After cells come into contact with paclitaxel Chemicalbook, a large number of microtubules will accumulate in the cells. The accumulation of these microtubules interferes with various functions of the cells, especially stops cell division in the mitotic phase, blocking the normal division of cells. Through II-III clinical studies, paclitaxel is mainly suitable for ovarian cancer and breast cancer, and also has certain therapeutic effects on lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma, and brain tumors

Indications: It has good effects in treating ovarian cancer and platinum-resistant refractory ovarian cancer and breast cancer, and has good prospects in treating prostate cancer, head and neck cancer, esophageal cancer, germ cell tumors, endometrial cancer, lymphoma, bladder cancer, upper gastrointestinal cancer, small cell and non-small cell lung cancer.

Side effects
Adverse reactions to paclitaxel usually include allergic reactions, bone marrow suppression, neurotoxicity, cardiovascular toxicity, joint and muscle pain, gastrointestinal reactions, liver toxicity, hair loss, etc. The unique adverse reaction of the injection is the allergic reaction to the excipient polyoxyethylated castor oil.

Application

 1. Anti-tumor drug. Used to treat metastatic breast cancer and metastatic ovarian cancer. Broad-spectrum anti-tumor herbal medicine;

2. Effective anti-tumor drug for the treatment of ovarian cancer, breast cancer and other diseases; binds to the N-terminal region of β-tubulin, promotes the formation of highly stable microtubules, resists depolymerization, prevents normal cell division and captures in the G2/M phase of the cell cycle;

3. An anti-microtubule drug that inhibits depolymerization by promoting tubulin polymerization, maintains tubulin stability, and inhibits cell mitosis. Acting on human endothelial cells, the IC50 is 0.1pM.

Function

1.Taxol is a mitotic inhibitor drup used in the treatment of cancer.
2. Isolated the compound from the bark of the Pacific yew tree, Taxus brevifolia, and noted its antitumor activity in a broad range of rodent tumors.
3. Taxol has since become an effective tool of doctors who treat patients with lung, ovarian, breast cancer, and advanced forms of Kaposi's sarcoma.
4.Taxol is also used for the prevention of restenosis (recurrent narrowing) of coronary stents; locally delivered to the wall of the coronary artery, a paclitaxel coating limits the growth of neointima (scar tissue) within stents.

A: After purchasing the products from our factory, we have A professional technical team and after-sales team to serve you and solve all your problems in the future
Q2: Can I get some samples?
A: Yes, we can provide samples, but the customer will pay the freight.
Q3: How do I start paying?
Payment can be made by Bitcoin,T/T, wire transfer paypal
Q4: How to confirm product quality before placing an order?
A: You can get free samples of some products. You just have to pay the shipping fee or arrange for the sample to be sent to us by express.You can send us your product specifications and requirements and we will produce products according to your requirements.
Q5: What is your MOQ?
A: The minimum quantity we can order is 1 kilo.But usually we can accept a smaller quantity, say 100g, at the cost of 100% sample charge.
Q6: Shipping Time?
A: We ship the parcel out in 3-7 days and offer tracking No.. Shipping time is different to different country. Please consult.

Company Profile

Jinan Silk Road Trading Co., Ltd.  Henan Province, which has developed transportation. We are engaged in the development, marketing and sales of intermediates, Peptides, Ste roids, Sterol, chemicals and other products.

Our products enjoy good reputation both at home and abroad. Our trade partners are around the world, mainly in America,Europe,Australia,South East Asia ,Middle East and South Africa. In order to serve customers well, the company has established special technical department and after-sale service department. We will make careful reply if you get any question.

The company with all the employees will constantly purse excellent quality, perfect brand and our image, and adheres to our spirit of honesty, diligence, seeking truth and progress and insists on business philosophy of quality as life and service as soul. We will satisfy market demands by top products and better service, and will welcome market challenge forever.

 

Our advantage

1. Own your own chemical plant

2. Rich professional production experience

3. Sample free and in stock, delivery

4. Price, quality and service, we care about all your concerns

5. Timely reply Keep in touch to save your time

6. Easy customs clearance, we have all these controlsAll very good

7. Dedicated researchers customize it for you.