Tirzepatide (tirzepatide) is a novel glucagon-like peptide-1 receptor (GLP-1) and glucose-dependent insulin-stimulating polypeptide (GIP, also known as gastric inhibitory polypeptide) double-receptor agonist administered once a week. Both GLP-1 and GIP belong to incretin, which is a Chemicalbook polypeptide secreted by the gastrointestinal mucosa. The former can bind to the receptors on the islet cells and stimulate insulin secretion, thus producing hypoglycemic effect, delaying gastric emptying and suppressing appetite, thus controlling body weight. The latter has the function of inhibiting gastric acid, pepsin secretion, stimulating insulin release, inhibiting gastric peristalsis and emptying, and can supplement the effect of GLP-1 receptor agonist.

Retatrutide is an investigational single molecule that activates the body's receptors for three hormones - glucagon, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1), and is being studied for the treatment of obesity.
It employs a triple-agonist (triple-G) mechanism of action. In addition to being a GLP-1RA, it also targets gastric inhibitory polypeptide receptor (GIPR), and glucagon receptor (GCGR). This has consequently shown increased efficacy benefits in clinical trials, superior to those seen with W, which facilitates around -15% body weight loss.

Applications:

• *Promotes metabolic flexibility and homeostasis
  *Helps regulate mitochondrial energy
  *Protects against age and diet-dependent insuli resistance and obesity
  *Helps with weight loss
  *Promotes resistance to metabolic stress
  *Improves exercise capacity
  *Helps prevent osteoporosis
  *Improves glucose regulation
  *Promote fatty acid metabolism in the liver

CERTIFICATE  OF  ANALYSIS
Product name:  Retatrutide
CAS: 910463-68-2

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