98-96-4pyrazinamide
98-96-4
Pharmaceutical Grade
99%
qingdao
25kg/drum
2026-10-26
API,Antibiotics,Anti cancer category
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferencePyrazinamide is a pyrazine that is used therapeutically as an antitubercular agent.Target: AntibacterialPyrazinamide is a prodrug that stops the growth of Mycobacterium tuberculosis. Pyrazinoic acid was thought to inhibit the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids although this has been discounted. It was also suggested that the accumulation of pyrazinoic acid disrupts membrane potential and interferes with energy production, nece
Pyrazinamide is a white powder. Sublimes from 318°F. (NTP, 1992)|Solid
Pyrazinamide is a white powder. Sublimes from 318°F. (NTP, 1992)|Pyrazinecarboxamide is a monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis. It has a role as an antitubercular agent and a prodrug. It is a member of pyrazines, a N-acylammonia and a monocarboxylic acid amide.|A pyrazine that is used therapeutically as an antitubercular agent.|Pyrazinamide is an Antimycobacterial.|Pyrazinamide is a first line antituberculosis medication, but is used only in combination with other antituberculosis medications such as isoniazid or rifampin. Pyrazinamide is associated with transient and asymptomatic elevations in serum aminotransferase levels and is a well known cause of clinically apparent, acute liver injury that can be severe and even fatal.|Pyrazinamide is a synthetic pyrazinoic acid amide derivative with bactericidal property. Pyrazinamide is particularly active against slowly multiplying intracellular bacilli (unaffected by other drugs) by an unknown mechanism of action. Its bactericidal action is dependent upon the presence of bacterial pyrazinamidase, which removes the amide group to produce active pyrazinoic acid. Pyrazinamide is an important component of multidrug therapy for tuberculosis. (NCI04)Basic Info-
Product Name:
Pyrazinamide
Other Name:2-Pyrazinecarboxamide;Pyrazinecarboxamide;D 50;MK 56;Aldinamid;2-Carbamylpyrazine;Eprazin;Pyrazinamide;Pyrazine carboxylamide;Pyrazinoic acid amide;Tebrazid;Aldinamide;Zinamide;Unipyranamide;Pyrazinecarboxylic acid amide;Pirazinamid;Novamid;Pirazimida;Farmizina;Pyrafat;2-Carboxamidopyrazine;α-Pyrazinamide;2-(Aminocarbonyl)pyrazine;NSC 14911;Pyrazide;Isopas;Rifafour e-200;Rifcin;Rozide;Pyramizade
CAS No.:98-96-4
Molecular Formula:C5H5N3O
InChIKeys:InChIKey=IPEHBUMCGVEMRF-UHFFFAOYSA-N
Molecular Weight:123.11
Exact Mass:123.11
EC Number:202-717-6
UNII:2KNI5N06TI
NSC Number:757304|14911
DSSTox ID:DTXSID9021215
NCI Thesaurus Code:C29395
Color/Form:Crystals|Crystals from water or alcohol|Crystals from water or ethyl alcohol
ATC Code:J04AK01|J - Antiinfectives for systemic use
HScode:2934999090
Categories:
Characteristics-
PSA:
68.9
XLogP3:-0.6
Appearance:White Crystalline Powder or Needles
Density:1.4475 g/cm3
Melting Point:192 °C
Boiling Point:SUB (NTP, 1992)
Flash Point:>110°(230°F)
Refractive Index:1.648
Water Solubility:H2O: soluble 50mg/mL
Storage Conditions:-20°C Freezer
Toxicity:LD50 intraperitoneal in mouse: 1680mg/kg
PH:Aqueous solutions are neutral
PKA:-0.5None
Dissociation Constants:pKa= 0.5
Collision Cross Section:122.8 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Begins to sublime at 60 °C
Air and Water Reactions:Water soluble.
Reactive Group:Amides and Imides
Reactivity Profile:PYRAZINAMIDE is an amide derivative. Incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. May react with active metals or nitrides to produce flammable gaseous hydrogen. Incompatible with strongly oxidizing acids, peroxides, and hydroperoxides.
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 1, Dermal
Skin irritation, Category 2
Acute toxicity - Category 1, Inhalation
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H310 Fatal in contact with skin
H315 Causes skin irritation
H330 Fatal if inhaled
Precautionary statement(s) Prevention P262 Do not get in eyes, on skin, or on clothing.
P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P320 Specific treatment is urgent (see ... on this label).
Storage P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Pyrazinamide tablets should be stored in well-closed containers at a temperature less than 40 deg C, preferably between 15-30 deg C.
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Seller Information
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Business Type:
Trader
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Main Products:
API,Antibiotics,Anti cancer category
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Location:
12A02-9, Union Building, Building 1, No. 216 Tongchuan Road, Licang District, Qingdao City, Shandong Province
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
15
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Total Annual Revenue:
$25 million-$50 million
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Total Employees:
201-300
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Year of Establishment:
2024
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Certifications:
Hazardous Chemicals Business License,Supplier Agreement
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
