99% BP USP GMP Pyrazinamide

Pyrazinamide More Info

Pyrazinamide is a synthetic pyrazine analog of nicotinamide, first developed in the 1950s during intensive research for more effective tuberculosis treatments. Its discovery was pivotal because it exhibited a unique sterilizing activity against Mycobacterium tuberculosis that was not found in other first-line drugs. Specifically, it is particularly effective against dormant bacilli residing within the acidic environment of macrophages, a bacterial population that other TB drugs often cannot eradicate. Its exact mechanism of action is not fully elucidated but is believed to involve the disruption of mycolic acid synthesis and membrane energy production by the bacterial enzyme pyrazinamidase, which converts the prodrug into its active form, pyrazinoic acid. This targeted action within specific physiological niches makes it an indispensable component of modern anti-tuberculosis therapy.

Uses and Applications

The primary and almost exclusive application of Pyrazinamide is as a first-line bactericidal agent in the combination chemotherapy of active tuberculosis (TB). It is never used as a monotherapy due to the rapid development of bacterial resistance. Its role is crucial in the initial, intensive two-month phase of standard short-course therapy, where it is combined with isoniazid, rifampicin, and ethambutol. This combination drastically shortens the total required treatment duration from 9-12 months to just 6 months. By targeting persisting bacilli, it plays a key role in preventing relapse, making it a cornerstone of the global Directly Observed Treatment, Short-course (DOTS) strategy endorsed by the World Health Organization (WHO). Its use is generally confined to the treatment of tuberculosis and is not applied for other bacterial infections.

Application Market

The market for Pyrazinamide is almost entirely driven by global public health initiatives aimed at controlling and eradicating tuberculosis. It is classified as an essential medicine by the WHO. The market is dominated by generic manufacturers, and a significant portion of the supply is procured in bulk by international organizations (e.g., The Global Drug Facility) and national governments for public health programs, particularly in high-TB-burden countries in Asia and Africa. It is formulated almost exclusively as oral tablets, often included in fixed-dose combination (FDC) products with other anti-TB drugs to improve patient adherence. While available in private markets, its distribution is heavily weighted towards public health supply chains and non-profit treatment programs.

Important Considerations

Pyrazinamide use requires careful medical supervision due to its potential for significant adverse effects. The most serious concern is dose-related hepatotoxicity (liver damage), necessitating baseline and periodic monitoring of liver function tests. It can also induce hyperuricemia (elevated uric acid), which may precipitate gouty arthritis in susceptible individuals. Other common side effects include arthralgia, nausea, and anorexia. It is contraindicated in patients with severe liver damage or a history of acute gout. In an industrial setting, handling the pure active pharmaceutical ingredient (API) requires the use of personal protective equipment (PPE) to prevent dust inhalation and minimize skin contact. It is for use only in finished, prescribed dosage forms as part of a comprehensive TB treatment regimen.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.