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High quality 99% purity Taltirelin Fast delivery

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Unit Price:

$20/UNIT FOB

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CAS No.:

103300-74-9

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shenzhen

Brand:

XSY

Packaging:

vials,foil bag,drums

Sample Available:

Yes

Price valid (until):

2029-11-29

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Shandong Xinshunyue Energy Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/A,O/A,100% TT in advance

Qualification:

Main Products:

Retatrutide,Tirzepatide,Semaglutide,GHK-CU,MOTS-C,TB500

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Product Description
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Inquiry History

Description

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Description

cas	103300-74-9
Name	Taltirelin
Synonyms	Taltirelin
MF	C17H23N7O5
Purity	99%
Application	Taltirelin(TA0910) is an orally active TRH analogue that binds to TRH receptors in the mouse brain.

Product Introduction

Taltirelin is the first approved oral thyrotropin-releasing hormone (TRH) in the world. In addition to endocrine effects, it can also exert certain central nervous system (CNS) effects, including improving motor activity, antagonizing Reserpine-induced hypothermia and antagonism of sleep.

Spinocerebellar ataxias (SCAs), formerly known as autosomal dominant ataxias, are a group of chronic degenerative diseases of the central nervous system with ataxia and dysmetria as the main clinical manifestations. Before September 2000, thyrotropin-releasing hormone (TRH) injection was the only drug used to treat this type of disease.

Tatirelin is a structurally modified drug of TRH. Pharmacological studies have shown that this product has strong and long-lasting multiple effects on the CNS through brain TRH receptors. The excitatory effect of this product on the CNS is 10 to 100 times stronger than that of TRH, and the duration of action is about 8 times longer than that of TRH. The affinity of this product to TRH receptor is about 1/11 of that of TRH, so the endocrine effect of this product is weaker than that of TRH, but this product is more stable than TRH in vivo.

In addition, the effect of this product on the release of thyrotropin (TSH) is 1/6-1/11 of that of TRH. The release of TSH is regulated by a strong negative feedback system including thyroid hormone and has a strong effect on the central nervous system. But at the same time, its hormone-like effect is small, so there are fewer side effects. Adverse reactions were mainly digestive system reactions, including vomiting, nausea and stomach upset. All adverse reactions were mild to moderate and disappeared during treatment and/or after drug withdrawal.

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Our service

1.We supply Peptides, APIs & Intermediates and so on to satisfy your needs;
2. We will reply you for your inquiry in 24 hours;
3. Strictly on selecting raw materials . Our Q&C team will inspect every product quality strictly before delivery

4. Reasonable & competitive price, fast lead time ;

5. After delivery, we will track the products for you once every two days, until you get the products. When you got the goods, if you have any questions about the problem, contact with us, we will offer the solve way for you ;

6. 100% safe delivery, guaranteed delivery .

Packaging

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Delivery

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FAQ

Q:Can i get free sample ? A: Yes, most product we can send you small free sample, you just need to pay the shipping cost .

Q:Which payment method you accept? A: We accept bank transfer,T/T,PayPal,Credit card etc. and more bigger order we accept L/C at sight

Q: Can i get tracking number after shipment ? and how long does the shipping take? A: After shipment we will offer you tracking no and tell you the website to track the package, usually the shipping time is 3-7days,but for some customers have no ability to declare customs, we use special line route to ship the package, it will take 10-12days to arrive,make sure 100% delivery

Q: How can you guarantee the quality ? A: All products we can supply you test report &you can also send our product to the third party to do test, if it is fake,we will full refund you.

Q: How to store it? A: If it hasn't been opened, just put it in cool dry place, if it is opened, you may put it in cold storage for 2-5 degree condition.

Q: How to order this product? A: You can click "contact Supplier" , or write an email to my inbox, and send us a inquiry, leave your number if possible, we will contact with you as soon as possible, then we can talk order details.

Q: How about the delivery time? A: Shipped within 48 hours after payment is received.Small orders are shipped via express door-to-door.The goods arrive in about7-10 days.

Q：ls cash on delivery ? A:in most cases,we don't support cash on delivery.

Q: How much is the commodity? A: As we all know, the price of chemicals is not fixed, but fluctuates with the market. You need to contact me to get the latest product price, we promise to give you the most favorable price.

Q:About the after-sale service? A:After purchasing the products from our Company, we have a professional technical team and after-sales team to serve you and solve all your problems in the future.

Company infor

Shandong Xinshunyue was established in 2024 with strong research and development capabilities and superb synthesis technology, as well as advanced quality control measures. Effectively promote the joint venture and cooperation with the major enterprises, manufacturers, with the idea of industrial development to serve the society and the majority of users. We always adhere to the market demand as the orientation, constantly synthesizing new high-tech chemical products and medical intermediates, mainly exported to the United States, Europe, India, South Africa, Nigeria and other countries and regions, has a wealth of export experience, to ensure transportation safety, can let each customer as soon as possible to safely receive the goods.

ECHEMI Editorial Reference

Taltirelin was marketed in Japan for the treatment of neurodegenerative diseases, in particular the improvement of ataxia due to spino-cerebellar degeneration (SCD); it is the first orally-active drug in this indication. This synthetic thyrotropin-releasing hormone (TRH) analog is prepared by condensation of (S)-1-methyl-4,5-dihydroorotic acid with L-histidyl-Lprolinamide. It was shown that the S-configuration for all 3 chiral centers is crucial for CNS activity. Taltirelin is a potent agon
Taltirelin is an oligopeptide comprising of (4S)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxylic acid, L-histidine and L-prolinamide joined in sequence by peptide linkages. It is a thyrotropin-releasing hormone (TRH) analog. Its tetrahydrate form is approved in Japan for the treatment of spinal muscular atrophy. It has a role as a nootropic agent, a neuroprotective agent and an analgesic.

Certificates

Basic Info

Product Name:

Taltirelin

Other Name:

L-Prolinamide,(4S)-hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-;L-Prolinamide,N-[(hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl)carbonyl]-L-histidyl-,(S)-;(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-L-prolinamide;TA 0910;Taltirelin;Ceredist

CAS No.:

103300-74-9

Molecular Formula:

C17H23N7O5

InChIKeys:

InChIKey=LQZAIAZUDWIVPM-SRVKXCTJSA-N

Molecular Weight:

405.41

Exact Mass:

405.41

UNII:

DOZ62MV6A5

DSSTox ID:

DTXSID0043763

Categories:

Polypeptide

Characteristics

PSA:

171

XLogP3:

-4.09

Density:

1.447±0.06 g/cm3(Predicted)

Melting Point:

72-75 °C

Refractive Index:

1.612

Storage Conditions:

Store at +4°C

Specific rotation:

25D -13.6° (c = 1 in water)

See More Taltirelin Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Taltirelin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Retatrutide,Tirzepatide,Semaglutide,GHK-CU,MOTS-C,TB500

Location:
zibo

Payment Terms:
TT against copy of documents,D/A,O/A,100% TT in advance

Total Employees:
5-10

Year of Establishment:
2025

CoAs a peptide manufacturer, our products include Retatrutide, Tirzepatide, semaglutide, etc. Our products are of good quality and high purity. Welcome to consult and place an order.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
United Kingdom	Taltirelin	1 G	Dec 29, 2023

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High quality 99% purity Taltirelin Fast delivery

Product Description

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