Caffeic Acid Extract CAS 331-39-5 Factory Supply Wholesale Bulk good Price 99% Caffeic Acid Powder

Caffeic Acid Extract CAS 331-39-5 Factory Supply Wholesale Bulk Best Price 99% Caffeic Acid Powder

What is caffeic acid?

Caffeic acid, an organic acid, can be safely used in cosmetics and has a wide range of antibacterial activities. Absorbs UV rays. A low concentration is an adjuvant that inhibits skin-type hair dyes, which is beneficial to enhance the intensity of the color.

Caffeic acid is an organic compound belonging to hydroxycinnamic acid and has two functional group structures:  hydroxyl group. Because caffeic acid is a key intermediate in the biosynthesis of lignin, one of the main components of plant biomass and its residues, it is widely present in various plants. It is soluble in hot water and , and slightly soluble in cold water.

Caffeic acid and its derivatives belong to the phenylpropionic acid class from the chemical structure point of view, and are synthesized from cinnamic acid as the precursor in terms of biogenic pathways. Such chemical components are widely distributed in the plant kingdom and are secondary metabolites formed during aerobic respiration of plants. Caffeic acid, ferulic acid and their derivatives chlorogenic acid and salvianolic acid are widely distributed in plant groups of traditional Chinese medicine resources and are important phenylpropanoid resource products in traditional Chinese medicine. For example, the traditional Chinese medicine cinnamon is rich in cinnamic acid, caffeic acid is one of the main active substances in dandelion, ferulic acid is the main component of various medicinal plants of the Apiaceae family, and chlorogenic acid mainly exists in medicinal plants of the Caprifoliaceae family. Among them, salvianolic acid components are mainly distributed in the traditional Chinese medicine Salvia miltiorrhiza. Erucinic acid has a high content in citrus plants such as rapeseed oil and lemons. Apples and hawthorns also contain caffeic acid derivatives such as chlorogenic acid. These natural  acids have a variety of physiological activities in the body and are very good drug lead compounds.

Caffeic acid is a compound found in a variety of anti-itching plants. Sabindra Pradhananga and others once reported in the Journal of European Pharmacology that it has extensive antipruritic effects. It has an anti-itching effect on itching caused by histamine etc., but it is not effective on itching caused by β-alanine.

What are the functions of the product?

1. Has a wide range of antibacterial activities, in vitro use effect is strong;

2. Low concentration can inhibit the activity of collagenase, caries prevention and skin anti-wrinkle effect

3. It has strong and broad-spectrum antioxidant activity, which can inhibit the generation of lipid peroxide;

4. The decrease and loss of filagin in the cortex may be the main cause of dry skin diseases such as atopic dermatitis, and the promotion of filagin production by caffeic acid shows that it has anti-inflammatory effects on the skin

5. Can also be used in whitening skin care products

6. It also has the function of absorbing ultraviolet light

Antiviral Activity

In recent years, studies have found that caffeic acid and its derivatives have very good anti-influenza virus and anti-HIV activities. Caffeic acid can inhibit the proliferation of influenza A virus and inhibit the spread of hepatitis C virus in the initial stage of hepatitis C virus infection. Caffeic acid phenethyl ester, a derivative of caffeic acid, is a natural substance discovered in recent years that has very obvious anti-HIV properties. In addition, lithospermic acid and salvianolic acid B have strong inhibitory activity against human immunodeficiency virus type I (HIV-I) integrase, with IC5 of 0.83 and 0.48 mol/L respectively, and are expected to become new natural drugs for the treatment of AIDS. In addition to anti-HIV virus, caffeic acid and quinic acid are condensed through an esterification reaction to form a series of compounds, collectively called caffeoylquinic acid, represented by chlorogenic acid components. This type of compound is widely present in Among plants such as Asteraceae, Fabaceae, Apiaceae, Convolvulaceae, etc., studies have found that this type of substance has very good antiviral activity and can effectively inhibit influenza viruses and hepatitis B viruses. Recent studies have found that chlorogenic acid and caffeic acid in forsythin can inhibit the proliferation of porcine transmissible gastroenteritis virus (TGEV) in porcine testicular cells (ST). Among them, caffeic acid can greatly reduce virus activity. It is expected to be developed into an antiviral drug.

Antibacterial, Anti-Infective

Caffeic acid and its derivatives are natural fungicides that can inhibit a variety of fungal and bacterial infections. Studies have shown that the antibacterial mechanism of caffeic acid components is related to its strong antioxidant properties. Salvianolic acid A in Salvia miltiorrhizae has good anti-inflammatory activity after ultrasonic extraction. The chlorogenic acid in Panax notoginseng, honeysuckle and Eucommia ulmoides has strong antibacterial activity and can be developed as a natural food preservative. Other studies have shown that the inhibitory effect of chlorogenic acid components on E. coli is due to the fact that these components can destroy the bacterial cell wall and membrane structure, leading to an increase in cell permeability, which in turn causes the leakage of cell contents and leads to cell apoptosis. .

Therapeutic Effect On Diabetes

In recent years, studies have shown that there is a certain connection between diabetes and oxidative stress, and the antioxidant effects of caffeic acid and its derivatives also play a positive role in the treatment of diabetes. Caffeic acid can reduce the absorption of glucose by endothelial cells, promote the decomposition of glycogen in the liver, and can also regulate insulin sensitivity by increasing glucose uptake in fat cells, thereby lowering blood sugar levels. Caffeic acid derivatives caffeic acid methyl ester (CAME) and caffeic acid ethyl ester (CAEE) and caffeic acid phenethyl ester (CAPE) can reduce the absorption of glucose by C2C12 cells. Sinapic acid can reduce high glucose-induced rat vascular smooth muscle cell proliferation and promote cell apoptosis by inhibiting PKC/P38 activation, and can be used for the prevention and treatment of diabetic complications. Salvianolic acid A can treat diabetes by activating AMPK and regulating mitochondrial pairing.

Multi-Target Anti-Itching

Caffeic acid is a  compound found in a variety of anti-itching plants. Sabindra Pradhananga and others once reported in the Journal of European Pharmacology that it has extensive antipruritic effects. It has an anti-itching effect on itching caused by histamine etc., but it is not effective on itching caused by β-alanine.

Caffeic Acid Inhibits Histamine-Induced Itching

Caffeic acid inhibits histamine-dependent itch. Coffee inhibits histamine-induced acute itching, and it also reduces the proportion of dorsal root ganglion neurons that respond to histamine in mice. Histamine-dependent itch is mainly mediated by the histamine receptor-TRPV1. The researchers expressed H1 receptors and TRPV1 only on HEK293T cells and found that 1mM caffeic acid can inhibit the changes in calcium ion concentration caused by histamine. Continue to express TRPV1 on HEK293T cells alone, and use capsaicin to induce changes in calcium ion concentration. Caffeic acid can also inhibit changes in calcium ion concentration in cells. Some studies have also found that caffeic acid inhibits itching caused by compound 48/80. The above indicates that caffeic acid reduces histamine-induced acute itching by inhibiting TRPV1.

Our advantage ：

★ The company has been established for more than 10 years with      rich export experience and experienced transportation team.

★ Awesome after sales.1 to 1 customer service to solve any problems from the beginning of the inquiry to the receipt of goods

★ Quality is guaranteed.

 Shipping Advise 1. By Express 

------Suitable for under 50kg, Fast:3-7 days.

High cost; Door to door service. Easy to pick up the goods.

2. By Air 

------Suitable for more than 50 kg, Fast:3-7 days,

High cost, airport to airport. professional broker needed.

3. By sea

------Suitable for more than 500kg. Slow: 5-45 days,

Low cost. Port to Port, professional broker needed.

                                                                                                            Service

1. Any inquiries will be replied within 24 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

4. OEM/ODM Available.

5. Reasonable & competitive price, fast lead time.

6. Sample is available for your evaluation & formulation development.

FAQ

1.How to get in touch with us?

You can chat with us by Trademanager,WhatsApp or simply giving us an email, a phone call. All our contacts information can be found from our website.

2.Are you a manufacturer or trade company?

We are a professional manufacturer.

3.Can I get a sample?

Yes, free sample can be provided, but shipping cost is covered by your side.

4.What's your MOQ?

It is based on the different product. Some are 1g while some are 1 kg. Please be free to consult our salesman.

5.When can I get the quotation?
We usually quote within 1 hours after we get your inquiry. If it's a urgent order you can call us or mention it in your email subject, and we can take it as priority.

6.Is there any discount?
Yes, some products are applied for discount, but it depends on the quantity.

7.Can you do OEM for me?
Yes,we accept OEM orders, just contact us and give us your requirement. We will offer you a reasonable price and make samples ASAP.