4 4 Diaminodiphenylsulfone CAS 80-08-0

80-08-0 – Standard

This product is 4,4 ‘-sulfonyl bis-aniline. Calculated as the dried product, the content of C12H12N202S shall not be less than 99.0%.

80-08-0 – Trait

• This product is white or off-white crystalline or crystalline powder; Odorless.
• This product is soluble in acetone, dissolved in methanol, slightly soluble in ethanol, almost insoluble in water; Dissolved in dilute hydrochloric acid.

melting point

The melting point of this product (General 0612) is 176~181°C.

80-08-0 – Differential diagnosis

1. take this product, add methanol to make a solution containing 5ug per lml, according to UV-visible spectrophotometry (General 0401) determination, there is a maximum absorption at a wavelength of 261nm and 296Nm. The absorbance was 0.35-0.38 and 0.59-0.62, respectively.
2. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 412).
3. This product shows the identification reaction of aromatic first amines (General rule 0301).

80-08-0 – Exam

Related substances

take this product, add methanol to dissolve and dilute to make a solution containing about 10 mg per 1 ml, as a test solution; Take appropriate amount of precision, solutions containing about 20UG and 100ug per 1 ml, respectively, were prepared by dilution with methanol as Control Solutions (1) and (2). According to the thin layer chromatography (General 0502) test, draw 10ul of each of the above three solutions, respectively, on the same silica gel G thin layer plate, with toluene-acetone (2:1) as the developing solvent, dry, spray with 0.5% sodium nitrite 0. A 1 mol/L hydrochloric acid solution was then sprayed with a 0.1% dihydrochloric acid solution of naphthyl ethylenediamine after several minutes. Test solution such as impurity spots, compared with the control solution (1) of the main spot, not deeper; If there is more than 1~2 points, should not be deep in the control solution (2) the main spot.

loss on drying

take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).

ignition residue

take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).

80-08-0 – Content determination

take this product about 0.25g, precision weighing, add water 30ml and hydrochloric acid solution (l-2)20ml, according to the permanent stop titration method (General rule 0701), with sodium nitrite titration solution (0.lmol/L) titration. Each l of sodium nitrite titration solution (0.1 mol/L) corresponds to 12.42mg of C12H12N202S.

80-08-0 – Category

anti-leprosy drugs.

80-08-0 – Storage

sealed storage.

80-08-0 – Dapsone tablets

This product contains dapsone (C12H12N202S) should be 93.0% to 107.0% of the label.

trait

This product is white or off-white.

identification

1. take this product, add methanol to make a solution containing about 5ug dapsone per 1 ml, filter, take the filtrate according to dapsone under the identification (1) test, showed the same results.
2. take an appropriate amount of fine powder of this product (approximately equivalent to dapsone O. 1G), 20ml of acetone was added, stirred, dapsone was dissolved, filtered, the filtrate was evaporated to dryness, and the residue showed the same reaction according to the identification (3) test under dapsone.

examination

• dissolution: according to the determination method of dissolution and release (General rule 0931, Method 1), the dissolution medium is 20ml of hydrochloric acid and water to 100 ml, and the rotation speed is rpm, operate according to the law, after 60 minutes, take the solution and filter, continue the filtrate (50mg specification) or take the continued filtrate accurately, A solution containing 50ug of dapsone per 1 mL (lOOmg specification) was prepared by quantitative dilution with dissolution medium as a test solution; An appropriate amount of dapsone reference was accurately weighed, the dissolution medium was added to dissolve and quantitatively dilute to prepare a solution containing about 50ug per 1 ml as a reference solution. Take 2ml of test solution and 2ml of reference solution respectively, put them in 25ml measuring flask, add 5ml of sodium hydroxide solution each, shake well, dilute with water to scale, shake well, the absorbance was measured at a wavelength of 0401 nm by ultraviolet-visible spectrophotometry (general), and the elution amount of each tablet was calculated. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
• others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).

Content determination

Take 20 tablets of this product, precise weighing, fine grinding, precise weighing to take an appropriate amount (equivalent to dapsone 0.25g), according to the method under the dapsone determination. Each 1 ml of sodium nitrite titration solution (0.1 mol/L) corresponds to 12.42mg of C12H12N202S.

category

Same as dapsone.

specification

(l)50mg (2)100mg

storage

sealed storage.