Ceramide AP, formerly known under the INCI name Ceramide 6 II, is the N-acylated sphingolipid consisting of Phytosphingosine having the D-erythro structure linked to an alpha-hydroxy saturated or unsaturated fatty acid.
Ceramid AP (AP stands for α-hydroxy-N-stearoylphytosphingosine) belongs to a larger group of ceramides that are naturally occurring, long chains of lipids (fats) in skin. To put it into perspective, skin’s general composition of ceramides is around 50% and of that, 16% of those ceramides are of the AP variety.
Decreased levels of ceramides have been shown to weaken the barrier, making skin more vulnerable to external stressors. More specifically, a decline in ceramide AP has been linked to skin conditions such as eczema and psoriasis.
Topical application of ceramide AP via skin care formulas can step in to help fill this gap and strengthen skin’s barrier against external stimuli. It contributes to the maintenance of skin elasticity and suppleness, promoting a healthy and youthful appearance. In general, ceramides work best when they’re combined with other replenishing ingredients like fatty acids and cholesterol. These lipid mixtures work in multiple ways to improve skin’s hydration, texture, and suppleness. Ceramides within skin also play a vital role in maintaining skin health since they signal other processes that keep things orderly.
The Cosmetic Ingredient Review Expert Panel’s 2020 assessment concluded that ceramide ingredients are safe in cosmetics in the present practices of use. Their survey data looked at personal care products containing concentrations between 0.00005-0.2% of ceramide AP.
| Items | Specifications |
| Synonyms | Ceramide 1 |
| Appearance | Powder |
| Grade | Cosmetic grade |
Product advantages
1.Functional raw materials in the field of daily chemicals
Ceramide NP can be used in skin care products, and has the functions of moisturizing, repairing, soothing, delaying aging, and alleviating atopic dermatitis.
2.Raw materials in the pharmaceutical field
Ceramide can be used as an important pharmaceutical raw material to treat acne in children and atopic dermatitis in people.
3.Functional raw materials in the food field
Oral administration of ceramides can help repair sebum membranes, reduce transepidermal water loss, increase skin moisture content, and improve dry skin.
Product efficacy
1.Moisturizing
As the most abundant component of intercellular lipids, ceramide plays a very important role in the skin，ceramide can prevent the loss of water and electrolytes, and has an moisturizing effect.
2.Delaying skin aging
As age increases, the ceramides and moisture present in the stratum corneum of human skin gradually decrease. Timely replenishment of ceramides can help delay skin aging and keep skin young.
3.Repairing skin barrier
According to the "brick wall theory" of the skin's natural barrier, keratinocytes are equivalent to bricks, and sebum membranes and intercellular lipids (ceramides, fatty acids, cholesterol, etc.) are cement, they stack up to form a "wall", thus forming a skin's natural protective barrier, ceramides are an important component in the brickwork structure and play a role in protecting the skin barrier. At the same time, ceramide and cell epidermal proteins can be connected through ester bonds to bond cells, preventing dryness, scaling, and scaly skin.
4.Reducing atopic dermatitis
For patients with atopic dermatitis, or patients with dermatitis caused by exposure to surfactants or organic solvents, ceramide NPs in the skin will be rapidly lost. The pathogenesis of atopic dermatitis is unclear and may be related to genetic factors, immune factors, skin barrier dysfunction, mental factors, lifestyle habits and environmental factors. Research shows that the primary mechanism of atopic dermatitis may be skin barrier dysfunction, especially the reduction of ceramide AP content in lipids, which is one of the main reasons for the impairment of skin barrier function. Timely replenishment of ceramides in the skin, especially ceramide NP, has important clinical significance in guiding medication for patients with atopic dermatitis.
5.Soothing skin
Ceramide maintains skin moisture by forming a network structure in the stratum corneum, improving dry skin, reducing scaling, and relieving redness, itching and other discomforts.
Product Application
1.Functional raw materials in the field of cosmetics
About us
Viablife is a hightech enterprise that is specialized in enzymatic synthesis and biomanufacturing of active pharmaceutical ingredients, fine chemicals, natural dyes, pharmaceutical intermediates, and food additives. Viablife has a world class R&D team that has a broad range of experience in fermentation, enzymes, metabolic engineering and synthetic biology. Viablife has its own manufacturing center Jiangxi Viablife Biopharmaceutical Co., Ltd., a wholly owned subsidiary located in Nanchang, China. The goal of Viablife is to develop green, efficient and cost effective biomanufacturing processes for industrially natural products.
