Name | 2-Hydroxypropyl-β-cyclodextrin |
CAS number | 128446-35-5 |
EINECS number | 420-920-1 |
Synonym | 2-Hydroxypropyl-β-cyclodextrin; Hydroxypropyl-β-Cyclodextrin; Hydroxypropyl Beta Cyclodextrin; Hydroxypropyl-beta-cyclodextrin; THPB; HPbCD; HP-beta-CD; HP-beta-CyD; VTS-270; HPbetaCD; HPbetaCyD; 2-hydroxypropyl-β-cyclodextrin; (2-Hydroxypropyl)-β-cyclodextrin |
Description | Hydroxypropyl-β-cyclodextrin is an ideal solubilizer for injection and drug excipient, which can improve the water solubility of insoluble drugs, increase the stability of drugs, improve the bioavailability of drugs, increase the efficacy of pharmaceuticals or reduce the dosage of medicines, adjust or control the release rate of the drug, reduce the toxic side effects of drugs.
1, in the field of food and spices, it can improve the stability and longevity of nutritional molecules, it can mask or correct the bad smell and taste of food nutritional molecules, it can improve the production process and product quality. The solubility of the product in water is very good, substitution degree 4 and above can be miscible with water in any proportion, in 50% ethanol and methanol can also be dissolved.
2, used as a stabilizer, emulsifier, deodorant, etc. in cosmetics raw materials, can reduce the stimulation of organic molecules in cosmetics on the skin and mucous membrane tissues, enhance the stability of the active ingredients to prevent the volatilization of nutrients, oxidation. It has a certain relative hygroscopicity.
3, in the pharmaceutical industry, due to the relative surface activity and hemolytic activity is relatively low and no irritation to the muscle, so it is an ideal injection solubilizer and drug excipient. |
Structure |  |
Molecular Formula | C63H112O42 |
Molecular Weight | 1541.54 g/mol |
Appearance | Solid powder |
Quality Standard | Enterprise Standard |
Assay | ≥98% |
Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
Storage Condition | Store in cool place. Keep container tightly closed in a dry and well ventilated place. |
Shelf Life | >2 years if stored properly |
Sample package | Aluminium foil bag |
Commercial package | Aluminium Tin, Fiber drum |
Origin | China |
Hydroxypropyl-β-cyclodextrin More Info
Hydroxypropyl-beta-cyclodextrin (HP-β-CD) is a chemically modified derivative of beta-cyclodextrin, a cyclic oligosaccharide composed of seven glucose units linked in a ring. It is widely used in pharmaceutical, food, and cosmetic industries as a solubilizing and stabilizing excipient.
Pharmaceutical Applications
Used as a solubilizer and stabilizer in oral, parenteral, ocular, nasal, and dermal drug formulations
Enhances bioavailability of poorly soluble active pharmaceutical ingredients (APIs) by forming reversible inclusion complexes
Reduces irritation and unpleasant tastes or odors of drugs by encapsulation
Prevents drug-drug and drug-excipient interactions within formulations
Approved for use in various marketed products including intravenous antifungals (e.g., itraconazole), nasal sprays, and topical formulations
Additional Uses and Research
Investigated for cholesterol and lipid extraction from cell membranes due to its hydrophobic cavity
Explored as a therapeutic agent in diseases involving lipid accumulation such as Niemann-Pick Type C disease
Studied for potential neuroprotective and anti-atherosclerotic effects in preclinical models
Safety and Toxicology
Considered generally recognized as safe (GRAS) by FDA and included in the European Pharmacopoeia
Well tolerated in humans and animals at doses up to several hundred mg/kg/day
Main adverse effects are mild and may include diarrhea or gastrointestinal discomfort at high oral doses
Caution advised in neonates, infants under 2 years, and patients with renal impairment due to reduced clearance and potential accumulation
Intravenous administration is generally safe but requires monitoring for renal function
Does not significantly affect fat-soluble vitamin absorption or metabolism
Pharmacokinetics
Poorly absorbed intact; primarily excreted unchanged via the kidneys
Rapid renal clearance in individuals with normal kidney function
Inclusion complexes dissociate in the gastrointestinal tract or systemic circulation, releasing the active drug
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