High Purity 99% White Crystalline Powder Meglumine CAS 6284-40-8 with good price

Meglumine More Info

Meglumine is a pharmacologically important organic compound primarily used in medicine as a solubilizing agent and as part of certain drug formulations.

Description and Uses

Chemical Nature: Meglumine is an organic base (N-methyl-D-glucamine) commonly used to adjust pH and improve solubility of acidic drugs in pharmaceutical formulations.
Pharmaceutical Applications: It is widely utilized as a pH-adjusting and solubilizing agent in both solid oral dosage forms and parenteral (injectable) formulations. By increasing the pH, meglumine helps dissolve active pharmaceutical ingredients (APIs) that ionize in acidic environments, thereby enhancing their absorption and bioavailability.
As a Drug Component: Meglumine forms salts with various drugs to improve their stability and solubility. For example, meglumine antimoniate is an antiprotozoal agent used to treat leishmaniasis, where meglumine acts as a carrier for pentavalent antimony.
Contrast Agents: Meglumine is also part of gadolinium-based contrast agents (e.g., gadoterate meglumine) used in magnetic resonance imaging (MRI) to enhance image quality.

Mechanism of Action

Meglumine itself is not pharmacologically active as a drug but serves as a vehicle or excipient to improve drug delivery and solubility.
In meglumine antimoniate, the active antimonial component acts against Leishmania parasites by inducing oxidative stress and DNA damage in the protozoa, although this can also cause oxidative damage in mammalian cells.

Routes of Administration

Meglumine-containing drugs are administered via various routes depending on the formulation:
Intramuscular or Intravenous Injection: For meglumine antimoniate in leishmaniasis treatment.
Topical or Oral: For formulations where meglumine is used as a solubilizing agent.
Intravenous: For contrast agents like gadoterate meglumine used in MRI.

Safety and Side Effects

Meglumine as an excipient is generally well tolerated.
Meglumine Antimoniate: Can cause side effects related to antimony toxicity including oxidative stress, DNA damage, and mutagenicity; treatment requires medical supervision.
Gadoterate Meglumine: Associated with rare but serious adverse effects such as nephrogenic systemic fibrosis (NSF) in patients with impaired kidney function and hypersensitivity reactions.
Common side effects related to meglumine-containing drugs depend on the active drug moiety rather than meglumine itself.

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FAQ

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We can send you a samll free sample, and you only need to pay for the shipping cost.

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For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

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Suitable for more than 50kg 
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For sample orders: 
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3. COA, MSDS, etc
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A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

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