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N-Methyl-D-glucamine

N-Methyl-D-glucamine structure

CAS No:
6284-40-8
Formula:
C7H17NO5
Chemical Name:
N-Methyl-D-glucamine
Synonyms:
D-Glucitol,1-deoxy-1-(methylamino)-;Glucitol,1-deoxy-1-(methylamino)-,D-;Sorbitol,1-deoxy-1-methylamino-;1-Deoxy-1-(methylamino)-D-glucitol;N-Methyl-D-glucamine;Meglumine;N-Methylglucamine;Methylglucamine;1-Deoxy-1-methylaminosorbitol;Meglumin;Methylglucamin;D-(-)-N-Methylglucamine;N-Methyl-D(-)-glucamine;N-Methylsorbitylamine;NSC 52907;NSC 7391;(2R,3R,4R,5S)-6-Methylaminohexane-1,2,3,4,5-pentaol;N,N-Methyl-2,7-octadienylglucamine;Emprove;133-52-8;31566-24-2;45081-44-5;50560-29-7;53418-31-8;61919-50-4;97780-33-1;131133-75-0;131337-57-0;168828-98-6;170034-45-4;184169-59-3;224432-61-5;768396-31-2;887770-59-4;901768-29-4;2230289-31-1
Categories:
Cosmetic Ingredient > Hair Conditioning

Description

Meglumine is an amino sugar derived from sorbitol.Target: OthersMeglumine is often used as an excipient in pharmaceuticals and in conjunction with iodinated compounds in contrast media such as diatrizoate meglumine and iodipamide meglumine.[1]

6-(methylamino)hexane-1,2,3,4,5-pentol is a hexose.|1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.

N-Methyl-D-glucamine Basic Attributes

Molecular Weight：

195.21

Exact Mass：

195.21

BRN：

385906

EC Number：

228-506-9

NSC Number：

52907|7391

HScode：

2922199090

Characteristics

PSA：

113

XLogP3：

-3.37

Appearance：

White to almost white Crystalline Powder

Density：

1.4±0.1 g/cm3

Melting Point：

128.5 °C

Boiling Point：

490.4±45.0 °C at 760 mmHg

Flash Point：

251.6±19.3 °C

Refractive Index：

-16.5 ° (C=2, H2O)

Water Solubility：

H2O: 0.1 g/mL, clear, colorless

Storage Conditions：

Store below +30°C.

Toxicity：

LD50 orally in Rabbit: > 5000 mg/kg

Specific rotation：

-16.5 º (c=10, H2O, on dry sub)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

24/25

RTECS Number：

LZ4295770

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P201, P202, P260, P263, P264, P270, P280, P281, P305+P351+P338, P308+P313, P310, P405, P501

Hazard Statements：

H318

Drug Information

MeSH：

Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)

MeSH Entry Terms：

Meglumine

N-Methyl-D-glucamine Use and Manufacturing

Uses

excipient in cosmetics and X-ray contrast media As a co-solvent and surfactant for contrast agents. Diagnostic drugs,biochemical research

Use Classification：

Cosmetics -> Hair conditioning

Computed Properties

Molecular Weight:195.21
XLogP3:-2.8
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:195.11067264
Monoisotopic Mass:195.11067264
Topological Polar Surface Area:113
Heavy Atom Count:13
Complexity:134
Undefined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Glucose

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Meglumine
Manufacturer	China Resources Double-Crane Pharmaceutical Co., Ltd.

Gastrografin Injection
Ingredients	The main ingredients and chemical names of this product are: Diatrizoate: 3,5-bis(acetylamino)-2,4,6-triiodobenzoic acid, dihydrate. Meglumine: 1-deoxy-1-(methylamino)-D-sorbitol.
Indication	Metformin therapy The use of intravascular X-ray contrast agents that are excreted by the kidneys can cause transient renal impairment. This can lead to lactic acidosis in patients taking biguanides. (As a precaution, biguanides should be discontinued 48 hours before contrast administration and should not be resumed until renal function has returned to normal at least 48 hours after contrast administration.) Patients receiving beta-blockers, especially those with bronchial asthma, may have exacerbated allergic reactions. In addition, it should be recognized that patients receiving beta-blockers may be insensitive to standard treatment of allergic reactions with beta-agonists. The incidence of late contrast reactions (such as fever, rash, flu-like symptoms, joint pain, and itching) is higher in patients receiving interleukin therapy. Interference with diagnostic examinations After the use of iodinated contrast agents, the ability of thyroid tissue to take up radioactive isotopes that diagnose thyroid abnormalities is reduced for up to 2 weeks, or even longer in some cases. Alcohol intoxication Acute or chronic alcohol intoxication can increase the permeability of the blood-brain barrier. This allows contrast agents to easily enter brain tissue, which may trigger central nervous system reactions. Alcoholics and drug addicts must be cautioned because of the possibility of a lowered seizure threshold.
Specifications	100ml:60g
Manufacturer	Shanghai Xudong Haipu Pharmaceutical Co., Ltd.

Meglumine

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Registered Holders

ANMOL CHEMICALS PRIVATE LTD

United States
Active
MERCK KGAA

Belgium
Active
Suzhou Jingye Medicine&Chemical Co., Ltd.

China
Active

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Guide of N-Methyl-D-glucamine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Material
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

N-Methyl-D-glucamine

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