Supply High Quality Levomefolate calcium CAS 151533-22-1 L-5-Methyltetrahydrofolate Calcium for Food Grade

Levomefolate calcium More Info

Levomefolate calcium, also known as calcium L-5-methyltetrahydrofolate, is the calcium salt of the biologically active form of folate. It plays a crucial role in various physiological processes, including DNA synthesis and the regulation of homocysteine levels. This compound is particularly important for individuals with certain metabolic disorders or those requiring supplementation during pregnancy.

Mechanism of Action

Levomefolate calcium functions primarily as a methyl donor in one-carbon metabolism, which is essential for various biochemical reactions. It facilitates the conversion of homocysteine to methionine through a reaction catalyzed by vitamin B12-dependent methionine synthase. This process not only helps regulate homocysteine levels—associated with cardiovascular risks—but also supports DNA synthesis and repair, amino acid metabolism, and neurotransmitter production.

Applications

Nutritional Supplementation: Used to prevent or treat folate deficiency, especially in populations with increased needs such as pregnant women.
Cardiovascular Health: Helps manage elevated homocysteine levels, which are linked to cardiovascular diseases.
Mental Health: Investigated for its potential benefits in treating major depressive disorder due to its role in neurotransmitter synthesis.
Hyperhomocysteinemia: Particularly beneficial for patients undergoing hemodialysis who often exhibit elevated homocysteine levels.

Routes of Administration

Levomefolate calcium is typically administered orally in the form of tablets or capsules. It can also be found in combination products with other vitamins and medications.

Safety and Side Effects

Levomefolate calcium is generally well tolerated; however, some side effects may occur:
Common Side Effects: Mild gastrointestinal disturbances such as nausea or abdominal discomfort.
Serious Side Effects: Rarely, it may cause allergic reactions characterized by rash, itching, swelling, or difficulty breathing. High doses can lead to symptoms associated with elevated vitamin D/calcium levels if combined with vitamin D supplements.

Pharmacokinetics

Absorption: Rapidly absorbed in the proximal small intestine through both active transport and passive diffusion. Peak plasma concentrations are generally reached within 0.5 to 1.5 hours after oral administration.
Distribution: Exhibits biphasic kinetics with a fast turnover pool (half-life of approximately 4 to 5 hours) and a slow turnover pool that can persist for over 100 days.
Protein Binding: Approximately 56% of levomefolate calcium binds to plasma proteins, facilitating its distribution throughout the body.
Metabolism: Converted into tetrahydrofolate (THF) via enzymatic action before being polyglutamylated, which enhances its efficacy in metabolic reactions.

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Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

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