Pharmaceutical Intermediate Retatrutide High Purity Retatrutide

Retatrutide (LY3437943) acetate is a revolutionary polypeptide drug on the echemi platform, which is a triple - agonist peptide for the glucagon receptor (GCGR), glucose - dependent otropic polypeptide receptor (GIPR), and glucagon - like peptide - 1 receptor (GLP - 1R).

Basic Information

• CAS Number: 2381089 - 83 - 2

• Molecular Formula: C221H342N46O68

• Molecular Weight: 4731.33

• Appearance: White powder

• Purity: ≥99.0% (HPLC)

• Storage Condition: Store at - 20°C in a dry and cool place.

Mechanism of Action

Retatrutide can simultaneously activate GLP - 1R, GIPR, and GCGR. Activating GLP - 1R can promote secretion, inhibit glucagon release, reduce blood sugar, and delay gastric emptying to reduce appetite. Activating GIPR can enhance the effect of secretion, further reduce blood sugar, and play a role in lipid metabolism. Activating GCGR can promote fat decomposition and energy metabolism, increasing basal metabolism, thus helping with weight loss.

Clinical Application

• Indications: Mainly used for the treatment of obesity and type 2 diabetes. For obesity, it is suitable for adults with a body mass index (BMI) of ≥30 kg/m² or ≥27 kg/m² with obesity - related complications such as hypertension and hyperlipidemia. For type 2 diabetes, it can be used as an adjuvant treatment for diet and exercise, especially for patients with poor blood sugar control or combined with obesity.

• Clinical Trial Results: In a phase Ⅱ clinical trial, the retatrutide 12 - mg treatment group achieved weight loss of ≥5%, ≥10%, and ≥15% in 100%, 93%, and 83% of the participants, respectively, with an average weight loss of 24.2%.

Usage and Precautions

• Administration Route: Subcutaneous , usually a long - acting preparation once a week. The sites can be the abdomen, thigh, or upper arm.

• Dose Adjustment: The initial dose is generally 2 mg, and then it is gradually increased according to the patient's tolerance and treatment response to reduce gastrointestinal side effects. The dose should be adjusted according to the doctor's advice.

• Contraindications: Contraindicated in patients with a history of medullary thyroid carcinoma and multiple endocrine neoplasia syndrome. Use with caution in patients with pancreatitis and renal insufficiency.

Characteristics and Advantages

• Multiple Mechanisms of Action: By activating three receptors at the same time, it can more comprehensively regulate blood sugar, control appetite, promote fat decomposition and energy metabolism, achieving better weight - loss and blood - sugar control effects.

• Significant Weight - Loss Effect: The clinical trial results show a significant weight - loss effect, which can reduce the weight by up to 24.2%, almost reaching the effect of weight - loss surgery.

• Long Half - Life: Its structure modification enables it to bind to albumin in the blood, prolonging its residence time in the blood. The half - life is about 14 days, so it only needs to be taken once a week, which improves patient compliance.

Our company is a modern advanced enterprise specializing in production and exportation of APIs, Pharmaceutical intermediates, plant extracts etc. Our products are widely used in medicine, health care products, cosmetics, nutritional supplements and food additives areas. Our factory covers an area of 95 acres, the proposed construction of the plant will be GMP standards, the factory environment clean and tidy, rational layout, with large and medium-sized production workshop and repocessed shop. It is equipped with advanced equipment quality inspection and research center. Those products of both quality and technical content have reached the domestic advanced level. Since its establishment, the company has attached great importance to the team training and technical reform. Our modern production equipment guarantees for a fast and effective production with a superior degree of accuracy throughout the whole production line, everything is done in-house, processing, extraction, packaging and transportation of all links, ensuring maximum quality and efficiency. We are constantly research and development new ingredients and innovative new products, have earned the respect & Admiration from the worldwide customers. After years of continuous development, company has been accumulated rich experience in international trade and customer resources, established a stable customer base and perfect marketing service network. In addition, the company has established long-term technical cooperation with experts and professors from many universities and research institutes in the province.