(R)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate 98%Min RC00040

Manufacturer: Hangzhou Royalchem Co.,LTD.

Website:  www.cnroyalchem.com

【 Providing a complete set of intermediates and impurities for LCZ696 】

【 Providing a complete set of intermediates and impurities for LCZ696 】

【 Providing a complete set of intermediates and impurities for LCZ696 】

1.  Basic Information

Chemical Name :
(R)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate

Synonyms :

LCZ696 Intermediate

N-[(1R)-2-[1,1'-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester

(R)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropane-2-yl)carbamate  

CAS Number : 1426129-50-1

Molecular Formula : C₂₀H₂₅NO₃

Molecular Weight : 327.42 g/mol

EINECS Number : 202-804-9  

2.  Physical & Chemical Properties

Appearance : Typically supplied as a solid.

Boiling Point : 514.5 ± 50.0 °C (Predicted)

Density : 1.103 ± 0.06 g/cm³ (Predicted)

pKa : 11.85 ± 0.46 (Predicted)

Storage Conditions : 2–8°C (recommended for stability)

InChI Key : TYQICOFAZDVKMK-GOSISDBHSA-N

3.  Applications & Significance

Primary Use : Critical intermediate in synthesizing  LCZ696  (sacubitril/valsartan), a dual-action drug for hypertension and heart failure.

Synthetic Route : Synthesized from  BOC-D-tyrosine methyl ester  via multi-step organic reactions  1 .

Role in Pharma :

Used in R&D and commercial production of angiotensin receptor-neprilysin inhibitors (ARNIs).

Listed as a reference standard (USP/EP/BP grade) for quality control 

4 .  Safety & Regulatory

Classification : Pharmaceutical intermediate; impurity reference standard.

Handling Precautions : Standard lab practices for organic compounds (use PPE, avoid inhalation).

Regulatory Compliance : Meets USP/EP/BP standards for analytical use .