N-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl] carbamate RC00173

Manufacturer: Hangzhou Royalchem Co.,LTD.

Website:  www.cnroyalchem.com

【  Providing a complete set of intermediates and impurities for  Tedizolid 】

【  Providing a complete set of intermediates and impurities for  Tedizolid 】

【  Providing a complete set of intermediates and impurities for  Tedizolid 】

Product Name:  N-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl] carbamate 

CAS Registry Number:  1220910-89-3 

Synonyms:

Carbamic acid, N-[3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-

3'-Fluoro-4'-(carbamoyloxy)-[1,1'-biphenyl]-3-carboxylic acid, 6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl analog (less common)

(Often referenced by its structure or internal research codes)

Molecular Formula:  C₁₄H₁₁FN₆O₂ 

Molecular Weight:  314.28 g/mol

Chemical Structure:  The molecule consists of:

A central biphenyl-like core:  A phenyl ring connected to a pyridine ring.

Fluoro substituent:  A fluorine atom at the 3-position (meta) of the phenyl ring.

Carbamate group (-OC(O)NH₂):  Attached to the oxygen at the 4-position (para relative to fluoro) of the phenyl ring. This is the  N-[...] carbamate  moiety.

Tetrazole substituent:  A 2-methyl-2H-tetrazol-5-yl group attached at the 6-position of the pyridine ring.

Appearance:  Typically supplied as a solid. Specific form (powder, crystalline) and color (white, off-white, beige, etc.) depend on the supplier and purity.  Purity:  Available in various purities, commonly ≥95%, ≥98%, or ≥99% (by HPLC or NMR). Specific purity should be confirmed with the supplier.  Melting Point:  Data specific to this compound may be limited. Expected to be >150°C (typical range for similar complex heterocyclic solids), but exact value requires experimental determination per batch.  Solubility:  Solubility characteristics depend on the solvent and exact crystalline form. Typically: * Low solubility in water. * Moderate to good solubility in polar organic solvents like dimethyl sulfoxide (DMSO), dimethylformamide (DMF), methanol, ethanol, acetonitrile. * Low solubility in non-polar solvents like hexane or diethyl ether.  Storage Conditions:  Store in a cool, dry place. Typically recommended at 2-8°C (refrigerated) or -20°C for long-term storage. Protect from light and moisture. Keep under inert atmosphere (e.g., nitrogen or argon) if highly sensitive.  Stability:  Generally stable under recommended storage conditions. May be sensitive to prolonged exposure to light, moisture, strong acids, strong bases, or oxidizing agents. Stability data should be confirmed with the supplier.

Category:  Organic Building Block; Pharmaceutical Intermediate; Chemical Research Compound.  Primary Application:

Research Chemical:  Primarily used in scientific research and development, particularly in medicinal chemistry and drug discovery.

Pharmaceutical Intermediate:  Serves as a key synthetic intermediate in the preparation of more complex target molecules, potentially for biologically active compounds or drug candidates. The presence of the carbamate, fluoro, pyridyl, and tetrazolyl groups makes it a versatile building block for creating molecules targeting specific receptors or enzymes.

Key Structural Features:

Carbamate Group (-OC(O)NH₂):  A functional group commonly found in drugs (e.g., prodrugs, enzyme inhibitors) and agrochemicals. It can act as a hydrogen bond donor/acceptor.

Fluorine Atom:  A common bioisostere that can influence lipophilicity, metabolic stability, and binding affinity.

2-Methyl-2H-tetrazol-5-yl Group:  A heterocyclic bioisostere often used as a replacement for carboxylic acids or other polar groups due to its similar acidity and hydrogen bonding capabilities. The 2-methyl group protects it from metabolism.

Pyridinyl-Phenyl Linkage:  Creates a biaryl system, a common structural motif in pharmaceuticals influencing conformation and target binding.

Safety Information (General - Specific SDS Required):

Hazard Statements:  Not fully characterized. Treat as potentially hazardous. May cause skin irritation, eye irritation, respiratory irritation, or toxicity if swallowed or absorbed through skin. Potential health hazards from chronic exposure are unknown.

Precautionary Statements:  Wear protective gloves, protective clothing, eye protection, and face protection. Handle only in a well-ventilated area, preferably a fume hood. Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid contact with skin and eyes. Wash skin thoroughly after handling. Do not eat, drink, or smoke when using. Use appropriate containment to avoid environmental release.

First Aid Measures:  IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Seek medical advice/attention immediately. Show safety data sheet to physician.

Disposal:  Dispose of contents/container in accordance with local, regional, national, and international regulations. Must not be disposed of with household waste.

Handling:  Handle with care using standard laboratory safety practices. Minimize dust generation and inhalation. Avoid contact. Use chemical-resistant gloves (e.g., nitrile). Ensure adequate ventilation.