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Pharmaceutical raw material Aprocitentan raw powder for hypertension treatment

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CAS No.:

1103522-45-7

Content:

99%

Port:

qingdao

Brand:

Packaging:

Aluminium foil bag,25kg drum

Sample Available:

Yes

Price valid (until):

2025-09-29

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NATURE INDUSTRIAL LIMITED

Company Type:

Trader

Location:

Hongkong, China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

7 days

Qualification:

Main Products:

Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332

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Product Description
Seller Information

Description

99% purity Aprocitentan New drugs for hypertension

Product Name: APROCITENTAN
Synonyms: N-Despropyl Macitentan;Aprocitentan;5-(4-BROMOPHENYL)-4-[2-(5-BROMOPYRIMIDIN-2-YL)OXYETHOXY]-6-(SULFAMOYLAMINO)PYRIMIDINE;N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]sulfamide;APROCITENTAN; ACT-132577; ACT 132577; ACT132577; DESPROPYL MACITENTAN;Despropyl Macitentan;Macitentan N-Despropyl Impurity
CAS: 1103522-45-7
MF: C16H14Br2N6O4S
MW: 546.19

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APROCITENTAN

Items	Specifications
color	White
purity	99%

APROCITENTAN function

Aprocitentan (ACT-132577) is a sulfonamide small molecule oral drug that can target endothelin receptors A/B (ETA/B) and

antagonize the binding of endothelin-1 to ETA/B. Aprocitentan is the first endothelin-1 receptor antagonist approved by the U.S.

Food and Drug Administration (FDA) for the treatment of refractory hypertension.

It has brought a new treatment method to patients with hypertension, especially those with refractory hypertension, and is of milestone significance.

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ECHEMI Editorial Reference

ACT-132577 is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting.
ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It derives from an ethylene glycol.|Aprocitentan is under investigation in clinical trial NCT03541174 (A Research Study to Show the Effect of Aprocitentan in the Treatment of Difficult to Control (Resistant) High Blood Pressure (Hypertension) and Find Out More About Its Safety).

Basic Info

Product Name:

ACT-132577

Other Name:

ACT-132577;N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]sulfamide;N-Despropyl Macitentan;Aprocitentan;Despropyl Macitentan

CAS No.:

1103522-45-7

Molecular Formula:

C16H14Br2N6O4S

InChIKeys:

DKULOVKANLVDEA-UHFFFAOYSA-N

Molecular Weight:

546.19316

Exact Mass:

543.91600

UNII:

MZI81HV01P

Categories:

Circulatory System Drugs

Characteristics

PSA:

150.59000

XLogP3:

4.38590

Density:

1.841±0.06 g/cm3(Predicted)

Boiling Point:

705.0±70.0 °C(Predicted)

See More ACT-132577 Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More ACT-132577 Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Weight Loss Peptide,Reta,Tirz,Sema,5 Amino 1mq,Cosmetic raw material,API,SLU-PP-332

Location:
Unit D01,3/F., Wong King Industrial Building,No.2 Tai Yau Street, Kowloon

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7 days

Total Annual Revenue:
$50 million-$100 million

Total Employees:
51-100

Year of Establishment:
2012

We have more than 10 years experience in the pharmacy filed. Mainly manufactures pharmaceutical APIs,Pharmaceutical intermediate and Cosmetic raw material. Owing to the good quality and competitive price, we have a very good reputation in China's pharmaceutical circles.

In the principle of "Quality Oriented", Jianfeng passed the certification of ISO9001:2008 Quality Management System.

Our products are based on bulk, high volume, wholesale price, third party testing, certificate reporting, and bring high quality ingredients to many domestic and overseas enterprises.

"Honesty, practicality, innovation, development" are our values. Jianfeng would like to cooperate with you with high quality products and competitive price.
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Pharmaceutical raw material Aprocitentan raw powder for hypertension treatment

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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